Ask about this productRelated genes to: NF200 antibody
- Gene:
- COP1 NIH gene
- Name:
- COP1 E3 ubiquitin ligase
- Previous symbol:
- RFWD2
- Synonyms:
- FLJ10416, RNF200
- Chromosome:
- 1q25.1-q25.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-13
- Date modifiied:
- 2019-01-21
Related products to: NF200 antibody
Related articles to: NF200 antibody
- Transcriptional dysregulation in cancer is accompanied by an anabolic transcriptional response driving proliferation and metabolic adaptation. We previously found that oncogenic ETS variant transcription factor 4 (ETV4) overexpression is associated with DNA replication, glycolytic metabolism, tumor progression, and poor prognosis in non-small cell lung cancer (NSCLC). ETV4 is markedly overexpressed in multiple NSCLC datasets, including TCGA-LUAD and TCGA-LUSC. Importantly, ETV4 expression positively correlates with ubiquitin-specific protease 7 (USP7) and mitogen-activated protein kinase 7 (MAPK7) levels. While the E3 ligase constitutive photomorphogenesis protein 1 (COP1) is known to regulate ETV4 ubiquitination and degradation, ETV4 deubiquitination remains unclear. Our study reveals that USP7 deubiquitinates ETV4 and protects it from K11- and K48-linked ubiquitination and proteasomal degradation in NSCLC cells. ETV4 transcriptionally controls the expression of the MAPK pathway key gene MAPK7, which encodes extracellular signal-regulated kinase 5 (ERK5), and participates in the regulation of cell proliferation. Genetic knockdown or pharmacological inhibition of USP7 affects the transcriptional activity of ETV4 on its target gene MAPK7/ERK5. USP7 inhibitor P22077 significantly attenuates ETV4-MAPK7-induced cell proliferation in vitro and tumor growth in vivo. Furthermore, elevated ETV4, USP7, and ERK5 protein expressions are associated with poor prognosis of NSCLC patients. These findings identify that USP7 regulates the deubiquitination, stability, and transcriptional activity of ETV4, contributing to the malignant phenotype of ETV4. Inhibition of USP7 might be a promising target in NSCLC with the dysregulation of ETV4 or hyperactivated MAPK signaling. - Source: PubMed
Publication date: 2026/05/06
Meng XueZhang JiaxiZhang NingHou YuqiLi YimengKang JiaLi RuxinShi YinghuiWang JuanCheng LixinXing Lingxiao - - Source: PubMed
Publication date: 2026/04/17
Luo DakuiWang KangjunjieYang YufeiLi QingguoLi Xinxiang - Ultraviolet-B (UV-B) radiation, a biologically active component of sunlight, profoundly influences plant physiology, growth, and metabolism. In this review, we integrate current understanding of how plants perceive and adapt to UV-B stress through multilayered regulatory networks. At the physiological level, UV-B exposure elicits dose-dependent effects ranging from enhanced photoprotection and secondary metabolite accumulation at low doses to oxidative damage and growth inhibition under high-intensity conditions. Central to UV-B perception is the photoreceptor UVR8, which activates signaling cascades involving COP1, HY5, and MYB transcription factors to regulate gene expression and promote photomorphogenesis and flavonoid biosynthesis. Concurrently, plants utilize UVR8-independent pathways, such as MAPK and PIKK cascades, to mitigate DNA damage and activate stress responses. Epigenetic modifications, particularly DNA methylation and histone acetylation, further modulate UV-B-responsive gene expression and contribute to stress memory and transgenerational adaptation. We also elucidate the transcriptional networks and non-coding RNAs involved in secondary metabolite biosynthesis, particularly those enhancing flavonoid production. Finally, we discuss emerging applications of UV-B signaling in crop improvement and outline future directions including multi-omics integration, epigenetic inheritance mechanisms, and real-time UV-B monitoring technologies. Together, these insights reveal the intricate mechanisms by which plants adapt to UV-B radiation and provide a basis for leveraging UV-B responses in agriculture and plant biotechnology. - Source: PubMed
Publication date: 2026/04/20
Lu ZhaogengBao HongyanRen ShixiongJin Biao - Wild trees have a long prematuration period before flowering. Threshold tree size and light conditions are suspected to trigger the reproductive maturation, though genetic evidence is needed to confirm this. We investigated the genetic mechanisms underlying the onset of reproduction using two wild maple species, Acer amoenum var. amoenum (Aa) and A. mono var. glabrum (Am). - Source: PubMed
Publication date: 2026/04/24
Suzuki MakiFujioka YukineHisamoto Yoko - Light is the primary energy source for photosynthesis and an important signal regulating seedling growth, hormonal balance, and metabolic adaptation. In this study, seedlings of were grown under six light quality treatments, including white light (WL), blue light (BL), red light (RL), far-red light (FrL), and mixed RL: FrL ratios at 1:1 (1:1L) and 1:2 (1:2L). All treatments were applied at a constant photosynthetic photon flux density of 400 μmol·m·s. The results showed that BL, FrL, and 1:2L significantly promoted stem elongation, whereas RL and 1:1L increased root collar diameter. Hormone assays revealed a clear antagonistic pattern between gibberellic acid (GA) and abscisic acid (ABA), with GA contents elevated under BL and FrL but reduced under RL, while ABA showed the opposite trend. Transcriptomic analysis showed that different light spectra regulated the expression of photoreceptors (PHYB, CRY1 and CRY2) and downstream factors (COP1, PIF3, HY5). BL stimulated flavonoid biosynthesis, RL enhanced phenylpropanoid and cell wall related pathways, and FrL induced carotenoid and stilbenoid metabolism. There results indicated that light spectra regulate seedling growth by integrating photoreceptor signaling, hormone dynamics, and secondary metabolism. The study improves our understanding of light responses in gymnosperms and provides a physiological and molecular basis for optimizing nursery light management and afforestation practices. - Source: PubMed
Publication date: 2026/04/07
Liu BoWang ZhengningSong YushuangLiu QingqingWang Lixin