Ask about this productRelated genes to: GDF3 protein
- Gene:
- GDF3 NIH gene
- Name:
- growth differentiation factor 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-23
- Date modifiied:
- 2016-10-05
Related products to: GDF3 protein
Related articles to: GDF3 protein
- The coordination of cell migration and proliferation is essential for embryogenesis and tissue homeostasis. However, the classical gradient signaling model is insufficient to explain how stable mitogenic signaling is maintained within migratory cells. Here, we reveal that primordial germ cells (PGCs) in zebrafish employ migrasomes-vesicular organelles formed during migration-to couple their proliferation with migration, ensuring germline expansion. Migrasomes, generated at retraction fibers via tspan7-dependent biogenesis, deliver the growth factor GDF3 specifically to neighboring PGCs through contact-dependent interactions. GDF3 activates the TGF-β receptor acvr1ba, driving proliferation in a spatiotemporally restricted manner. This homocrine signaling mechanism allows migrating PGCs to autonomously sustain proliferation, circumventing signal dilution in embryonic environments. This work uncovers migrasomes as a bridge linking migration and proliferation, with implications for understanding collective cell behaviors in development and disease. - Source: PubMed
Publication date: 2026/04/10
Liu BoqiJiang ZhengSong WenhaoZhai ZhaochengLi YaqiZhang WeiyingMeng AnmingYu Li - Mesenchymal stromal cells (MSCs) of various origins promote regeneration through paracrine signaling, immune modulation, and angiogenesis support. Premature ovarian failure (POF) is an excellent model to study coordinated ovarian and uterine repair, as cytotoxic injury simultaneously depletes ovarian follicles and impairs uterine receptors, resulting in infertility. - Source: PubMed
Borutinskaitė Veronika ViktorijaKrastinaitė IndrėValatkaitė ElvinaZentelytė-Vilkė AistėNavakauskienė Rūta - Amorphous glass scintillators are designed, and the radio-luminescence and density are modulated by GdF concentration. The glass density is enhanced to 4.62 g/cm, which is higher than oxyfluoride glass ceramics, and increases the absorption coefficient for X-rays. The radio-luminescence intensity of optimum glass is higher than that of traditional glass scintillators and even 22 times higher than commercial BiGeO (BGO) crystal. Clear imaging photos of objects such as an earphone, metal springs, a peanut, and an integrated circuit chip are all obtained by using the designed glass as a scintillator with a spatial resolution of 20.4 lp/mm. This work provides a strategy for engineering an excellent glass scintillator for clear X-ray imaging. - Source: PubMed
Long YiZhang HaoyanLuo CanrongSun Li-PengFang ZaijinGuan Bai-Ou - Aging is characterized by amplified inflammation, including proinflammatory macrophages and increased susceptibility to endotoxemia. Here we uncover a mechanism by which macrophages maintain their inflammatory phenotype through autocrine GDF3-SMAD2/3 signaling, which ultimately exacerbates endotoxemia. We show that inflammatory adipose tissue macrophages display an age-dependent increase in GDF3, a TGFβ-family cytokine. Lifelong systemic or myeloid-specific Gdf3 deletion leads to reduced endotoxic inflammation. Using pharmacological interventions to modulate the GDF3-SMAD2/3 axis, we demonstrate its role in regulating the inflammatory adipose tissue macrophage phenotype and endotoxemia lethality in old mice. Mechanistically, single-cell RNA sequencing and assay for transposase-accessible chromatin with sequencing analyses suggest that GDF3 induces a shift toward an inflammatory state by limiting methylation-dependent chromatin compaction. Leveraging human adipose tissue samples and 11,084 participants from the atherosclerosis risk in communities study, we validate the relevance of GDF3 to aging in humans. These findings position the GDF3-SMAD2/3 axis as a critical driver of age-associated chromatin remodeling and a promising therapeutic target for mitigating macrophage-related inflammation in aging. - Source: PubMed
Publication date: 2025/12/15
Jang In HwaCarey AnnaKruglov VictorNguyen KatieMisialek Jeffrey RCholensky Stephanie HSmith Declan MBai SuxiaNottoli TimothyBernlohr David ALutsey Pamela LCamell Christina D - We synthesized europium-doped gadolinium fluoride (GdF:Eu) scintillating nanoparticles conjugated to methylene blue (MB) for singlet oxygen (O) generation in X-ray-induced photodynamic therapy (X-PDT). The impact of MB conjugation on GdF:Eu nanoparticles (GdF@B) was analyzed, including size, polydispersity, and surface charge. Time-resolved photoluminescence analysis demonstrated that binding of MB to the nanoparticle surface is essential for enabling efficient resonant energy transfer (ET) from the GdF:Eu core to the MB molecules. ET efficiencies ≥97% were obtained. O production exhibited energy- and dose-dependent behavior under varying radiation conditions. MTT assays demonstrated relative toxicity to LLC lung cancer mouse cells, while maintaining good tolerability in A549 human cancer cells. Clonogenic assays showed significant cytotoxicity in A549 cells only after X-ray exposure, confirming a reduced clonogenic survival. Survival fraction curves were analyzed using the linear-quadratic model, the sensitization enhancement factor, and the dose enhancement factor, highlighting the contributions of both the high atomic number of GdF:Eu cores and O generation. The findings indicate that GdF@B enables deep-tissue ROS generation, overcoming light penetration limitations in traditional PDT. Additionally, these nanoparticles show potential to enhance radiotherapy efficacy in both conventional fractionated protocols and advanced radiosurgery techniques, offering a promising cancer treatment nanoplatform. - Source: PubMed
Publication date: 2025/09/04
Isikawa Mileni MMuradova ZeinafMorris TobyLessa João V VBorges Fernanda HGonçalves Rogéria RBerbeco Ross IGuidelli Eder J