Ask about this productRelated genes to: PDK1 Blocking Peptide
- Gene:
- PDK1 NIH gene
- Name:
- pyruvate dehydrogenase kinase 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-14
- Date modifiied:
- 2016-01-06
- Gene:
- PDPK1 NIH gene
- Name:
- 3-phosphoinositide dependent protein kinase 1
- Previous symbol:
- -
- Synonyms:
- PDK1
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-23
- Date modifiied:
- 2015-08-25
Related products to: PDK1 Blocking Peptide
Related articles to: PDK1 Blocking Peptide
- Despite being a well-established oncogenic regulator of metabolism promoting aerobic glycolysis, the pan-cancer prognostic value of PDK1, along with its immunomodulatory activity, is still poorly understood. In this research, an integrated multi-omics analysis was used to describe the expression of PDK1 and its prognostic role and immunomodulatory activity in different types of cancers, but specifically in kidney renal clear cell carcinoma (KIRC). It was found that PDK1 was overexpressed in various types of cancers, in which it always presented poor prognostic factors. Low PDK1 levels of tumors preserved an immunologically active microenvironment, and high PDK1 expression was recognized to be sensitive to chemotherapy and targeted agents. In KIRC, in particular, high PDK1 levels were linked to high TIL and PD-L1, which supports the idea that PDK1 is a combined immunological and prognostic biomarker. These results define the multifactorial functions of PDK1 in tumorigenesis and immunoregulation, which opens the path to the creation of PDK1-targeted therapies in clinical oncology. - Source: PubMed
Publication date: 2026/02/28
Duan ShuangshuangZhang MengmengSun MiaoAbudusaimaiti GulinaizaierZhang LijunLiu Huibin - LCZ696 (sacubitril/valsartan) can attenuate early cardiac remodelling of heart failure (HF), although it is less effective in severe remodelling. Surgical ventricular reconstruction (SVR) is used to treat refractory HF with large ventricular aneurysms (LVA), but residual remodelling limits the long-term survival. It is unknown whether LCZ696 can mitigate residual remodelling. - Source: PubMed
Publication date: 2026/01/12
Yan JunyuLi DantongQiu XuetingTan NingYang Dahao - Metabolomics analyses suggest abnormal purine metabolism during the development of osteoporosis. This study aimed to investigate the role of purine metabolism-related genes in osteoporosis. - Source: PubMed
Publication date: 2025/11/07
Zeng YuqingHu JintaoLu JianweiZhu Yunyun - Deubiquitinating enzymes are important regulators of cancer progression. We explored the role and regulatory mechanisms of the deubiquitinating enzyme ubiquitin-specific protease 22 (USP22) in neuroblastoma (NB). USP22 expression was upregulated in NB patient tissue samples and its expression correlated with their overall survival. Knockdown of USP22 in NB cell lines suppressed cell proliferation, invasion and glycolysis, and enhanced apoptosis. A coimmunoprecipitation assay identified a relationship between USP22 and 3-phosphoinositide-dependent protein kinase 1 (PDK1). USP22 stabilized PDK1 expression via deubiquitination; PDK1 overexpression reversed the effects of USP22 knockdown on the malignant behaviors of NB cells. Dual-luciferase reporter assay and RNA immunoprecipitation were utilized to clarify the relationship between Yin Yang-1 (YY1) and USP22. Yin Yang-1 regulated PDK1 expression via promoting USP22 transcription. USP22 knockdown in a xenograft assay also inhibited tumor growth via regulating PDK1. Taken together, these results indicate that USP22 regulated by YY1 plays a promotional role in NB progression by mediating the deubiquitination of PDK1. - Source: PubMed
Zhang DiGu TingCao GengfeiHu ChunweiYang Huiting - Macrophage M2 polarization plays a critical role in the progression of endometriosis (EMS), and glycolysis has emerged as a potential therapeutic target. This study aimed to investigate the interplay between glycolytic signaling and macrophage M2 polarization in EMS. - Source: PubMed
Publication date: 2025/06/04
Li HanChai Xiaoshan