Ask about this productRelated genes to: TIMP1 protein
- Gene:
- TIMP1 NIH gene
- Name:
- TIMP metallopeptidase inhibitor 1
- Previous symbol:
- TIMP, CLGI
- Synonyms:
- EPO
- Chromosome:
- Xp11.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-26
Related products to: TIMP1 protein
Related articles to: TIMP1 protein
- UV radiation (UVR), a known skin-stressor causing inflammation, aging and carcinogenesis, activates the arylhydrocarbon receptor (AhR) and downstream molecules which are crucially involved in photo-induced skin damage. In this study, the potent UV protector melatonin was investigated regarding UVR-mediated activation of AhR and downstream molecules including tumor suppressor p27, DNA double-strand break marker pH2AX, cyclooxygenase-2 (COX-2), mitogen-activated protein kinase-14 (MAPK14)/p38α, matrix metalloproteinase-2 (MMP2) and tissue inhibitor of matrix metalloproteinase-1 (TIMP1). They were studied in ex vivo human full-thickness skin irradiated with UVA/B light (0, 300 mJ/cm) 0 h and 24 h post UV exposure, comparing skin pre-incubated with or without melatonin. Protein expression was analysed by immunofluorescence staining, gene expression by real-time qPCR. UV exposure significantly up-regulated AhR (p < 0.0001), p27 (p < 0.001) and pH2AX (p < 0.0001) protein expression 0 h and 24 h post-irradiation which was significantly counteracted by melatonin (10 M) at both time points. Further, melatonin significantly reduced gene expression of AhR by 21.2% (p < 0.01), p27 by 24.8% (p < 0.01), COX-2 by 42.9% (p < 0.001), MAPK14 by 6.6% (p < 0.05) and MMP2 by 8.2% (p < 0.05), and caused a 10.2% (n.s.) TIMP1 reduction tendency 24 h post-irradiation. Thus, melatonin prevented UV-dependent expression of AhR and downstream regulators of AhR-mediated processes possibly related to inflammation, cellular aging and carcinogenesis on protein and gene level in UV-irradiated skin. - Source: PubMed
Pustelnik KatharinaBurner TeresaHoetzenecker WolframFischer Tobias W - Mass spectrometry (MS)-based proteomics approaches have proven to be a powerful tool to discover clinical biomarkers for dental caries diagnosis and management. Saliva, acquired enamel pellicle (AEP), and dentin are three common sample medium. However, MS-based proteomics of dental caries is currently facing two major problems: (1) the analytical coverage of the dental caries proteome is relatively limited (<3000 proteins), which may hamper our understanding of the function of the key but low-abundance proteins. (2) gingival crevicular fluid (GCF) is a valuable oral fluid, but the association of GCF proteins and dental caries remains underexplored and the GCF proteomic profile in the context of dental caries has not yet been characterized. - Source: PubMed
Publication date: 2026/04/16
Yang XueZhao TingYu PingboCai DanLiao RijingCai YanWang Jun - Periodontitis (PD) is a prevalent chronic inflammatory disorder in adults, and moderate-to-severe PD (Stage II-III/IV) may accelerate brain aging and neurodegenerative changes via the peripheral-central immune-neural axis, although the molecular connections and mechanisms of interaction have yet to be fully elucidated. This study sought to identify senescence-associated molecules potentially shared by PD and Alzheimer's disease (AD) using integrated transcriptomic analysis, machine learning, and RNA interference assays, and to further assess the role of TMEM140 in linking PD to brain aging. - Source: PubMed
Publication date: 2026/04/22
Zhao HaoRanWang HongTaoLi WangXingSu RuiLi JingLiu YanWang Lei - - Source: PubMed
Publication date: 2026/05/06
Wang YukaiZhang WeiLiu YongshuoTang Xiaolong - - Source: PubMed
Publication date: 2026/05/07
Li HaixiaDeng XinzhouWang FangNiu YanlinRuan PengfeiGong LiLuo MingLuo ZhiguoCao Nan