Ask about this productRelated genes to: ICAM1 Blocking Peptide
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 Blocking Peptide
Related articles to: ICAM1 Blocking Peptide
- Cigarette smoking is a leading cause of cardiopulmonary disease through chronic inflammation, but individual studies on its effects on cardio-inflammatory biomarkers have yielded inconsistent results. This meta-analysis synthesizes evidences of smoking on cardio-inflammatory biomarkers. - Source: PubMed
Publication date: 2026/08/06
Hassanpour HosseinNasiri LeilaMojtahed MarziehKarimi-Shayan TaherehVaez-Mahdavi Mohammad-Reza - Autologous T cells engineered to express a HER2 chimeric antigen receptor (CAR) have shown limited clinical efficacy. To broaden antitumor activity, we co-expressed a chimeric costimulatory receptor (CCR) targeting ICAM1 (ICCR) in HER2 CAR T cells. ICAM1 is upregulated by inflammatory cytokines, reinforces immune-synapse formation, and is elevated in aggressive or dedifferentiated tumors, including those with heterogeneous or low HER2 expression. HER2 CAR/ICCR T cells preserved potent cytotoxicity against HER2-high targets and showed significantly enhanced killing of HER2-low cell lines compared with HER2 CAR T cells alone. ICCR augmented NF-κB activation particularly under low HER2 conditions. Upon repeated stimulation with HER2-negative tumor cells, HER2 CAR/ICCR T cells underwent nearly 10-fold expansion with superior cytotoxicity, whereas HER2 CAR T cells failed to expand. , both constructs rapidly eliminated HER2-high tumors, but only HER2 CAR/ICCR T cells achieved complete clearance of HER2-low tumors, with delayed kinetics consistent with clonally expanded, tumor-specific T cells. TCR sequencing confirmed substantially greater clonal expansion in HER2 CAR/ICCR T cells across and studies. This dual-receptor platform (HMJ01) has supported IND authorization for a first-in-human trial in patients with HER2-positive and HER2-low gastric cancer. - Source: PubMed
Publication date: 2026/07/24
Vedvyas YogindraYang YanpingMitra AroshiKim Yoo-ShinFredette Nate Rde Azevedo RicardoKota Daniel JMin Irene MJin Moonsoo M - Systemic sclerosis (SSc) is driven by persistent inflammation and microvascular damage. Statins are hypothesized to offer vasculoprotective effects beyond lipid-lowering. We systematically evaluated the efficacy and safety of statins in SSc across biochemical, vascular, and patient-centred outcomes. - Source: PubMed
Publication date: 2026/08/14
Khalifa Mostafa AAlghzawi Hamzah MAnan Shehabeldin SAl Rifai AhmadAnwar Ayah AAl-Saedi Hayder Ali RaheemAwady EmanMasood IslamBadr Mohamed ElsayedIsmail MohamedMuayaid ObadaAhmed Omar MBdarnh OsamaAlkhatib SarahElnagar FaresHegazi YasserJebril Mohammad - Oxidative stress is central to keratoconus (KC) pathogenesis, and NRF2 is a key antioxidant regulator. However, an model linking NRF2 loss to KC has been lacking. We generated CRISPR/Cas9 -knockout (KO) mice and assessed 4-month-old corneas by slit-lamp fluorescein staining, optical coherence tomography (OCT), histology/immunofluorescence and transmission electron microscopy (TEM), reactive oxygen species (ROS) assays, βIII-tubulin whole-mounts, and whole-cornea single-cell RNA-seq with Seurat/CellChat. loss caused central corneal thinning, increased fluorescein uptake, and disrupted epithelial tight junctions; the stroma exhibited reduced keratocyte density, disorganized collagen, and depleted proteoglycans. ROS accumulated while antioxidant effectors (Hmox1, Aldh3a1) declined; inflammatory/fibrotic markers (ICAM1, iNOS, α-SMA) and immune infiltration increased, mirroring clinical KC. The subbasal nerve plexus was markedly reduced and disorganized. Single-cell profiling revealed loss of extracellular matrix (ECM) -maintenance programs in keratocytes, epithelial-to-mesenchymal transition (EMT)-like epithelial changes, reduced limbal stemness, endothelial dysfunction, immune polarization, and remodeled intercellular signaling (attenuated FN1/OCLN; augmented APP/CALCR). Importantly, pharmacological activation of NRF2 with the activator RTA-408 in complementary rescue experiments partially reversed oxidative stress and inflammation. These data support a feed-forward axis in which NRF2 deficiency drives oxidative stress, inflammation, and extracellular-matrix degradation that extends to corneal innervation, while NRF2 supplementation partially mitigates these pathological changes. The mouse exhibits several pathological features similar to those observed in human keratoconus and provides a platform to investigate disease mechanisms and evaluate NRF2-targeted interventions. - Source: PubMed
Publication date: 2026/08/10
Li XiaoxueGu JianingSun XihaoLiang YuqinMao ShengruChen YuexiWang XiDing ChengchengChen JiansuCui Zekai - L., known in Arab countries as molokhia, is a leafy plant rich in many carotenoids, minerals, and vitamins; its seeds are also reported to offer cardioprotective effects. Although the cardioprotective effects of molokhia are ascribed to the presence of cardiac glycoside compounds, the exact action mechanisms remain uninvestigated. - Source: PubMed
Publication date: 2026/07/30
Abd El-Mordy Fatma MohamedMaher Sherif ATammam Omar YElrehany Mahmoud AHisham MohamedRofaeil Remon RRateb Mostafa EOraby Hesham FIbrahim Mahmoud A AShawky Ahmed MBringmann GerhardAbdelmohsen Usama RamadanShady Nourhan Hisham