Ask about this productRelated genes to: KiSS1 Blocking Peptide
- Gene:
- KISS1 NIH gene
- Name:
- KiSS-1 metastasis suppressor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-05-18
- Date modifiied:
- 2018-01-05
Related products to: KiSS1 Blocking Peptide
Related articles to: KiSS1 Blocking Peptide
- Maternal protein restriction during lactation affects the metabolic and reproductive development of offspring by modulating the hypothalamic-pituitary-testicular (HPT) axis. - Source: PubMed
Publication date: 2026/04/29
Rodrigues Willian do Nascimento de SouzaRomano Renata MarinoGrassiolli SabrinaOliveira Jeane MariaMoreira Veridiana MotaFlauzino Marianna Wirthmann PompeoPeres Maria Natália ChimirriRomano Marco AurélioMathias Paulo Cezar de Freitas - The brain and testes are connected via the hypothalamic-pituitary-gonadal (HPG) axis. Both are vulnerable to radiofrequency electromagnetic radiation (RF-EMR). However, no comprehensive study had evaluated the effects of RF-EMR on key hormones along this axis. Hereby, this study evaluated the effect of RF-EMR on the hormonal changes along the axis, including the neuropeptide kisspeptin. A total of 18 (N = 18) adult Sprague-Dawley rats were divided into three groups (n = 6): Control, 4 h, and 24 h. The Control group was sham-exposed to an inactive router. The exposed groups were subjected to 2.45 GHz RF-EMR for 4 and 24 h daily, for 60 days at a 20 cm distance. The power density was 0.141 W/m with a whole-body specific absorption rate (SAR) of 0.41 W/kg. No significant changes were observed in hypothalamic gene expression or serum kisspeptin levels. GnRH levels increased significantly in both exposed groups, while FSH and LH remained unchanged. Testicular testosterone was significantly reduced in the 24 h group, while serum testosterone was elevated in the 24 h group compared to the 4 h group. In conclusion, prolonged 2.45 GHz RF-EMR exposure caused selective changes in components of the HPG axis, particularly involving GnRH and testosterone, suggesting potential endocrine effects on male reproductive regulation. - Source: PubMed
Publication date: 2026/05/20
Vijay SivasatyanIbrahim Siti FatimahOsman KhairulZulkefli Aini FarzanaMat Ros Mohd FarisyamJamaludin NorazurashimaTaha Syed Muhamad Asyraf SyedHairulazam AtikahJaffar Farah Hanan Fathihah - Zearalenone (ZEA) is a potent estrogenic mycotoxin known to disrupt reproductive functions, but its precise central neuroendocrine mechanisms remain unclear. This study investigated the effects of ZEA on the hypothalamic-pituitary Kiss1/GPR54 signaling pathway in weaned gilts. A total of 32 gilts were randomly assigned to four dietary treatments contained with 0, 0.15, 1.5, or 3.0 mg/kg ZEA for a 32-day feeding trial. Histopathology, immunohistochemistry, and mRNA/protein expression analyses of GPR30, Kiss1, GPR54, GnRH, and GnRHR in the hypothalamus and pituitary gland were conducted. ZEA exposure induced significant histological damage in both tissues. In the hypothalamus, Kiss1, GPR54, GnRH, and GnRHR exhibited a non-linear response, increasing at moderate doses and decreasing at 3.0 mg/kg ZEA, whereas GPR30 expression was continuously upregulated. In the pituitary gland, GnRHR showed a similar non-linear pattern. Furthermore, high-dose ZEA down-regulated pituitary Kiss1 and GPR54 while up-regulating GnRH and GPR30 expressions. In conclusion, ZEA induces reproductive neuroendocrine toxicity through a complex, dose-dependent modulation of the Kiss1/GPR54 signaling axis. The persistent upregulation of GPR30 suggests it acts as a crucial mediator in disrupting this endocrine feedback loop within the hypothalamus and pituitary gland. - Source: PubMed
Publication date: 2026/04/22
Yuan ZixueZhou MinLuan YueKong LeiYang WeirenJiang Shuzhen - The signaling pathways that control embryonic development and migration of gonadotropin-releasing hormone (GnRH) neurons, as well as the postnatal fate and function of differentiated cells, are the subject of ongoing research. Here, we examined the role of phosphoinositides in this complex multistep process by generating GnRH neuron-specific phosphatidylinositol 4-kinase alpha knockout mice. The knockout mice were indistinguishable from their control littermates at all time points studied. However, adult knockout females and males were infertile, as reflected by the absence of GnRH immunoreactivity and expression, and reduced expression of pituitary gonadotroph-specific genes, accompanied by underdeveloped gonads and reproductive organs. Kisspeptin immunoreactivity was preserved and expression was modified in a nucleus-specific-manner, consistent with the loss of circulating sex steroid hormones. Embryonic neurogenesis and migration of GnRH neurons were not dramatically impaired, as evidenced by normal expression in the hypothalamus of neonatal animals and the presence of immunoreactive GnRH neurons in infantile mice in comparable distribution to age-matched controls. However, their cellular degeneration was observed in infantile mice, accompanied by reduced expression. GnRH neuron-specific expression of tdTomato confirmed their postnatal degeneration, leading to their death, while ectopic tdTomato-positive cells located in the lateral septum remained unaffected. These findings indicate that phosphatidylinositol 4-kinase alpha activity is not critical for the establishment of the GnRH neuronal system, in contrast to the survival of GnRH neurons. - Source: PubMed
Publication date: 2026/05/05
Constantin StephanieNessa NaseratunStojilkovic Stanko S - Dysregulation of the HPG axis in PCOS causes increased frequency and amplitude of gonadotropin-releasing hormone (GnRH) pulsatility in the hypothalamus. Single nucleotide polymorphisms (SNPs) in the KISS1 gene may be associated with altered neuroendocrine signaling in PCOS. The present study aims to evaluate the association between two polymorphisms (rs4889 and rs5780218), their haplotypes, and the odds of PCOS in Indonesian women. - Source: PubMed
Publication date: 2026/02/02
Pratama GitaR Febri RirinMaidarti MilaWiweko BudiAsmarinah S Widyahening IndahAndraini TrinovitaBayuaji HartantoHestiantoro AndonPangestu Mulyoto