Ask about this productRelated genes to: GDF9 protein
- Gene:
- BMP15 NIH gene
- Name:
- bone morphogenetic protein 15
- Previous symbol:
- -
- Synonyms:
- GDF9B
- Chromosome:
- Xp11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-29
- Date modifiied:
- 2016-10-05
- Gene:
- GDF9 NIH gene
- Name:
- growth differentiation factor 9
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-09-12
- Date modifiied:
- 2015-08-25
Related products to: GDF9 protein
Related articles to: GDF9 protein
- Cryopreservation of ovarian tissue is an important technique for preserving the reproductive potential of valuable and endangered species and plays a critical role in establishing genetic resource banks. However, the success of ovarian tissue cryopreservation depends largely on the choice of cryoprotective agent (CPA), which must balance protection against intracellular ice formation with potential cytotoxic effects. In feline ovarian tissue, the dense collagen-rich stromal architecture may further limit CPA diffusion, thereby influencing cryopreservation efficiency. This study aimed to evaluate the effects of two commonly used penetrating CPAs, dimethyl sulfoxide (MeSO) and ethylene glycol (EG), individually and in combination, on cellular apoptosis and the preservation of key oocyte-secreted factors (OSFs), growth differentiation factor-9 (GDF9) and bone morphogenetic protein-15 (BMP15), following slow-freezing cryopreservation of feline ovarian tissue. - Source: PubMed
Publication date: 2026/03/17
Thatsanabunjong FueangratPanyaboriban SaritvichKanthawat SupapitRaksaseri PrompornThuwanut PaweenaSrisuwatanasagul KongkiatSrisuwatanasagul Sayamon - Premature ovarian insufficiency (POI) causes irreversible follicular depletion and infertility, and current treatments do not reliably preserve fertility after gonadotoxic chemotherapy. Recent work suggests extracellular vesicles from embryonic stem cells (ESC-EVs) can promote tissue regeneration, but it is unknown whether ESC-EVs can prevent or reverse POI, and which cellular programs they engage to restore ovarian function. - Source: PubMed
Publication date: 2026/04/23
Li XiangMa RuZhao MantongGuo YuHu XueminLiu JinfengYu HuaxinLi ZongjinDu XueLiu Na - This study investigated the effects of chemically synthesized gold nanoparticles (GNPs) and green gold nanoparticles (gGNPs) derived from extract on antrum diameter and the expression of genes associated with follicular development in NMRI mice. Female mice were treated with GNPs and gGNPs at concentrations of 10, 50, and 100 µg/mL. Antrum diameter in ovarian follicles was measured using ImageJ software. Gene expression levels of BMP-15, GDF-9, SOD, and GPx were quantified via real-time PCR.Treatment with gGNPs at 100 µg/mL significantly increased the antrum diameter of secondary follicles compared to GNPs (p ≤ 0.05), while no significant changes were observed in grafted follicles. A dose-dependent upregulation of BMP-15, GDF-9, GPx, and SOD was observed in both GNP and gGNP groups, with gGNPs eliciting stronger effects across all genes (p ≤ 0.05). The findings suggest that -mediated green synthesis enhances the biological activity of GNPs, particularly in promoting follicular development and antioxidant gene expression. Although mechanistic pathways were not explored in this study, future research should address these gaps and evaluate long-term safety and therapeutic potential. - Source: PubMed
Publication date: 2025/07/28
Abdollahi MohammadrezaZangooei MohammadGhorbani ParishadMahmoudian Reihaneh AlsadatMansouri Atena - Alpha-Ketoglutarate (AKG), a pivotal metabolite in the tricarboxylic acid cycle, possesses notable antioxidant properties that reduce oxidative stress. While its benefits in in-vitro maturation (IVM) of porcine, murine, and ovine oocytes are documented, its role in bovine oocytes-especially that derived via ovum pick-up (OPU)-remains unexamined. This is the first study to use OPU-derived oocytes from Sahiwal cattle (Bos indicus) to test 15 µM, 30 µM, and 45 µM AKG concentrations during IVM. Key parameters assessed included oocyte maturation rate, cumulus expansion, intracellular levels of Glutathione (GSH) and reactive oxygen species (ROS), and expression of oxidative stress (NRF2), apoptotic (BAX, BCL2), and maturation (BMP15, GDF9) genes. Results showed that 30 µM AKG significantly enhanced oocyte maturation (77.77% vs 56.09%, P < 0.05, lowered ROS levels (27.96 ± 4.388 vs 49.01 ± 1.870, P < 0.01), and increased GSH accumulation (25.01 ± 0.8467 vs 17.99 ± 1.586, P < 0.001). Gene expression analysis in denuded oocytes revealed significant upregulation of GDF9, BCL2, and NRF2 in the 30 µM group, indicating improved maturation, apoptosis modulation, and oxidative stress reduction. These findings highlight the potential of optimizing AKG in IVM protocols to enhance oocyte quality and developmental competence in bovine reproductive technologies. - Source: PubMed
Publication date: 2026/03/27
Shrikant Rele GauriChouhan V SWarghat ChinmayYadav PoonamSharma ShwetaSamad H AKumar BrijeshMaurya V PSingh Gyanendra - Premature ovarian insufficiency (POI) often leads to infertility and long-term health complications. Processed Polygonum multiflorum Thunb. (PM) is a traditional medicinal and edible plant widely used in health supplements and herbal medicine. It has shown potential in mitigating ovarian aging but its mechanisms against POI remain unclear. - Source: PubMed
Publication date: 2026/03/10
Li JinhongLiu YangYou HaolingLi SongLin ChangZhu Can