Ask about this productRelated genes to: Wnt1 Blocking Peptide
- Gene:
- WNT1 NIH gene
- Name:
- Wnt family member 1
- Previous symbol:
- INT1
- Synonyms:
- -
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-03-18
Related products to: Wnt1 Blocking Peptide
Related articles to: Wnt1 Blocking Peptide
- Increased global lifespan is paralleled by a rise in non-communicable diseases with osteoarthritis and dementia, including Alzheimer's disease, impacting all nations with severe disability, death, and financial burden. - Source: PubMed
Publication date: 2026/05/07
Maiese Kenneth - The use of Exosomes (EXOs) to induce the regeneration of hair follicles has received much attention today. The present study was conducted to survey the effects of Citrus limon-derived EXOs (EXO-CLs) on promoting hair growth. EXOs were isolated from citrus limon by the filtration technique. According to NanoSight DynamicLight Scattering and Scanning Electron Microscopy, the extracted EXOs had a size of 147 nm and a spherical morphology. The flow cytometry analysis showed the expression of surface markers CD9 (64.6%), CD63(66.2%), and CD81(65.2%). The MTT test showed a significant increase in the percentage of human skin fibroblast cell viability in the group treated with EXO-CLs (400 µg/mL) compared to the control. The evaluations performed in vivo phase showed a significant increase in the thickness of dermis, the number of hair follicles, and the percentage of collagen were observed in the group treated with EXO compared to the negative control group. The expression ratio of Wnt-1, β-Catenin, Lef1, Vegf, Tgf-β1, and Collagen I genes respectively, increased by a factor of 4.4, 4.8, 2.7, 2.3, 4.6, and 2.4 in EXO-CLs groups compared to the negative control group. According to the findings, the EXO-CLs could promote hair follicle regeneration in vivo and improve hair regrowth. - Source: PubMed
Publication date: 2026/05/06
Raoufimanesh FatemehAtyabi Seyed MohammadMohamadali MarjanMirshaby Zeinab AlsadatIrani ShivaDinarvand Rassoul - Stanford type A thoracic aortic aneurysm and dissection (TAAD) affects the ascending aorta and aortic arch and can cause sudden death due to rupture. Epidemiological studies have shown that TAAD occurs more frequently in men than women. Vascular smooth muscle cells (VSMCs) are one of the major cell types in the vascular wall and play a critical role in the pathogenesis of TAAD. Recent studies have highlighted the developmental heterogeneity of VSMCs in the ascending aorta and aortic arch, which are derived primarily from the second heart field (SHF) and cardiac neural crest (CNC), respectively. However, whether sex influences the biological properties of these lineage-specific VSMCs and thereby contributes to TAAD susceptibility remains poorly understood. In this study, we generated Wnt1-Cre/Rosa26-mTmG lineage-tracing reporter mice and performed single-nucleus RNA sequencing using the ascending aortae and aortic arch from both sexes. Our results showed that male VSMCs exhibited higher expression of genes associated with maintenance of contractility, whereas female VSMCs preferentially expressed genes involved in extracellular matrix (ECM) organization. Together, these data suggest that the ascending aorta and aortic arch in females may exhibit greater mechanical resilience, which partially account for the lower incidence of TAAD in women. - Source: PubMed
Publication date: 2026/04/30
Wang YanzhiLuo ChengWang SongmaoLi LiFu KailongLyu Qing Rex - Patients referred with an osteogenesis imperfecta (OI) phenotype exhibit marked genetic heterogeneity, and a substantial proportion may harbor variants associated with early-onset osteoporosis (EOO) or OI-mimicking disorders rather than classical collagenopathies. This study aimed to define the genetic spectrum and non-COL1A1/2 variant burden in a cohort clinically diagnosed with OI. - Source: PubMed
Publication date: 2026/04/30
Ozturk Fatma NihalKeskin Ece - Postmenopausal osteoporosis (PMOP) is characterized by high-turnover bone loss and oxidative stress. Astragaloside IV (AS-IV) exhibits antioxidant and immunomodulatory activities, yet its skeletal effects and mechanistic basis in ovariectomized (OVX) models remain incompletely defined. - Source: PubMed
Publication date: 2026/04/13
Li Ya-QingYao Xian-YingJing YanLiu Zi-YiWang Xing-WangLiang MingJiang Shuai-YuLu TaoChen ChenGao Yan-Ping