Ask about this productRelated genes to: Akt1 protein
- Gene:
- AKT1 NIH gene
- Name:
- AKT serine/threonine kinase 1
- Previous symbol:
- -
- Synonyms:
- RAC, PKB, PRKBA, AKT
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: Akt1 protein
Related articles to: Akt1 protein
- The PI3K-AKT-mTOR signaling pathway plays a central role in immune regulation and has been implicated in autoimmune diseases. However, the contribution of genetic variation within key components of this pathway to microscopic polyangiitis (MPA) remains incompletely understood. - Source: PubMed
Publication date: 2026/04/23
Li LizhenYang JingXue ChaoChu LiepengZhong HuanRao JinlanShe ChangTan LijuanFang XiShen ShaoxiaChen Yinyin - The mC modification is one of the widely occurring modifications on RNA. In recent years, mC modification on RNA has increasingly become a focal point in cancer research. Nevertheless, investigating scientific and quantitative research on the publication trends in this field can help us understand the research background and emerging hotspots, providing insights for targeting RNA mC sites in cancer therapy. Co-occurrence analyses and visualizations, including authorship, keywords, genes and diseases, were performed using VOSviewer. CiteSpace was used to identify bursting institutions, keywords and references. R packages, including clusterProfiler, enrichplot and ggplot2, were used to visualize the enrichment results of GO and KEGG. The top contributors to this field were the United States and China, and the journals with the most publications were and . The most common keyword was "mC methylation" and the most related genes were "NSUN2", "AKT1" and "METTL3". This study conducted a bibliometric analysis covering the development process of RNA mC modification in cancer progression, identifying the countries, institutions, authors, journals, and publications in this field. Additionally, we found that the genes most closely associated with mC are likely to play a significant role in the process of viral oncogenesis. These findings provide a comprehensive overview of RNA mC modification during cancer research and insights into RNA mC-tageted cancer therapy. - Source: PubMed
Yao PeipeiChen FeiZhang NanUllah HafizShi XuecongZhong XinglongZhou Li - We herein report the synthesis, and antiproliferative evaluation of a novel series of N(4)-substituted 5,7-dibromoisatin thiosemicarbazones (TSCs). Structure and activity based approach was used to synthesize derivatives: N(4)-pyrrolidinyl (L1), N(4)-piperidinyl (L2), N(4)-morpholinyl (L3), N(4)-methyl (L4), and N(4)-ethyl (L5). The compounds were characterized by elemental analysis, FTIR, H NMR, C NMR, UV-Vis spectroscopy, HRMS and single crystal X-ray analysis. The antiproliferative activity of the synthesized TSCs was evaluated in a dose-dependent manner against breast (MCF-7, MDA-MB-231), skin (A431), lung (A549, NCI-H460), and prostate (PC3) cancer cell lines. L3 and L5 exhibited enhanced cytotoxicity in the low micromolar range of IC; 1.16-2.47 µM. Notably, L5 showed superior potency in MCF-7 cells with IC; 1.16 µM compared to the FDA-approved thiosemicarbazone Triapine with IC; 4.27 µM, while displaying minimal toxicity toward non-tumorigenic MCF-10a breast epithelial cells with selectivity index > 86.20, consistent with ADMET predictions. Molecular docking and molecular dynamics simulations demonstrated stronger binding affinity and greater complex stability of L5 with PTOV1 compared to the FDA approved drug Lenalidomide, supporting L5 drug likeness and therapeutic potential. Mechanistic investigations through functional assays like crystal violet assays, flow cytometry, immunoblotting, and microscopy revealed that L5 induces G0/G1 cell-cycle arrest, suppresses cell migration, invasion, colony formation, 3D spheroid growth, and promotes apoptotic cell death in MCF-7. Western blot analysis provided direct mechanistic evidence that L5 downregulates PTOV1 expression, leading to reduced phosphorylation of AKT1/2/3 and c-Jun, reduced β-catenin nuclear translocation, and decreased MMP-2 expression. L5 enhanced H2AX phosphorylation, suppressed PARP and BCL-XL levels, and increased active caspase-3 driving L5 induced apoptosis. This study identifies L5 as a potent anticancer agent in breast cancer, acting through modulation of the PTOV1-AKT-β-catenin signaling axis, and highlights PTOV1 as a promising therapeutic target. - Source: PubMed
Kumar PiyushChaudhary UpendraMahiya KuldeepChandra AnshumanGoel Vijay KumarPokharel Yuba RajYadav Paras Nath - Periodontitis is a chronic inflammatory disease featured by progressive destruction of periodontal supporting tissues. Accumulating evidence indicates that gut microbiota-derived metabolites modulate periodontal inflammation via the gut-periodontal axis, yet the underlying mechanisms and therapeutic targets remain largely unknown. - Source: PubMed
Lin HaitaoZhang JueWen WenjieChen Liang - Acute lung injury (ALI) is a severe, life-threatening inflammatory condition, characterized by uncontrolled neutrophilic inflammation and tissue damage. That emphasized the urgent need for innovative pharmacologic therapies. The aim of this study was to investigate the effects of Celastrol, a major bioactive compound extracted from the Thunder of God Vine, and the underlying mechanisms of its impact on ALI. - Source: PubMed
Publication date: 2026/05/08
Zhang YuYang YunLin ZhifengChen RikenQiang XinhuaLi ChangGuo WeiguangCao JunYe YinongZhou Lixin