Ask about this productRelated genes to: PARD3 Blocking Peptide
- Gene:
- PARD3 NIH gene
- Name:
- par-3 family cell polarity regulator
- Previous symbol:
- -
- Synonyms:
- PAR3, PARD3A, Bazooka, Baz, ASIP, PPP1R118
- Chromosome:
- 10p11.22-p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-27
- Date modifiied:
- 2018-02-13
Related products to: PARD3 Blocking Peptide
Related articles to: PARD3 Blocking Peptide
- - Source: PubMed
Publication date: 2026/05/04
Vohra MehakKumar SimranSohnen PeriKaur SatinderSwamynathan SudhaHirose TomonoriKozmik ZbynekSwamynathan Shivalingappa K - Indigenous poultry genetic resources are crucial for breeding and food security. In Xinjiang, China, the Ili gamecock and Yemili chicken represent two indigenous breeds with distinct and valuable traits. The Ili gamecock is prized for its large body size and aggressive behavior, whereas the Yemili chicken shows remarkable adaptation to the cold environment of the Tacheng area, with strong disease resistance, and foraging ability suited to free-range grazing. As understanding their genetic basis is key to their conservation and sustainable use, we conducted whole-genome sequencing of 22 individuals from both breeds and integrated the data with 83 publicly available genomes to construct a comprehensive dataset of 12 global chicken populations. After identifying over 11.3 million high-quality SNPs, we assessed genetic diversity and population structure. Analyses revealed that the Ili gamecock is closely related to the Turpan gamecock, forming a distinct cluster. Selection signature analyses based on fixation index (FST) and nucleotide diversity ratio (π ratio) identified genomic regions under positive selection associated with aggressiveness and muscularity in gamecocks (e.g., NELL1, SOX5, SEMA3A, KCNMA1) and with stress response, intestinal integrity, and energy homeostasis in Yemili chickens (e.g.,MAPK8IP3, HBEGF, PARD3, ATP6V1B2, ATP5PD). This study provides a comprehensive genomic landscape of these two emerging Xinjiang breeds, elucidates their unique evolutionary histories, and offers valuable genetic resources for future conservation and breeding programs. - Source: PubMed
Publication date: 2026/03/21
Yang HaichenLiang QianqianSu PengAndersson GöranBongcam-Rudloff ErikRouzi MahabaJiang LinHan JilongYang Min - Single-cell RNA profiling has already been applied to normal airway samples, but no data set includes brushings collected from patients with allergic rhinitis combined with asthma (ARcoAS) at distinct and well-identified microanatomical regions in the airways. - Source: PubMed
Publication date: 2026/03/24
Xiao ZhenhaoZhang HaoshanLi ShashaPeng YangZheng RuiZhou ZiqingYe FanQiu HuijunWang XinyueYang QintaiZhang Yana - To classify differentially methylated CpG sites in periodontitis based on methylation shift direction and location relative to CpG islands. - Source: PubMed
Yoshida KokiSivaramakrishnan GowriAsa'ad Farah - Mouse female primordial germ cells (PGCs) undergo five synchronous, incomplete mitotic divisions and send each resulting germline cyst into meiosis to fragment and produce 4-6 oocytes and 24-26 supportive nurse cells. However, no system of polarity has been found to specify mammalian oocytes, link them appropriately to nurse cells and enable them to acquire high-quality organelles and cytoplasm. We report that mouse cysts develop an asymmetric Golgi, endoplasmic reticulum (ER), and microtubule-associated 'fusome,' similar to the oocyte-determining fusome in cysts. The mouse fusome distributes asymmetrically among cyst cells and enriches in future oocytes with Pard3 and Golgi-endosomal UPR (unfolded protein response) proteins. Spindle remnants rich in stable acetylated microtubules, like those building the and Xenopus fusomes, transiently link early mouse cyst cells for part of each cell cycle. A non-random gap in these microtubules predicts that initial cysts fragment into similar six-cell derivatives, providing a potential mechanism for producing uniform oocytes. Together with previous studies, these results argue that a polarized fusome underlies the development of female gametes from the PGC to follicular oocyte stages in diverse animals including mammals. - Source: PubMed
Publication date: 2026/03/11
Pathak MadhulikaSpradling Allan C