Ask about this productRelated genes to: BMP2 protein
- Gene:
- BMP2 NIH gene
- Name:
- bone morphogenetic protein 2
- Previous symbol:
- BMP2A
- Synonyms:
- -
- Chromosome:
- 20p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
Related products to: BMP2 protein
Related articles to: BMP2 protein
- Chronic rhinosinusitis (CRS) comprises distinct phenotypes with divergent inflammatory and tissue remodeling patterns. Bone morphogenetic proteins (BMPs) are key regulators of airway repair; however, it remains unclear whether phenotypic differences between CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) are associated with BMP ligand abundance or downstream pathway activity. We investigated phenotype-specific BMP/Smad pathway patterns and their potential relevance to airway remodeling. - Source: PubMed
Publication date: 2026/04/22
Eyibilen AhmetHira Serdar - The early gonads of mammals contain primordial germ cells (PGCs) and gonadal somatic cells. In females, the gonadal somatic cells promote the specification of PGCs into oogonia and their entry into meiosis, which is crucial for oogenesis. Although single-cell transcriptome sequencing technology holds significant advantages in cell type identification, its inability to resolve spatial positional information substantially hampers research on communication mechanisms between germ cells and adjacent somatic cells. Here, we utilized high-resolution spatial transcriptomic technology to dissect the spatial dynamics of various cell types during the specification of PGCs into oogonia and their entry into meiosis in porcine gonads. We clarified the spatial localization of two waves of granulosa cells in the supporting cell lineage and their roles in regulating germ cell development. Furthermore, we found that interstitial and endothelial cells were predominantly located in the medullary region of the early gonads. Notably, cell-cell communication analysis revealed the critical role of BMP signaling (BMP2, BMP4 and GDF5) in driving the specification of PGCs into oogonia and their subsequent entry into meiosis. Our study provides a spatially resolved understanding of the PGC-to-oogonia specification in vivo and offers critical resources for reconstituting oogenesis in vitro. - Source: PubMed
Publication date: 2026/03/30
He PengchengXia WenzheChen TianzhiYan YaxuanGao DengfengTeng YadiZhao TingChen XinzeFeng ZhiqiangLi RunboWang MengKe YuwenHan Jianyong - Osteokines, primarily secreted by bone, have been implicated in brain function and Parkinson's disease (PD) pathogenesis, yet their circulating levels in PD and potential role in the relationship between bone mineral density (BMD) and PD remain unclear. 80 participants (40 PD patients and 40 controls) were enrolled to measure plasma levels of eight osteokines (GPNMB, OPN, SOST, DKK1, RANKL, FGF23, BMP2, and BMP4) and assess their associations with clinical scales. Mendelian randomization (MR), SMR, and colocalization analyses were performed to evaluate causal relationships between osteokines and PD. Restricted cubic spline (RCS) models were applied to explore nonlinear associations between BMD, osteokines, and PD. GPNMB levels were significantly elevated in PD patients and showed a linear association with PD risk. Higher GPNMB levels were associated with worse cognitive performance and clinical severity, while higher SOST levels correlated with milder symptoms. Genetic analyses consistently supported a causal and colocalized relationship between GPNMB and PD. Total coxa BMD and T-score were lower in PD, but not statistically significant. RCS analysis revealed an "n-shaped" association between total coxa T-score and both PD and GPNMB levels. Overall, GPNMB appears causally linked to PD risk and may mediate the bone-brain axis connecting BMD with PD susceptibility. - Source: PubMed
Publication date: 2026/03/18
Guo XingzhiWei PeiyaoShi WenzhiZhou RongLi Rui - Coronary artery calcification (CAC), a hallmark of coronary atherosclerosis, links closely to dysregulated lipid metabolism and chronic inflammation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors exert potent lipid-lowering and anti-inflammatory effects, holding translational potential for vascular calcification intervention. However, evidence on PCSK9 inhibition's impact on vascular calcification remains inconsistent. Here, we combined genetic causal analysis with / experiments to explore the therapeutic efficacy of PCSK9 inhibition against CAC and the mediating role of fibroblast growth factor 23 (FGF23) in this process. - Source: PubMed
Publication date: 2026/02/16
Wang WeijianYe JiangpingHu XinyiChen ZongzhengWang LiChen Liang - This study aimed to determine the optimal dietary zinc (Zn) requirement for meat ducks during days (d) 22-42. A total of 336 ducks were assigned to 1 of 6 dietary treatments supplemented with 0, 20, 40, 60, 80, or 100 mg/kg Zn in the form of ZnSO·7HO. Results showed that final body weight (FBW), average daily gain (ADG), and average daily feed intake (ADFI) increased linearly with increasing dietary Zn levels (P<0.05), while the Zn concentrations of the serum, tibia, liver, pancreas increased linearly and quadratically (P < 0.05). Dietary supplementation of 40-60 mg Zn/kg enhanced copper-zinc superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-PX) activities (P < 0.05) and reduced the malondialdehyde (MDA) content in serum (P<0.05). Supplementation with 80-100 mg Zn/kg improved tibial ash content and tibial density (P<0.05). Furthermore, supplementation of 100 mg Zn/kg improved feather quality and follicle development by upregulating TAK1, Smad2, and BMP2 mRNA expression and downregulating BMP4 mRNA expression (P < 0.05). Based on regression analysis, the optimal dietary Zn requirement was estimated to be 71.7-104.1 mg/kg when using a basal diet containing 25.5 mg Zn/kg. Furthermore, the dietary Zn requirement for improving bone and feather quality was higher than that for supporting growth. - Source: PubMed
Publication date: 2026/01/12
Lu ZhijunCao QingjiZhu KaixuanQu ShicaiChang YueDing XuanLiu JiaqiSun GuangjieJiang XintingZhang HuaqiZhu Yongwen