Ask about this productRelated genes to: CCR3 Blocking Peptide
- Gene:
- CCR3 NIH gene
- Name:
- C-C motif chemokine receptor 3
- Previous symbol:
- CMKBR3
- Synonyms:
- CC-CKR-3, CKR3, CD193
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-30
- Date modifiied:
- 2016-10-05
Related products to: CCR3 Blocking Peptide
Related articles to: CCR3 Blocking Peptide
- Heat stress (HS) affects female reproductive efficiency by disrupting redox homeostasis and activating inflammatory responses in the corpus luteum (CL), a metabolically active tissue essential for pregnancy maintenance. This study reveals the protective effect of resveratrol against HS-induced luteal injury in pregnant mice through the regulation of oxidative stress and cytokine-chemokine-mediated inflammatory and immune responses. The pregnant mice were divided into three groups: control, HS, and resveratrol +HS. Heat stress was applied at 40 ± 0.5 °C for 7 days, with resveratrol (10 mg/kg) given orally 2 h before exposure to HS. The results showed that heat exposure reduced serum total superoxide dismutase activity and increased malondialdehyde level, causing significant disruption of luteal morphology with cellular disorder and vacuolization, which was partially overcome by resveratrol pretreatment. Transcriptomic profiling showed that HS induced a strong immunological and inflammatory response, involving cytokine-cytokine receptor interaction and chemokine signaling. Resveratrol significantly attenuated HS-induced transcriptional changes. The RT-qPCR results showed that HS increased chemokine ligands (, , ) and cytokine receptors , , ), which were suppressed by resveratrol. The chemokine-based inflammatory module is one of the most important regulatory properties of the HS response, according to the network analysis. Stable binding of resveratrol with major chemokine receptors was supported by molecular docking and molecular dynamics simulations. Collectively, HS induces oxidative, structural, and inflammatory alterations in luteal tissue, while resveratrol attenuates these changes by being associated with improved antioxidant status and suppression of cytokine-chemokine-mediated responses. - Source: PubMed
Publication date: 2026/04/14
Tariq MuhammadQuddus AbdulVictor Kossinga Koulet André SaintBeshah Kebede HabtegiorgisYan YexiaoMao Dagan - Monocyte-derived macrophages (MoMFs) play key roles in liver inflammation and fibrogenesis, with their heterogeneity affecting metabolic dysfunction-associated steatotic liver disease (MASLD) progression. However, current therapeutic strategies targeting macrophage-mediated inflammation have shown limited clinical efficacy in MASLD. - Source: PubMed
Publication date: 2026/04/24
Xu HaozheYang LuFang PeiyangSun JieZhong XinjieDeng WanqingLi SiqiZhou LongyangFan JinguoZhang DongSun Guangyong - [This corrects the article DOI: 10.1002/ccr3.72364.]. - Source: PubMed
Publication date: 2026/04/23
- Schizophrenia (SCZ) is frequently accompanied by peripheral immune dysregulation, yet robust and reproducible blood-based molecular markers remain limited. - Source: PubMed
Wu JieNiu RuizeLiu ZijunLi YuanyuanZhang YunqiaoTeng ZhaoweiZeng YongBao Tianhao - Thunderstorm-related asthma (TA) is a distinct environmental health emergency marked by abrupt surges in asthma exacerbations following thunderstorm events. Although peripheral eosinophilia has been implicated as a risk factor, the phenotypic and functional characteristics of eosinophils contributing to TA remain insufficiently defined. This study aimed to delineate the phenotypic characteristics of circulating eosinophil subsets in pediatric patients experiencing thunderstorm-related asthma exacerbations. - Source: PubMed
Miao QingHou XiaoLingXiang LiZhang TaiYuanLiu Chen