Ask about this productRelated genes to: SOD1 Blocking Peptide
- Gene:
- SOD1 NIH gene
- Name:
- superoxide dismutase 1
- Previous symbol:
- ALS, ALS1
- Synonyms:
- IPOA
- Chromosome:
- 21q22.11
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: SOD1 Blocking Peptide
Related articles to: SOD1 Blocking Peptide
- Stress-induced hair depigmentation is closely associated with neurogenic oxidative stress and dysfunction of melanocyte stem cells. Activation of antioxidant defense pathways, particularly the Nrf2-ARE pathway, may protect melanocytes from oxidative damage. - Source: PubMed
Cui JingboDuan LinxiaQu HuiNing JingLi ZhiZhang Huihua - This study evaluates the antioxidant activity of a topical water-in-oil cream formulated with saffron (Crocus sativus) and grape seed (Vitis vinifera) extracts and characterizes its physicochemical properties. HPLC profiling confirmed that grape seed extract was rich in catechins (26.7%), epicatechins (21.9%), and procyanidins B1 and B2 (13.6% and 9.5%), while saffron extract contained high levels of trans-4-GG-crocin (28.4%), trans-2-gg-crocin (23.5%), and picrocrocin (13.4%). In vitro assays using human lymphocyte cultures demonstrated that saffron extract (2.5%) reduced fast-flash chemiluminescence from 36.1 × 104 to 14.3 × 104, while grape seed extract (5.0%) decreased the same parameter to 16.3 × 104. Light-sum ROS output similarly declined by 39%-50% across extract concentrations. Gene expression analysis revealed significant upregulation of SOD1, NFE2L2, and JUN, indicating activation of endogenous antioxidant pathways. The final cream formulation, containing 2.5% saffron and 5.0% grape seed extract, exhibited a stable pH of 5.9, viscosity of 31,869 cP, and spreadability of 24.32 g/cm/s, with no observed irritancy during application tests. These results demonstrate that combining crocin-rich saffron and proanthocyanidin-rich grape seed extracts have a synergistic antioxidant effect and can be successfully incorporated into a stable, skin-compatible topical preparation. The formulation shows promise as a dermal antioxidant therapy aimed at reducing oxidative stress and supporting skin rejuvenation. - Source: PubMed
Zam WissamAlkhaddour AzizHousheh Samer - Susceptibility to decompression sickness (DCS) shows wide interindividual variability, the origins of which remain poorly understood. To better elucidate its mechanisms, we previously developed a rat strain with more than threefold higher resistance to DCS through selective breeding. In this study, we examined baseline expression of genes related to antioxidant defense and mitochondrial biogenesis in the lungs and liver of DCS-resistant and non-resistant Wistar rats. None of the animals were exposed to hyperbaric conditions, allowing us to focus on constitutive expression differences potentially underlying genetic resistance to DCS. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was performed, and data were analyzed using two-way ANOVA to assess the effects of selection, sex, and their interaction. In the lungs, no significant selection effect was observed for genes involved in mitochondrial biogenesis () or antioxidant defense ( and ). In contrast, in the liver, expression of both gene groups was significantly decreased in resistant rats (p < 0.0083, Bonferroni correction), except for . These lower hepatic expression levels align with the previously reported reduction in citrate synthase activity and lower basal oxygen consumption in the soleus muscle of resistant rats. Together, these findings suggest that hepatic metabolism and mitochondrial function may play key roles in DCS susceptibility, potentially through reduced mitochondrial activity and lower reactive oxygen species (ROS) production in resistant animals. - Source: PubMed
Publication date: 2026/04/23
Dugrenot EmmanuelOrsat JérémyGouin EmmanuelGuerrero FrançoisGuernec Anthony - To determine age- and sex-related differences in antioxidant genes and oxidative stress in the mouse cornea. - Source: PubMed
Publication date: 2026/04/20
Martis Renita MDowlath SasheenIsmail SalimGhani Fayvan der Werf BertSherwin TrevorLim Julie C - Bisphenol A (BPA) exposure disrupts the maternal-fetal environment, resulting in fetal growth restriction and tissue damage. While taurine is recognized for its protective effects and its role in regulating tauro-conjugated bile acid (TCBA) metabolism, its specific mechanism of action underlying BPA exposure remains unclear. This study systematically investigated whether taurine alleviates BPA-induced placental dysfunction, oxidative stress, and fetal weight restriction at gestation day (GD) 18.5 by regulating TCBA metabolism using a murine pregnancy model. Our results showed that gestational BPA exposure significantly inhibits the Nrf2-Keap1 signaling pathway, triggering a vicious cycle of oxidative stress and inflammation. This cascade disrupted placental nutrient transport, impaired hepatic detoxification, and perturbed the gut microbiota-bile acid (BA) axis, ultimately leading to fetal weight restriction at GD18.5. Taurine supplementation exerted multi-level protective effects by activating the Nrf2-Keap1 pathway, upregulating the expression of antioxidant enzyme genes (, , ), inhibiting pro-inflammatory factors (, ), and simultaneously mitigated oxidative stress and inflammatory damage in the placenta and liver; restoring the expression of nutrient transport genes such as syncytin B () and insulin-like growth factor 2 () to repair placental function and ensure fetal nutrient supply, while upregulating cytochrome P450 family 27 subfamily A member 1 () expression to maintain hepatic BA synthesis homeostasis; and remodeling the gut microbial community structure by restoring the abundance of beneficial bacteria (Muribaculaceae, ), inhibiting the abnormal proliferation of , and improving BA metabolic imbalance, thereby normalizing the "liver-gut microbiota-BA" metabolic axis. Our findings indicate that taurine mitigates BPA-induced maternal-fetal toxicity by targeting the microbiota-BA-oxidative stress axis. This study highlights taurine as a promising nutritional intervention strategy for protecting pregnancy against environmental toxicant exposure. - Source: PubMed
Publication date: 2026/04/22
Xu LeiYin ChenggangFan YuyangYang JiaqiMing DongxuLi YanpinSun WenjuanLi XilongPi Yu