Ask about this productRelated genes to: Wnt1 Blocking Peptide
- Gene:
- WNT1 NIH gene
- Name:
- Wnt family member 1
- Previous symbol:
- INT1
- Synonyms:
- -
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-03-18
Related products to: Wnt1 Blocking Peptide
Related articles to: Wnt1 Blocking Peptide
- To elucidate the genetic etiology of osteogenesis imperfecta (OI) in affected families and to characterize reproductive decision-making, reproductive interventions, and pregnancy outcomes of these families. - Source: PubMed
Publication date: 2026/09/05
Yuan ShiminHu XiaoYi DuoZhao XiaomengWan ZhenxingHe Wen-BinHu LiangLu GuangxiuLin GeTan Yue-QiuDu Juan - The early developmental stages of fish exhibit the highest mortality and greatest environmental sensitivity throughout their life cycle. This period encompasses a series of crucial biological events, including morphogenesis, organ differentiation, and nutritional mode transition from fertilized eggs to newly hatched larvae. Although largemouth bass (Micropterus nigricans) is a commercially important fish species in China, the molecular regulatory mechanisms governing its endogenous nutritional stage remain largely unexplored. To elucidate the molecular basis of this critical period, we performed transcriptomic profiling across six consecutive developmental stages (Multicellular, Blastula, Gastrula, Neurula, Organogenesis, and 5 day post hatching larvae). Our results reveal stage-specific transcriptional programs: the multicellular-to-blastula transition is characterized by stage-specific enrichment of by cell cycle and DNA replication pathways, with MCM complex (mcm2-5) upregulation accelerating proliferation; the blastula-to-gastrula transition features activation of bmp4, fgfr2, and lft1 for germ layer induction; the neurula stage exhibits transcriptional bursts and enrichment of neural tube-related pathways; organogenesis involves simultaneous activation of focal adhesion (col1a1b, col4a5, tnc) and Wnt signaling (wnt1, wnt4, wnt3a) pathway; and 5 dph larvae show visual function maturation, with light transduction genes (gnat1, gnat2, gucy2f, pde6b) identified as hub genes. Mfuzz analysis further reveals sustained upregulation of Cluster 14 (igf2r、napin、vamp7、il1b、aco2) indicating functional maturation, while Cluster 29 (mcm10, espl1, cep152, cep44, cep295) confirms declining cell division activity. Collectively, this study provides a transcriptomic resource for understanding largemouth bass embryonic development and offers molecular insights for improving hatchery practices. - Source: PubMed
Publication date: 2026/08/31
Hua JixiangTao YifanSun HuiZhu TaideWang XiaoyiHuang XiaochenWang WenLu SiqiLu JianQiang Jun - Uterine leiomyomas (ULMs) are the most common benign gynecological tumors affecting women in reproductive age. Symptoms such as abnormal uterine bleeding, pelvic pain, and infertility may occur, leading to a significant decline in patients' quality of life. In addition, ULMs represent the second leading indication for gynecological surgery in Brazil, imposing a substantial economic burden on the public healthcare system. However, despite their high prevalence and clinical impact, there is still no curative clinical treatment for these tumors, and the molecular mechanisms underlying their development and clinical behavior remain poorly understood. Recent studies have demonstrated the involvement of the Sonic Hedgehog (SHH) signaling pathway in uterine mesenchymal tumors. Therefore, the aim of this study was to investigate the expression profile and regulation of the SHH and Wnt signaling pathways in ULMs, as well as to evaluate their potential role in tumor progression through integrative analyses of promoter methylation, mRNA expression, and microRNA-mediated regulation. Initially, 106 genes related to SHH, Wnt signaling pathways were examined in ULM, compared to normal myometrium (MM) by real-time PCR. Interactions among SHH pathway genes were assessed through multivariate analysis. In addition, methylation profiles of nine key SHH-related genes were evaluated using methylation-specific assays, and the expression of 84 microRNAs (miRNAs) was analyzed in association with differentially expressed genes potentially involved in tumorigenesis. Differential expression analysis identified 23 dysregulated genes, including 13 upregulated and 10 downregulated genes. Multivariate analysis suggested that SHH pathway activation in ULMs occurs independently of SHH-PTCH1 binding and may involve GLI1, CCND1, and BCL-2. Significant DNA methylation alterations were detected in PTCH1, SMO, GLI1, GLI3, GREM1, and WNT1. Furthermore, 16 miRNAs were differentially expressed, eight of which showed significant correlations with their predicted target genes. Collectively, these findings suggest that ULM pathogenesis involves a complex regulatory network integrating SHH and Wnt signaling pathways, epigenetic modifications, and microRNA-mediated post-transcriptional regulation. These results provide novel insights into the molecular mechanisms underlying ULM development and identify candidate regulatory elements that may serve as potential biomarkers or therapeutic targets in future functional studies on uterine fibroids. - Source: PubMed
Publication date: 2026/08/29
Purcino Grazielle Marques DuarteFerreira Kelly PedrozoBozzini NiloBaracat Edmund ChadaCarvalho Katia Candido - Adolescent Idiopathic Scoliosis (AIS) is a spinal deformity of unknown etiology that begins in the intervertebral disc and emerges during pubertal growth. In the vertebral growth plate, adjacent to the disc, powerful growth plate morphogens (GPMs) modulate this growth. We evaluated whether GPMs can also alter the capacity of annulus fibrosus (AF) disc cells to proliferate and/or remodel their extracellular matrix (ECM). - Source: PubMed
Publication date: 2026/08/22
Stradovnik-Poikilidis KTeunissen MRiemers F Mvan Doeselaar MFoolen JAbinzano FTryfonidou M ACallens S J PIto K - Animal body color patterns are highly diverse and play critical roles in camouflage, intraspecific communication, and environmental adaptation. Holothuria edulis, an important echinoderm inhabiting tropical waters, exhibits a typical dorsoventral dichromatism. This unique body color difference represents a key phenotypic trait for its habitat adaptation; however, the core differential genes regulating this trait remain to be elucidated. In this study, comparative transcriptome sequencing was performed on the dorsal and ventral body wall tissues of H. edulis, leading to the identification of a number of differentially expressed genes (DEGs), followed by GO functional annotation and KEGG pathway enrichment analysis. GO enrichment analysis indicated that the DEGs were significantly enriched in functional categories such as extracellular region, peptidase inhibitor activity, and tetrapyrrole binding. KEGG pathway analysis further revealed significant enrichment of protein digestion and absorption, the TNF signaling pathway, and cholesterol metabolism. Notably, the pigmentation-related gene FMO2 was highly expressed in the dorsal body wall tissue, whereas cyp1a1, ZIC1, Slc7a11, WNT-1, and ADAMTS20 were highly expressed in the ventral body wall tissue. This study identified DEGs and enriched pathways associated with dorsoventral body color differences in H. edulis, providing new insights into the molecular regulatory mechanisms underlying body color pattern formation. From the perspective of aquaculture applications, body color is one of the important traits affecting the quality and market value of sea cucumber products. Elucidating the molecular mechanisms of body color variation can provide a scientific basis for molecular marker-assisted breeding of superior sea cucumber variety. - Source: PubMed
Publication date: 2026/08/14
Yan JunqiLiu ShilinZhang LibinSu FangWu QianwenTolon Mustafa TolgaGökçek Emel ÖzcanXing Lili