Ask about this productRelated genes to: MMP3 Blocking Peptide
- Gene:
- MMP3 NIH gene
- Name:
- matrix metallopeptidase 3
- Previous symbol:
- STMY1, STMY
- Synonyms:
- -
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: MMP3 Blocking Peptide
Related articles to: MMP3 Blocking Peptide
- Human breast milk (HBM) is an ideal nutritional source for the growth and development of infants. In addition, HBM contains hormones, growth factors, microRNAs and exosomes that perform various physiological functions. This study investigates the immunomodulatory effects of HBM-derived exosomes on myeloid cells and chondrocytes, and implications for juvenile idiopathic arthritis. HBM-derived exosomes were isolated and characterized using nanoparticle track analyzer and Western blotting. The HBM-derived exosomes treatment decreased the expression of inflammatory mediators and proinflammatory cytokines in mouse peritoneal macrophages upon lipopolysaccharide stimulation. Flow cytometry analysis of bone marrow-derived macrophages indicated that exosomes promoted M2 polarization, as evidenced by a decrease in cells expressing CD80 (M1 marker) and a concurrent increase in cells expressing M2 marker CD206. In addition, exosome treatment attenuated the mitogen-activated protein kinase signaling pathway by reducing the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, and IκB-α, thereby reducing the expression of inducible nitric oxide synthase, cyclooxygenase-2, metalloprotease (MMP)-1, MMP-3, and MMP-13 in SW1353 chondrocytes following IL-1β stimulation. These findings suggest that HBM-derived exosomes promote macrophage polarization toward an anti-inflammatory M2 phenotype and exert significant immunomodulatory effects. - Source: PubMed
Publication date: 2026/04/30
Kwon DahyeonYoo Ji YoonDan Kang-BinKim Ki-UkLee Ji-YunMin Hyeyoung - Kruppel-like factor 15 (KLF15) is a transcription factor that promotes anabolic pathways and suppresses catabolic signalling in joint tissues. KLF15 regulates adipocyte differentiation through peroxisome proliferator-activated receptor-γ (PPARγ), which suppresses inflammation via the nuclear factor-κB pathway. This study aimed to clarify the effects of KLF15 in a mouse model of collagen antibody-induced arthritis (CAIA). - Source: PubMed
Publication date: 2026/04/28
Anjiki KHayashi SKikuchi KTakashima YIkuta KWada KTachibana SOnoi YSuda YSaito AMaeda TKamenaga TTsubosaka MKuroda YNakano NMatsumoto THosooka TOgawa WKuroda R - A key biopharmaceutic barrier in systemic treatment of pulmonary infections is achieving sufficient drug exposure at infected lung sites with cationic antimicrobial peptides (AMPs), which are prone to proteolytic degradation, rapid clearance, and off-target interactions in circulation. S-thanatin (Ts) is a cationic AMP with potent in vitro antibacterial activity and low resistance liability, yet its unfavorable in vivo fate limits therapeutic efficacy. To address this limitation, we implemented a spatiotemporally controlled systemic delivery strategy that couples pathogen-associated localization with enzyme-activated, on-site release. As a practical formulation to realize this concept, Ts@CPN@PM was electrostatically assembled with bacteria-pre-stimulated macrophage membranes for pathogen-associated targeting and equipped with a matrix metalloproteinase-3 (MMP-3)-cleavable NFF-3 switch for infection-microenvironment-triggered release. Ts@CPN@PM achieved ∼95 % in vitro Ts release under elevated MMP-3 conditions and preferentially accumulated in infected lungs (>70 % by fluorescence quantification). In an antibiotic-resistant E. coli pneumonia model, Ts@CPN@PM improved survival (10 % to 60 %), reduced pulmonary bacterial burden (∼2 log CFU/g), and attenuated inflammatory responses. Ts@CPN@PM showed favorable cytocompatibility and hemocompatibility in vitro, and systemic biosafety was confirmed in healthy mice. Overall, these findings support spatiotemporal control of lung-site exposure as a feasible route to improve the in vivo fate and therapeutic index of cationic AMPs for pulmonary bacterial infections. - Source: PubMed
Publication date: 2026/04/25
Tao WeiyanLi MingzhenZhou YunlinLiu KexinWu GuoqiuGuo JingruDi Bin - Diabetic kidney disease (DKD) is significantly impacting both quality of life and survival rates. The Shen-Yan-Fang-Shuai (SYFS) formula is a traditional Chinese medicine (TCM) compound widely used in the clinical treatment of DKD with proven efficacy, though its potential mechanism of action remains unclear. This study attempts to elucidate the therapeutic efficacy, mechanisms of action, and active compounds of the SYFS formula in the treatment of DKD. - Source: PubMed
Kang YiJin QianZhou MengqiZheng HuijuanLi DanwenWang XuezheZhou JingweiLv JieWang Yaoxian - Postmenopausal females are at increased risk of intervertebral disc (IVD) degeneration due to estrogen decline. While both estrogen supplementation and low-magnitude high-frequency vibration (LMHFV) are proposed as therapies for osteoporosis, their effects and potential interactions on IVD degeneration remain unclear. Therefore, the aim of this work was to investigate the individual and combined effects of 17β-oestradiol (E2) and LMHFV in a papain (PP)-induced ex vivo model of IVD degeneration. - Source: PubMed
Publication date: 2026/04/22
Jansen Jan UlrichFigel FelizitasWidmayer FranziskaVogt MortenAhrens MariaWilke Hans-JoachimIgnatius AnitaHaffner-Luntzer MelanieNeidlinger-Wilke CorneliaTeixeira Graciosa Quelhas