Ask about this productRelated genes to: BMP4 protein
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
Related products to: BMP4 protein
Related articles to: BMP4 protein
- As a widely distributed hazardous substance in agriculture and food, arsenic has become a global public health concern. Riboflavin is known for its anti-inflammatory and antioxidant properties, but whether it mitigates arsenic-induced male reproductive damage remains unclear. To clarify arsenic's reproductive toxicity, network toxicology was first used to identify potential targets. Subsequently, thirty-six 4-week-old male mice were administered arsenic trioxide (5 mg/L in drinking water) and/or riboflavin (10 mg/kg in diet) for 22 weeks to establish a riboflavin intervention model. Network toxicology identified that arsenic induces male infertility via multiple signaling pathways, such as the TGF-β signaling pathway. In vivo, arsenic diminished sperm quality, caused histopathological damage, and impaired both blood-testis barrier integrity and Sertoli cell proliferation, while riboflavin effectively mitigated these detrimental effects. In vitro, TM4 cell experiments further confirmed that riboflavin reversed arsenic-induced decline in cell viability and cytoskeletal damage. This study is the first to demonstrate that the protective effect of riboflavin is mainly attributed to its ability to mediate the binding of Bmp4 to Bmpr1α, thereby reversing arsenic-induced toxicity, providing a new perspective for exploring riboflavin's role in alleviating arsenic toxicity. - Source: PubMed
Publication date: 2026/09/16
Zhou YunxiaoLu YiguangXiang QingSong XiaochaoYang WeiZhao YangfeiLiang ChenBai JianCheng MengyuZhang Jianhai - The offspring has different responses to maternal prenatal stress, some susceptible ones exhibit depression or anxiety-like behavior, and some ones demonstrate resilience and do not go on to develop behavior disorders. However, the mechanism underlying the resilience in the offspring to maternal prenatal stress remains unclear. In this study, we aimed to explore whether BMP4 signaling was associated with resilience to depression in the offspring following maternal prenatal stress, and further to explore whether inhibition of BMP4 signaling could promote resilience to depression in the offspring. The pregnant rats were performed mild restraint stress model. After delivery, sucrose preference test, open field test and forced swimming test were used to assess susceptibility or resilience in the offspring. BMP4 inhibitor noggin was administrated to inhibit BMP4 signaling. Hippocampal BMP4- phospho-Smad1/5/8-Id2 signaling and noggin level were measured by RT-PCR and Western Blot Analysis. Immunohistochemistry was used to measure the hippocampal neurogenesis. We found that hippocampal BMP4, phospho-Smad1/5/8 and Id2 level in susceptible offspring rats were significantly higher than that in resilience group. There was less number of BrdU/NeuN positive cells in the dentate gyrus of the hippocampus in susceptible offspring rats than that in resilience group. Administration of BMP4 inhibitor noggin to the pregnant rats suffering from restraint stress could result in an increase of the resilient offspring rats from 16.67% (5/30) to 56.67% (17/30). These observations indicate that BMP4 signaling may be a potential target for promoting resilience to depression for the offspring from maternal prenatal stress. - Source: PubMed
Publication date: 2026/09/28
Chen MiaomiaoLiang RuobingZhu QiaomianYang YangHan YangWang JieZhang Huiping - Perivascular adipose tissue (PVAT) has emerged as a central regulator of vascular homeostasis in large arteries, with its dysfunction driving the pathogenesis of atherosclerosis, hypertension, and metabolic diseases. In the past, our understanding of PVAT was limited by bulk omics approaches that obscured the tissue's profound spatial, cellular, and functional heterogeneity. Here, we review how multimodal single-cell technologies, including single-cell RNA sequencing, spatial transcriptomics, and AI integration, are now decoding the PVAT ecosystem with unprecedented resolution. These approaches have generated an integrated atlas that reveals depot-specific cellular architectures, dynamic phenotypic plasticity, and spatially organized crosstalk between biological circuits that drive vasculopathy. We highlight novel biomarkers and actionable therapies emerging from these insights, such as preadipocytes and BMP4-induced browning. Finally, we propose a translational roadmap that prioritizes human PVAT biobanking, CRISPR-based lineage tracing, and AI-driven modeling to transform these mechanistic discoveries into precision interventions. Ultimately, by establishing PVAT as a central orchestrator of vascular homeostasis, these single-cell insights provide the mechanistic foundation to therapeutically intercept cardiometabolic disease at its cellular source. - Source: PubMed
Publication date: 2026/09/11
Xu YujunBersi Matthew R - Early postnatal heart growth requires a transition from cardiomyocyte proliferation to enlargement and binucleation. Using morphometric, transcriptomic, signaling, and single-cell analyses in neonatal mice, we show that this transition occurs predominantly between postnatal day 3.5 and 4.5 (P3.5-P4.5), accompanied by declining β-catenin abundance and increased SMAD1/5/9 phosphorylation. Pharmacological disruption of β-catenin/CBP signaling or Ctnnb1 knockdown promotes cardiomyocyte enlargement, whereas β-catenin stabilization by CHIR-99021 enhances cell-cycle activity and estimated ventricular cardiomyocyte number while limiting enlargement. Transcriptomic analysis reveals a Sox2/Zic1/Olig2 module enriched in early neural/glial cells, suggesting the onset of postnatal cardiac nervous system development. Wnt pathway components are active in endothelial, mesenchymal, and neural populations during the early postnatal window, whereas BMP signaling peaks in cardiomyocytes at P6. These findings reveal a multi-lineage interplay between Wnt and BMP signaling that balances cardiomyocyte number expansion versus enlargement during early postnatal heart development. - Source: PubMed
Publication date: 2026/09/24
An HuiHu HaoChen SaijingChen TingtingHu YafeiYu TongtongWang AnlanJin ShengweiLi Ming - Extraembryonic lineages, specifically the trophectoderm (TE) and primitive endoderm (PrE), are indispensable for early embryogenesis and successful pregnancy. Expanded potential stem cells (EPSCs) can contribute to both embryonic and extraembryonic fates, providing a platform to model early lineage specification. - Source: PubMed
Publication date: 2026/09/09
Kim HaneulCai LianHyun Sang-HwanKim Eunhye