Ask about this productRelated genes to: ApoC1 protein
- Gene:
- APOC1 NIH gene
- Name:
- apolipoprotein C1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: ApoC1 protein
Related articles to: ApoC1 protein
- Laryngeal squamous cell carcinoma (LSCC) remains a major clinical challenge with limited therapeutic options and unsatisfactory outcomes. Hypoxia-induced stress responses are known to contribute to tumor progression, immune remodeling, and therapeutic resistance. However, the cell type-specific hypoxia-associated transcriptional programs within the immune and stromal microenvironment of LSCC remain incompletely understood. - Source: PubMed
Publication date: 2026/08/04
Du HuihuiWang YatingLin RenyuYu JiaqiZhu Kuaiquan - Early studies have suggested that apolipoprotein C1 (APOC1) functions as an oncogenic factor in papillary thyroid carcinoma (PTC), where it promotes tumor cell proliferation. Here, we focus on the regulatory mechanisms underlying APOC1-mediated PTC cell growth, with particular attention to histone modification-driven changes in APOC1 expression and disease progression. Our bioinformatics analysis revealed that APOC1 was differentially expressed in PTC and might be involved in tumor-related biological processes. The influence of APOC1 on PTC cell growth and glycolysis was studied. The impact of APOC1-induced glycolytic reprogramming on PTC cell proliferation was assessed. Cells were treated with the a selective p300/CBP histone acetyltransferase inhibitor (C646) and the histone deacetylase inhibitor sodium butyrate (NaB) to modulate histone acetylation levels. Subsequently, chromatin immunoprecipitation (ChIP) assays were carried out to assess the role of histone modifications in APOC1 expression regulation. Finally, nude mouse xenograft models were used to confirm the oncogenic role of APOC1 in PTC development. Bioinformatics and experimental analyses confirmed that APOC1 expression showed a strong correlation with glycolysis-related genes and PTC cell proliferation was influenced by changes in glycolysis. Meanwhile, APOC1 expression was activated by H3K27ac. Xenograft models were subsequently used to further validate these findings in vivo. H3K27ac-mediated activation of APOC1 may promote glycolytic reprogramming in PTC cells, thereby driving their proliferation. - Source: PubMed
Publication date: 2026/07/15
Song JiayinZuo SuweiWang YuanyuanSun SinuoZhou YanmengLiu ShiboLi YanpingLiu YachaoXue GangLin XuWu Jingfang - Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region. Apolipoprotein C1 (APOC1) has been identified as an oncogene in multiple tumors, while its role and molecular mechanism in OSCC remain incompletely understood. - Source: PubMed
Publication date: 2026/08/11
Sun QiuwangyueZhang XiZhang Wei - Dyslipidemia, inflammation and angiogenesis pathways contribute to the genetic susceptibility to diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). This study investigated the association of common genetic variants; Apolipoprotein C1 (APOC1) rs4420638, C-C chemokine receptor type 5 (CCR5) rs1799987, C-X-C motif chemokine ligand 8 (CXCL8) rs4073, Matrix metallopeptidase 9 (MMP9) rs17576, Erythropoietin (EPO) rs1617640 and Vascular Endothelial Growth Factor A (VEGFA) (rs833061 and rs3025039) with DN susceptibility in Tunisian T2DM patients. - Source: PubMed
Publication date: 2026/08/10
Moussa AmiraMethnani JabeurHassine RefkaAbbes HouwaidaAmmar MariemBjaoui WidedTriki SoniaKoubaa AfifaAmor DorraRejeb Nabila BenNeffati FadouaNajjar Med-FadhelBouslama AliOmezzine Asma - Apolipoprotein C1 (APOC1) is aberrantly overexpressed in multiple cancers, but its role in pancreatic adenocarcinoma (PAAD) and the tumor microenvironment remains unclear. Here, we investigated the expression and function of APOC1 in tumor-associated macrophages (TAMs) in PAAD. Analysis of public single-cell datasets revealed that APOC1 is predominantly expressed in PAAD-associated macrophages and is significantly upregulated in TAMs compared to M0 macrophages. Functional studies demonstrated that APOC1 promotes M2-polarized immunosuppressive macrophage polarization and consequently enhances PAAD cell proliferation, migration, and resistance to cell death in vitro and in vivo. Mechanistically, APOC1 exerts its effects through two distinct pathways: (i) it activates the PPAR-γ signaling pathway in macrophages to drive M2 polarization; and (ii) it is secreted by macrophages via exosomes and transferred to PAAD cells, where it directly interacts with KEAP1 to stabilize NRF2, leading to suppression of ferroptosis. Targeting APOC1 in TAMs sensitizes PAAD cells to ferroptosis and synergizes with gemcitabine (GEM), a first-line chemotherapeutic agent, as evidenced by enhanced anti-proliferative, anti-migratory, and pro-apoptotic effects in vitro and reduced tumor growth in vivo. Collectively, our findings identify APOC1 as a critical regulator of M2 polarization and ferroptosis resistance in PAAD and suggest that targeting APOC1 in TAMs represents a potential therapeutic strategy to overcome GEM resistance. - Source: PubMed
Publication date: 2026/08/07
Wang YueGao QingXie YanFan YaoyaoYang HuainaWu ChenchenMao MeiyiJiang KaitaoZhang QinBao HaibiaoLi Xihan