Ask about this productRelated genes to: MMP3 protein
- Gene:
- MMP3 NIH gene
- Name:
- matrix metallopeptidase 3
- Previous symbol:
- STMY1, STMY
- Synonyms:
- -
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: MMP3 protein
Related articles to: MMP3 protein
- Plant-derived bioactive compounds are increasingly sought after in the cosmetics and pharmaceutical industries, prompting the development of sustainable production methods. This study explored the potential of Cannabis sativa adventitious root cultures to produce extracellular vesicle-like nanoparticles (CA-NPs) and investigated their protective effects against UVB-induced damage in human keratinocytes. - Source: PubMed
Publication date: 2026/06/15
Bak Dong HoPark Su HyunRyu Young BaeKim Cha YoungJeong Jae CheolKim Woo Sik - This study investigated the effects of Aureusidin on extracellular matrix (ECM) degradation and pyroptosis of chondrocytes in osteoarthritis. Network pharmacology, molecular docking, and pull-down assays were initially conducted to explore the target of Aureusidin. Subsequently, Sprague-Dawley rats underwent anterior cruciate ligament transection (ACLT) received oral administration of Aureusidin. Cartilage damage was evaluated histopathologically by H&E and Safranin O-fast green staining. Primary rat chondrocytes were treated with Aureusidin under IL-1β stimulation. Pyroptotic morphology was observed under light microscopy. Propidium iodide staining and flow cytometry were conducted to evaluate membrane rupture. The expression of markers associated with ECM degradation and pyroptosis was analyzed by qRT-PCR, Western blot, immunohistochemistry, and ELISA. Caspase-3 was identified as a target for Aureusidin. Aureusidin (5, 10, 20 mg/kg) alleviated ACLT-induced cartilage damage and ECM degradation. It reduced the OARSI score and serum levels of CTX-II and COMP, while upregulating the expression of Col2a1 and Acan, and downregulating Adamts5, Mmp13, and Mmp3. Aureusidin also mitigated atypical pyroptosis, evidenced by inhibited expression of GSDME-N, Caspase-3, and Cleaved-Caspase-3, and decreased levels of IL-1β and IL-18. In IL-1β-stimulated primary chondrocytes, Aureusidin (5, 10, 20 μM) attenuated ECM degradation and Caspase-3/GSDME-mediated pyroptosis. Treating chondrocytes with the Caspase-3 inhibitor Z-DEVD-FMK under IL-1β-stimulated conditions alleviated ECM degradation and pyroptosis, but the additional application of Aureusidin did not provide further inhibition. Aureusidin has the potential to inhibit ECM degradation and Caspase-3/GSDME-mediated chondrocyte pyroptosis during osteoarthritis progression. Its therapeutic effects are dependent on binding to and modulating the Caspase-3. - Source: PubMed
Publication date: 2026/06/15
Feng ShangxiangSong KunZhang HaoWang ZhuoqunZhao YuchiZhao ZhongyuanWan Chao - Platelet-rich plasma (PRP) is widely used in regenerative medicine due to its high concentration of bioactive growth factors; however, its short shelf life limits its clinical applicability. Lyophilization has been proposed to extend PRP stability, but its impact on biological efficacy remains unclear. This study evaluated whether lyophilization alters the biochemical composition and regenerative function of PRP derived from expired platelet units unsuitable for transfusion. - Source: PubMed
Solouki AminManoochehrabadi TaherehMohammadi Mohammad HosseinRahimi Hamid RezaHamidpour Mohsen - The complex microenvironment of articular cartilage defects, characterized by oxidative stress and infection risk, poses a major challenge for regenerative medicine. Here we report a molecular engineering strategy to transform mung bean protein (MBP), an abundant and sustainable plant protein, into a multifunctional, microenvironment-relevant bioink. By sequentially grafting ε-polylysine (EPL) and methacryloyl groups onto the MBP backbone, we created a family of photocurable derivatives (MEM) with tunable methacrylation degrees. Three variants were obtained: MEM-A (65% methacrylation), MEM-B (78% methacrylation), and MEM-C (86% methacrylation). The hydrogels exhibit rapid rheological gelation (<2 s, defined by the '-″ crossover), tunable mechanical properties (20-60 kPa compressive modulus), and a porous architecture (100-150 μm pore size, 70-80% porosity) conducive to cell growth. The resulting MEM hydrogels integrate broad-spectrum antimicrobial activity (>90% bacterial killing), enhanced antioxidant capacity (>51% radical scavenging), and excellent DLP printability (>87% printing accuracy). Among these, the MEM-B hydrogel supports chondrocyte viability, upregulates cartilage-specific genes (), and downregulates oxidative stress markers (). In a rat osteochondral defect model, MEM-B promoted robust cartilage regeneration with superior ICRS scores and tissue integration compared to GelMA controls. This work establishes a design paradigm for converting underutilized plant proteins into multifunctional bioinks that actively engage with pathological microenvironments, opening sustainable avenues for next-generation regenerative biomaterials. - Source: PubMed
Publication date: 2026/06/13
He XiaoliZhou ZhengZhu ShuaiChen XinYan ShipingYang LingxiuLei JiajieDai YaoLiu Hairong - Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pathological features such as chondrocyte loss and cartilage matrix degradation. Superficial zone chondrocytes (SFC), located in the outermost layer of articular cartilage and in direct contact with synovial fluid, are the first to respond to mechanical stress and friction. In this study, SFC were isolated and identified in vitro, and their proliferatives and anti-apoptotic properties were examined. Additionally, an early OA inflammatory environment was successfully simulated in cell experiments, demonstrating that inflammatory conditions reduce stemness-associated marker expression in SFC, activate multiple inflammatory pathways, and promote MMP3 expression. When SFC were subjected to cyclic mechanical stretching under inflammatory conditions, increased expression of the mechanosensitive channel Piezo1, enhanced calcium-associated mechanotransduction sensitivity, and disruption of the cytoskeleton were associated with aggravated catabolic responses and apoptosis under inflammatory mechanical stimulation. These findings elucidate the role of SFC in early OA pathogenesis and provide insight into early OA pathogenesis and suggest potential directions for mechanism-based intervention. - Source: PubMed
Publication date: 2026/06/12
Liu FengruiDing XuetingLi PengcuiYuan JieGuo LiZhao SenWu GaigeWei Xiaochun