Ask about this productRelated genes to: PLGF protein
- Gene:
- PGF NIH gene
- Name:
- placental growth factor
- Previous symbol:
- PGFL
- Synonyms:
- PLGF, PlGF-2, PlGF, SHGC-10760, D12S1900, PIGF
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-14
- Date modifiied:
- 2016-05-20
Related products to: PLGF protein
Related articles to: PLGF protein
- The microbiota-gut-joint axis influences systematic and local inflammation the gut microbiota. Our previous investigations have revealed that hyaluronic acid (HA) with specific molecular weight (MW) affects the human gut microbiota in a simulated batch fermentation system. However, the structure-property relationships and mechanism by which HA alleviates rheumatoid arthritis (RA) by modulating the gut microbiota remain unexplored. In this study, collagen-induced arthritis (CIA) Wistar rats received HAs of different MWs (2 kDa, 300 kDa, 3000 kDa) by oral gavage. HAs MW-dependently improved osteochondral health and cartilage injury, characterized by alleviated foot swelling, enhanced motor capacity and reduced pro-inflammatory mediator levels. Muti-omics analysis of the gut microbiota and joint transcriptomic studies revealed that HAs regulate the gut microbial composition, interactions, phenotype and intestinal barrier functions. High-MW HA upregulated beneficial bacteria (, , and ) and arginine and proline metabolism while inhibiting harmful bacteria (, and the group) and ECM-receptor interactions. Furthermore, alleviation of RA symptoms and similar characteristics of the gut microbiota were observed in a pseudo-germ-free (PGF) rat model after fecal microbiota transplantation (FMT) from donors of the high-MW HA group. These findings proved that the gut microbiota mediates the anti-rheumatic effect of HAs on the microbiota-gut-joint axis, providing a new opportunity to understand the structure-property relationships in RA therapy. - Source: PubMed
Publication date: 2026/09/01
Zhu HongkangGao XinweiZhou XinnuoQian HeYang ZhenquanLiu Yu - This study aims to examine the relationship between the concentrations of different aqueous humour cytokine and the Central retinal thickness (CRT), the area of the Foveal avascular zone (FAZ) and the vascular density of superficial capillary plexus (SCP-VD) in patients with Central Retinal Vein Occlusion-Macular Edema (CRVO-ME) through a prospective clinical investigation. - Source: PubMed
Publication date: 2026/08/11
Gao JiePang HuiwenZhang WeijieFeng MaojuanWang Tao - The Jishen Black pig is a synthetic breed incorporating the genetic backgrounds of Chinese indigenous pigs and Western lean-type pigs. The objective of this study was to characterize phenotypic variation, estimate genetic parameters, and identify genomic loci associated with rib number (NR) and the total number of thoracolumbar vertebrae (NTLV) in Jishen Black pigs. NR, NTLV, and lumbar vertebra number (NLV) were measured in 389 pigs, and genotyping was performed using a 70K SNP chip. Genetic parameters were estimated using HIBLUP, and genome-wide association studies (GWAS) were conducted using the MLM and BLINK models in GAPIT v3.0. The mean values of NR, NTLV, and NLV were 14.88, 20.94, and 6.05, respectively, and their heritability estimates were 0.568, 0.493, and 0.140, respectively. GWAS identified a shared major association peak for NR and NTLV on SSC7 at 91.19-98.15 Mb, centered on and the adjacent linkage region, among which the loci at 96.12 Mb, 96.56 Mb and 97.79 Mb are NR-specific loci. Additional signals included on SSC6 and on SSC14 for NTLV, together with NR-specific loci on SSC7 at 111.59 Mb and on SSC8. Database annotation indicated that several significant SNPs overlapped with records for rib number, carcass length, loin muscle area, backfat thickness, or teat number. This study identifies major genomic regions associated with vertebral-number traits in Jishen Black pigs and expands current knowledge of their genetic basis. - Source: PubMed
Publication date: 2026/08/03
He YuDong FengyiJin LongNing JiayiLiu WuyangFeng ChengyueZhu ZhikaiSun HanZhang XiaoranChen ChangyiBie LuyaoSun BoxingSun HaoBai Chunyan - Hypertensive disorders of pregnancy (HDPs) such as preeclampsia are associated with adverse maternal and perinatal outcomes and related to high soluble fms-like tyrosine kinase-1 (sFlt-1) levels and low placental growth factor (PlGF) levels. While these biomarkers are used for predicting and diagnosing preeclampsia, their impact on postnatal neonatal nutritional management, growth, and body composition is not well-established. Therefore, we aimed to evaluate the association between maternal angiogenic markers, neonatal growth, and body composition. : This study represents a secondary analysis of a prospective cohort study conducted at the Medical University of Vienna. Women with HDP were included in the analysis, and infants were stratified by gestational age at birth into preterm (<37 weeks of gestation) and term (≥37 weeks of gestation) groups. Maternal angiogenic markers were routinely measured at the time when HDP was first suspected, and neonatal body composition was assessed at term-equivalent age. : A total of 335 infants were screened, 94 of which (preterm: = 72; term: = 22) were included. Higher sFlt-1/PlGF ratios were significantly correlated with lower fat-free mass (FFM) z-scores (rs = -0.408; = 0.004), but not with fat mass (FM) z-scores ( = 0.21), weight ( = 0.19), length ( = 0.31), or head circumference z-scores ( = 0.32) in preterm infants. In a linear regression model adjusted for potential neonatal confounders, higher sFlt-1/PlGF ratios were independently and significantly associated with lower FFM in preterm infants (median: -0.10, 95% CI: -0.2, 0.00; = 0.036). In term infants, sFlt-1/PLGF ratios were not significantly correlated with FFM ( = 0.86), FM z-scores ( = 0.41), weight ( = 0.10), length ( = 0.12), or head circumference z-scores ( = 0.2). : These findings suggest that the sFlt-1/PLGF ratio is not only a well-established marker of HDP severity during pregnancy but may also be associated with adverse effects on body composition in preterm infants, particularly in fat-free mass (FFM). - Source: PubMed
Publication date: 2026/08/14
Schirwani-Hartl NawaBinder JuliaPalmrich PilarLongford NicholasCalek ElisabethHarreiter KarinThajer AlexandraBerger AngelikaKiss HerbertBinder Christoph - Chronic hyperglycemia disrupts the retinal neurovascular unit, making diabetic retinopathy (DR) the leading cause of adult vision loss. The hallmarks of DR include pathological angiogenesis, vascular leakage, and neurodegeneration. Although vascular endothelial growth factor A (VEGF-A) is a key mediator of these abnormalities and anti-VEGF therapies remain the standard treatment, many patients exhibit incomplete responses, and these therapies do not adequately address inflammation or fibrosis. Placental growth factor (PlGF), a VEGF family member that selectively binds to VEGFR1, has emerged as an important contributor to retinal neovascularization, vascular dysfunction, barrier breakdown, and microinflammation in DR. Unlike VEGF-A, PlGF modulates distinct responses among retinal neurons, glial cells, and vascular cells, with its abnormal expression closely associated with disease progression from non-proliferative to proliferative DR. This review summarizes the context-dependent functions of PlGF in the diabetic retina, compares PlGF-VEGFR1 signaling with VEGF-A-VEGFR2 pathways, and discusses preclinical and clinical evidence supporting PlGF inhibition as a potential complementary approach to existing anti-VEGF therapy. - Source: PubMed
Publication date: 2026/08/17
Kim JongminJu Won-KyuWon Jae Yon