Ask about this productRelated genes to: VEGFD protein
- Gene:
- VEGFD NIH gene
- Name:
- vascular endothelial growth factor D
- Previous symbol:
- FIGF
- Synonyms:
- VEGF-D
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-27
- Date modifiied:
- 2016-10-05
Related products to: VEGFD protein
Related articles to: VEGFD protein
- Heterotopic ossification (HO) is a debilitating condition that commonly occurs after musculoskeletal injury and is characterized by the formation of bone in soft tissues. Despite advances in understanding its pathogenesis, effective therapies to reverse established heterotopic bone remain lacking. While lymphatic vessels are associated with the destruction of bone in rare diseases such as Gorham-Stout disease, their effect on HO has not been widely explored. Here, we use transgenic mice to determine whether targeted expression of the lymphatic growth factor VEGF-D can promote the therapeutic resorption of bone in a mouse model of HO. We show that control mice lack lymphatic vessels in heterotopic bone. In contrast, -overexpressing () mice develop lymphatic vessels in heterotopic bone and form significantly less heterotopic bone than control mice. Additionally, we demonstrate that VEGF-D overexpression or local delivery promotes the therapeutic resorption of established heterotopic bone. Mechanistically, we show that the transition of myeloid cells to osteoclasts and osteoclast-mediated bone resorption are enhanced in mice. These findings reveal a previously unrecognized role for lymphatic vessels in regulating heterotopic bone resorption and identify VEGF-D-mediated lymphangiogenesis as a promising therapeutic strategy for HO. - Source: PubMed
Publication date: 2026/05/05
Vishlaghi NedaGriswold-Wheeler DanielleKorlakunta SnehaVallejo AngelicaMittal MonishaSun YuxiaoZhao PengYang Yunzhi PeterRutkowski Joseph MLevi BenjaminDellinger Michael - There are relatively well-substantiated concepts regarding the differences in the clinical course of metastatic colorectal cancer depending on the primary tumor localization: right- and left-sided (including rectal). However, many clinical trials demonstrate clear differences in the selected efficacy of adjuvant chemotherapy in the treatment of rectal versus colon cancer. We hypothesize that there are significant differences in long-term outcomes between patients with metastatic rectal cancer (RC) and those with left-sided colon cancer (LSCC) that may depend on the genetic profile of the primary tumor. - Source: PubMed
Publication date: 2026/04/15
Semenov N NZhukova L GYakovlev V A - The current number of emerging contaminants worldwide may reach tens of thousands. However, research on the extra-pulmonary toxicity induced by combined exposure of extremely low-dose emerging pollutants remains extremely limited. This study examined testicular injury induced by intratracheal instillation of two prevalent and frequently co-occurring emerging contaminants at ambient levels: polystyrene nanoparticles (PS) and perfluorooctane sulfonate (PFOS). With a 3 × 3 factorial design, male mice were intratracheally instilled with PS (0, 1.5 and 7.5 mg/kg) and/or PFOS (0, 5 and 25 μg/kg) once a week for 4 weeks. The instillation of PS in combination with PFOS induced more severe testicular histopathological injury, impairment of sperm counts and quality, reduced serum testosterone (T) levels and disruption of the blood-testis barrier (BTB). Furthermore, the testicular transcriptomic analysis identified the differentially expressed genes (DEGs) in the PS and PFOS co-exposure group, especially with Ldlr and Vegfd downregulation, and the DEGs were significantly enriched in vascular morphogenesis and development pathways and cholesterol metabolism pathways. In parallel, the protein expression of LDLR was decreased, the expression of testicular vascular endothelial markers (CD31 and VEGF) and tight junction proteins (ZO-1 and OCLN) was significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Moreover, the testicular steroidogenic enzymes (StAR, CYP11A1, CYP17A1) were significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Surprisingly, PS was detected in the testicular tissue in both PS and PS+PFOS groups. Our findings highlight an underappreciated risk of inhaling trace emerging pollutants mixtures on male fertility. - Source: PubMed
Publication date: 2026/04/23
Zhao LuweiChen YuweiPang GuanhuaLi YifeiHu RuokunXiao YuxinHe Miao - - Source: PubMed
Publication date: 2026/03/31
Saluja PrachiAtaya AliKircher KristenDiaz BriannaHelman DonaldGomez Rojas Olga RRuoss StephenWang Bonnie RKazerooni EllaGupta Nishant - Severe dengue is influenced by the virus serotype, viral load, host exposure status, immune response, host genetics, and other host factors. The objective of the present study was to identify a panel of prognostic markers for severe dengue during the viraemic phase. We investigated 326 real-time RT-PCR positive dengue cases to find out the association of viral load, antibody titers, and immune status. Plasma levels of 27 cytokines, chemokines, and endothelial cell-related factors were estimated in a subset of 206 patients. Viral load was lower in DENV-3 cases compared to DENV-1 and DENV-2 cases (p < 0.0001). Viral load was lower in secondary infections compared to primary infections, irrespective of serotypes (p < 0.0001). Viral load was not different between dengue patients without warning signs (DWOWS), dengue with warning signs (DWWS), and severe dengue. The total number of cytokines, chemokines, and growth factors produced above the assay detection threshold was higher in severe cases compared to DWOWS and DWWS (p < 0.05). Penalized multivariate regression identified significant associations between dengue serotype and IgM OD ratio, viral load (log₁₀), granulocyte colony-stimulating factor, interferon (IFN)-γ induced protein-10 (IP-10), and macrophage inflammatory protein-1β (MIP-1β) (p < 0.05), with good discrimination between DENV-1 and DENV-2 infections (area under the curve [AUC] = 81.11%). IgA OD ratio, viral load (log₁₀), interleukin-10 (IL-10), MIP-1α, syndecan-1 (SDC-1), and vascular endothelial growth factor-A were significantly associated with immune status, accurately distinguishing primary and secondary infections (AUC = 92.56%). IFN-γ, IL-1β, IL-1RA, IL-2, IL-6, IL-8, IL-10, IL-18, and TPO were significantly elevated in severe dengue cases compared to DWOWS and DWWS (p < 0.05). Exploratory penalized regression results suggested higher odds of the dengue severity with increasing levels of IgA, IgE, G-CSF, GM-CSF, IFN-α, IFN-γ, IL-1β, IL-1RA, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IP-10, MCP-1, resistin, SDC-1, TNF-α, and VEGF-D (OR > 1 per standard deviation increase). To conclude, the present study suggests that a dysregulated immune response, indicated by elevated levels of cytokines, chemokines, and endothelial cell-related factors, occurs in the viraemic phase of severe dengue cases and can be exploited to design a panel of prognostic markers. - Source: PubMed
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