Ask about this productRelated genes to: BMP5 Blocking Peptide
- Gene:
- BMP5 NIH gene
- Name:
- bone morphogenetic protein 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6p12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-06-05
- Date modifiied:
- 2015-08-24
Related products to: BMP5 Blocking Peptide
Related articles to: BMP5 Blocking Peptide
- Protein kinases are essential regulators of cellular signaling pathways and are deeply involved in breast cancer (BC) progression. This study aimed to identify BC molecular subtypes and construct a prognostic model based on kinase-related genes (KRGs). - Source: PubMed
Publication date: 2026/05/12
Ye ShuanglaiJi Shengwei - Human pluripotent stem cells (hPSCs)-derived cardiomyocytes have tremendous advantages in generating cell models that are suitable for the study of cardiovascular diseases and their treatment. However, there is a lack of systematic screening and analysis of important genes for inducing hPSCs differentiation into cardiomyocytes. - Source: PubMed
Publication date: 2026/04/24
Zhang HongTu SimeiXu ChangWu RuoshiWu JiayiHuang XinLuo XiaoqinLuo XiaoweiQu Xinjian - Red and/or processed meat are established colorectal cancer (CRC) risk factors. Genome-wide association studies (GWAS) have reported over 200 variants associated with CRC risk. We used functional annotation data to identify subsets of variants within known pathways to construct pathway-based Polygenic Risk Scores (pPRS) to assess interactions with meat intake. - Source: PubMed
Publication date: 2026/04/01
Sanchez Mendez JoelQueme BryanFu YuboMorrison John LLewinger Juan PabloKawaguchi Eric SMi HuaiyuObón-Santacana MireiaMoratalla-Navarro FerranMartín VicenteMoreno VictorQu ConghuiHuyghe Jeroen RNewcomb Polly APhipps Amanda IThomas Claire EConti David VWang JunPlatz Elizabeth AVisvanathan KalaKeku Temitope ONewton Christina CUm Caroline YKundaje AnshulGunter Marc JDimou NikiPapadimitriou Nikosvan Duijnhoven Fränzel J BMännistö SatuRennert GadWolk AlicjaHoffmeister MichaelBrenner HermannTian YuLe Marchand LoïcBouras EmmanouilTsilidis Konstantinos KBishop D TimothyMaclnnis Robert JBuchanan Daniel DUlrich Cornelia MPeoples Anita RPellatt AndrewLi LiDevall Matthew AAlbanes DemetriusBerndt Sonja IGruber Stephen BRuiz-Narvaez EdwardSong MingyangDrew David AChan Andrew TGiannakis MariosHsu LiPeters UlrikeStern Mariana CGauderman W James - Tendon adhesion following injury remains a major clinical challenge, primarily driven by excessive fibrosis and aberrant cellular differentiation. Here, we identify fibroblast-derived bone morphogenetic protein 5 (BMP5) as a key paracrine signal that promotes mesenchymal stromal cell (MSC) differentiation into myofibroblasts, thereby exacerbating adhesion formation. Mechanistically, we show that paclitaxel (PTX) suppresses BMP5 expression in fibroblasts via inhibition of the HIF-1α pathway, thus blocking MSC-to-myofibroblast transition. To achieve sustained local delivery, we developed polylactic acid based membranes (PLA) incorporating PTX in either a blended (PLB) or conjugated (PLC) form, with PLC demonstrating controlled release, reduced cytotoxicity, and superior anti-adhesion efficacy. Collectively, our results reveal a BMP5-centered fibroblast-MSC axis as a key driver of tendon adhesion and establish PTX-loaded PLC membranes as a mechanism-based therapeutic strategy. - Source: PubMed
Publication date: 2026/03/04
Wang KaiLi YanhaoYang YuanhaoZhang PeilinLu YifanZhao JunjieZhang XinshuPang SaHu JiachengYin WeiguangGuo YongyuanWu JingleiLiu Shen - The dental papilla (DP) is essential for the development of dentin and pulp. The extensive cellular heterogeneity within the DP is a critical factor underlying the complex and precise formation of dental structures during odontogenesis. However, the critical cell types within human DP that play essential role in tooth development and regeneration remain largely uncharacterized. In this study, we analyzed the heterogeneity of human DP cells using single-cell sequencing and identified Gliomedin (GLDN) DP stem cells (DPSCs) were a group of progenitors at an early stage of tooth development and play a key role in the development of pulp and dentin. GLDN DPSCs strategically accumulate in human DP tissue near the interface of the newly formed dentin or pulp. Functional assays demonstrated that GLDN DPSCs exhibited enhanced self-renewal, migratory capacity, and odontogenic differentiation potential in vitro compared to GLDN DPSCs. Moreover, GLDN DPSCs effectively induce the migration and tube formation of endothelial cells, which are essential for tooth development. The ectopic dental pulp regeneration model confirmed that GLDN DPSCs can regenerate a vascularized dental pulp structure with an odontoblast layer in vivo. Given their functional capabilities, this population of cells has been designated as GLDN odontogenic stem cells (OSCs). Mechanistically, GLDN is essential for maintaining the phenotype and function of GLDN OSCs through BMP5 signaling via autocrine and paracrine mechanisms. In conclusion, this study identifies a previously uncharacterized essential subpopulation of OSCs essential for dental pulp development and regeneration. - Source: PubMed
Publication date: 2026/02/28
Liao ChengchengLiu JinglunLi MaojiaoYang BingqianYu YejiaYang JianSu XiaoxiaMa ShixingLi HanchaoZhang JingyiTian WeidongLiao Li