Ask about this productRelated genes to: Hsp90 antibody
- Gene:
- HSP90AA1 NIH gene
- Name:
- heat shock protein 90 alpha family class A member 1
- Previous symbol:
- HSPC1, HSPCA
- Synonyms:
- Hsp89, Hsp90, FLJ31884, HSP90N
- Chromosome:
- 14q32.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-27
- Date modifiied:
- 2016-10-11
Related products to: Hsp90 antibody
Related articles to: Hsp90 antibody
- Breast cancer (BC) ranks among the predominant malignancies in females globally. Growing research indicates that circular RNAs (circRNAs) exert important regulatory functions in multiple cancers. Nevertheless, the biological functions and underlying molecular mechanisms of numerous circRNAs in BC remain largely unelucidated. - Source: PubMed
Publication date: 2026/05/18
Cai MiaomiaoLu TaoLv ShanmeiZheng ZhuanGao LuWang HuiyingDong Xuejun - A close causal relationship exists between Alzheimer's disease (AD) and inflammation, where chronic inflammation serves as a critical driver in AD pathogenesis. To address this, a series of novel chalcone derivatives containing benzoyl-piperazin (2a-2v) were synthesized based on the multi-target drug synthesis strategy. All compounds were tested for their cholinesterase inhibitory activity and antioxidant activity, some compounds were further evaluated for their Aβ aggregation inhibitory ability, cytotoxicity, metal ion chelating ability, anti-inflammatory activity and in vivo mouse organ toxicity. On this basis, ADMET, molecular docking, network pharmacology analyses and molecular dynamics (MD) simulations were performed on the compounds with better activity. Among these, compound 2q emerged as the most promising candidate, exhibiting the strongest inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and anti- inflammatory effects. The IC values were 73.65 ± 3.50 μM, 88.20 ± 9.56 μM and 31.42 ± 1.91 μM, respectively. Notably, compound 2q achieved a 35.30 ± 2.40% inhibition rate against Aβ aggregation. Importantly, 2q demonstrated no significant cytotoxicity within the 200 μM concentration range, with no adverse effects on hepatic or renal function, though it exhibited certain metal-ion chelating capabilities. Network pharmacology analysis further identified its interaction with inflammation and AD associated gene targets, including HSP90AA1 and GSK-3β. Furthermore, the stability of the binding of 2q to AChE and BChE was verified by MD simulations. Collectively, these findings suggest that compound 2q, as a multi-targeting agent, warrants further investigation for its therapeutic potential in AD. - Source: PubMed
Publication date: 2026/05/15
He Zhi-XinLin Zhi-QiLiu Yuan-XiuWang Si-HongLin LinGuan Li-Ping - Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. Ubiquitin-specific proteases (USPs) modulate tumor progression by regulating substrate protein stability. However, the mechanisms of most DUBs in HCC remain poorly understood. This study aimed to investigate the role of USP9X in promoting HCC cell proliferation, survival, migration, and invasion. - Source: PubMed
Publication date: 2026/05/12
Jiang HanlinHuang LiningChen JiahaoJiang ZongyingNiu WeiqiaoWu JianwuQiao ZhimingPan YujiaJiang Xinwei - AKT1 is classically known as a serine/threonine kinase controlling cell survival and proliferation, yet its kinase-independent functions remain poorly understood. Here we show that recognition of dsRNA viral capsids by membrane-associated HSP90AA1 disrupts the HSP90-AKT1 interaction, inducing AKT1 dephosphorylation at Thr308. This non-phosphorylated AKT1 acts as a scaffold to recruit PDPK1 and SQSTM1, enabling PDPK1-dependent phosphorylation of SQSTM1 at Ser349 and selective loading of viral capsids into LC3C-positive phagophores for degradation. An IBDV capsid mutant defective in SQSTM1 binding escapes this pathway. In vivo, expression of non-phosphorylatable AKT1 suppresses rotavirus replication in a SQSTM1-dependent manner. These findings identify an HSP90-initiated, kinase-independent AKT1 signaling axis that licenses antiviral macroautophagy/autophagy. - Source: PubMed
Publication date: 2026/05/18
Hu ZeyuanLin LuluZhong YalanLi ChunyanLi YahuiWu HaichongZhou JiyongHu Boli - As a severe microvascular complication of diabetes, diabetic nephropathy (DN) lacks safe and effective preventive interventional strategies. Previous enterostomy-based colonic perfusion studies have shown that colon-targeted DHA delivery has superior hypoglycemic efficacy to intragastric or intrajejunal administration, though its invasiveness limits clinical translation. Notably, the naturally occurring esterified form of DHA and astaxanthin (DHA-acylated astaxanthin ester, DHA-AST) has been reported to exhibit intrinsic colon-targeted delivery properties. Here we report that oral DHA-AST exerts a significant renoprotective effect against DN in a preventive intervention model of KKAy mice, with superior efficacy to an equimolar DHA in combination with AST (DHA + AST). Specifically, relative to the DHA + AST group, DHA-AST gavage achieved selective colonic DHA enrichment, more effectively ameliorated systemic glucose dyshomeostasis, renal dysfunction, and histopathological damage, and suppressed renal inflammation, oxidative stress and fibrosis. These renoprotective effects were observed alongside improvements in systemic glucose homeostasis. Integrated multi-omics analyses revealed that DHA-AST remodeled gut microbiota composition and associated metabolic profiles, increased colonic trehalose production, and promoted the accumulation of trehalose in the kidneys. Oral trehalose supplementation partially phenocopied the renoprotective effects of DHA-AST against DN in KKAy mice. Combined network pharmacology and molecular docking assays identified HSP90AA1 as a putative molecular target of trehalose. Functional validation using TGF-β1-challenged glomerular mesangial cells showed that recombinant HSP90AA1 protein reversed the inhibitory effect of trehalose on profibrotic gene expression, whereas HSP90AA1 knockdown enhanced this effect. These findings demonstrate that DHA-AST ameliorates DN in association with a putative colon-kidney axis involving trehalose and HSP90AA1, providing preclinical evidence for the development of DHA-AST and trehalose as nutritional intervention candidates for DN. - Source: PubMed
Publication date: 2026/05/18
Yin JialinDeng XuHu YanqiZheng FangMeng HualiHuang XiaoliWang KeboZhao XiaodongSun LeiWu Hao