Ask about this productRelated genes to: FAF1 Blocking Peptide
- Gene:
- FAF1 NIH gene
- Name:
- Fas associated factor 1
- Previous symbol:
- -
- Synonyms:
- CGI-03, hFAF1, HFAF1s, UBXD12, UBXN3A
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-10
- Date modifiied:
- 2016-01-21
Related products to: FAF1 Blocking Peptide
Related articles to: FAF1 Blocking Peptide
- Metastasis is the leading cause of death in clear cell renal cell carcinoma (ccRCC) patients. Anoikis, a form of programmed cell death induced by the loss of cell-extracellular matrix interactions, is a critical factor in hindering metastasis. Nevertheless, the regulatory mechanisms underlying anoikis resistance in ccRCC remain poorly characterized and warrant further investigation. - Source: PubMed
Publication date: 2026/05/01
Wei HaotianLi ShenglongZhu ShimiaoXu ChenglongWang YueLi ZhaochenGuan YujingLi JiahangJiang RunzeGe XianglianYi TailongXu XingXie YangTian JingPiao YingzheZhang PingQuan ChangyiJin Xun - DNA methylation (DNAm) is implicated in age-related disease susceptibility. Some studies have reported alterations in DNAm patterns with sleep deprivation, yet this has not been demonstrated in long-term studies. We aimed to analyze whether prolonged mild sleep restriction (SR) results in differentially methylated loci (DML) in selected candidate circadian genes and explore changes in DML epigenome-wide. We conducted a pooled analysis of two randomized crossover trials of SR. Healthy adults (n=60; 65% women, age ≥20y) habitually sleeping 7-9h/night completed two 6-wk (week) intervention periods (condition): maintenance of habitual adequate sleep (AS, ≥7h/night) and SR (-1.5h/night), separated by a washout interval. We determined DNAm levels in morning fasting blood samples collected at baseline and endpoint using EPICv.2 array and multivariable adjusted models for repeated measures and analyzed the sleep condition x week interaction. Pathways and biological processes from the most significant DML were explored. In the candidate core circadian gene approach, sleep condition x week interactions were at cg02394126 (ARNTL; p˂0.001), cg23506964 (CLOCK; p=0.001), cg03701037 and cg06606972 (NPAS2; both p=0.009). In the exploratory EWAS, suggestive top DML were cg23738833 (SNHG3-RCC1; p=1.34E-06), cg13280380 (FAF1; p=2.25E-05), and cg03179866 (MMP12; p=2.78E-05). All but one (cg23738833) showed hypermethylation after SR vs AS. The most significant pathways associated with SR were aging-related genes involved in TGF-beta signaling, glucagon signaling, and fatty acid degradation. These findings reveal that prolonged mild SR is associated with DNAm in core clock candidate genes and suggests DML in other genes across the epigenome suggesting a potentially plastic epigenetic mechanism. Studies are needed to replicate these preliminary findings. - Source: PubMed
Publication date: 2026/03/21
Barragán RocioDye Christian KAggarwal BrookeJelic SanjaColtell OscarCorella DoloresSt-Onge Marie-Pierre - A single nucleotide polymorphism (SNP) on bovine chromosome 15 has been shown previously to be highly associated with resistance to disease caused by Theileria parva. The SNP comprises a CT mutation in a paralogue of the FAF1 gene. Disease caused by T. parva is of major economic importance in eastern to southern Africa and better control methods are urgently required. Genotyping cattle for this SNP will aid epidemiological studies to understand the origins and dissemination of resistance to T. parva and will facilitate marker-assisted breeding for resistant cattle. The current study reports the development of a simple and economic genotyping assay based on real-time, Fluorescence Resonance Energy Transfer (FRET)-based PCR. The assay was optimized to ensure reliable, automatic calling of the three genotypes and was validated by comparing the assay results to sequencing analyses on different sample types including extracted DNA, whole blood without extracting DNA and serum. The assay was used to genotype East African Shorthorn Zebu (EASZ) cattle from an intensively studied calf cohort from western Kenya. The results confirmed the protective effect associated with the T allele, and showed that it had no deleterious effect on the growth rate of this calf population. The assay was also used to determine variation in the frequency of the T allele in Boran cattle populations from different regions of eastern Africa. The assay will make a useful breeding selection tool especially in studies involving prevalence and evolution of the protective haplotype in different cattle populations. - Source: PubMed
Publication date: 2026/01/24
Miyunga Antoinette AluochKarani Benedict EboyaNjeru ReginaNangekhe GertrudeCook Elizabeth Anne JessieBronsvoort Barend Mark de ClareWragg DavidPrendergast JamesToye Philip - The AAA-ATPase VCP/p97 with its adapter Ufd1-Npl4 unfolds ubiquitylated substrate proteins to prepare degradation in the proteasome; however, the function of critical accessory factors remains unclear. Here, we show in the mammalian system that efficient protein degradation in the proteasome requires accessory adapters that boost p97-mediated unfolding likely by positioning Ufd1 for substrate loading. In a reaction that reconstitutes p97-Ufd1-Npl4-mediated unfolding coupled to proteasomal degradation, degradation was inefficient but stimulated by accessory adapters FAF1, FAF2, or UBXN7. Stimulation of proteasomal degradation was largely caused by an increase of p97 unfolding rates, conveyed by a helix-UBX segment in FAF1/2 that tethered the UT3 ubiquitin binding module of Ufd1 to the p97 N-domain. Mutations that abrogated the helix-Ufd1 interaction reduced stimulation of degradation, suggesting that accessory adapters position Ufd1 within the p97 complex to organize proficient substrate loading. Our results define the function of accessory adapters in mammals and highlight the complexity of substrate loading onto p97 for efficient substrate processing. - Source: PubMed
Publication date: 2026/03/06
Kracht MatthiasKröning Alexandervan den Boom JohannesGahlot PinkiKoska SandraKiss LeoMeyer Hemmo - Enhancer RNAs (eRNAs) are best known for their role in transcriptional regulation, where they facilitate enhancer-promoter communication and chromatin remodeling. Yet growing evidence suggests that their function may extend beyond the nucleus. Here, we systematically characterize the decay kinetics of eRNAs across human cell types using time-resolved transcriptomics and kinetic modeling. While most eRNAs undergo canonical exponential decay, a subset displays nonlinear dynamics, suggesting context-dependent degradation mechanisms. Perturbation of core decay regulators, including components of the mA and pathways, reveals that eRNA stability is modulated by a patchwork of pathways governing mRNA turnover. Integrating transcriptome-wide ribosome profiling, RNA-seq, and half-life data, we identify eRNAs associated with changes in mRNA stability and translation efficiency of their target protein-coding transcripts. Functional validation of one such eRNA, , shows that it regulates and mRNA independently of transcription and impacts cell migration. These findings redefine the regulatory scope of eRNAs, positioning them as active participants in post-transcriptional gene control and cellular behavior. The resulting decay profiles and regulatory annotations have been incorporated into the eRNAkit database, available at https://github.com/AneneLab/eRNAkit, enhancing its capacity for integrative systems-level analysis of eRNA function. - Source: PubMed
Publication date: 2026/04/16
Kuklinkova ReneBenova NataliaAnene Chinedu A