Ask about this productRelated genes to: EBI3 protein
- Gene:
- EBI3 NIH gene
- Name:
- Epstein-Barr virus induced 3
- Previous symbol:
- -
- Synonyms:
- IL27B, IL35B
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2018-09-13
Related products to: EBI3 protein
Related articles to: EBI3 protein
- Cytokines of the interleukin 12 (IL-12) family are secreted by cells of the innate immune system to regulate adaptive immune responses. IL-12 family cytokines are heterodimers composed of an α- and a β-subunit each, with subunits shared between the different family members. It is increasingly becoming clear that, in addition to the family-characteristic heterodimers, the α/β subunits often engage in further pairings and can also regulate immune responses in isolation. Here, we review our current understanding of IL-12β/p40 and EBI3, the two β-subunits within the family. IL-12β/p40 and EBI3 are emerging as critical regulators of immunity in health and disease. They function by forming heterodimeric assemblies but also as monomers and homodimers. Due to this complexity, many open questions remain concerning their molecular structure and assemblies, their receptors and their detailed mode of action. It will be key to address these to seize the therapeutic opportunities of IL-12β/p40 and EBI3 despite their structural and functional complexity. - Source: PubMed
Publication date: 2026/04/07
Menon Priyanka RajeevLesniowski FlorianFeige Matthias J - Humans and mice display elevated levels of IL-27, an immunosuppressive cytokine shown to increase during neonatal bacterial sepsis and compromise survival. This study explores two hypotheses for regulation of IL-27 expression: 1) decreased DNA methylation in newborns that contributes to increased expression of IL-27 genes; 2) neonatal hormones regulate IL-27 expression through upstream hormone response elements (HREs). - Source: PubMed
Publication date: 2026/03/26
Vance Jordan KWang LeiPovroznik Jessica MBusada Jonathan THu GangqingRobinson Cory M - - Source: PubMed
Publication date: 2026/03/28
Liang LinLiu SiyiLi YanlingZeng FengHe QianWang ZhenxinDeng JunZhou Yanhong - IL-10, TGF-β, IL-4, IL-27, and EBI3 are cytokines that regulate inflammation, tissue repair, and fibrosis in the kidney and other organs. These cytokines may contribute to different aspects of chronic kidney disease (CKD), end-stage renal disease (ESRD), and systemic lupus erythematosus (SLE), which are associated with renal dysfunction and aberrant immune regulation. This study investigates the role of these cytokines in patients with concurrent kidney disease and SLE to understand their contribution to the pathogenesis and progression of this complex condition. - Source: PubMed
Publication date: 2026/02/19
Bayati PariaNeamah Doaa HusseinBagheri YasserSadani SomayehEmtiazi NikooSaeidi MohsenGhorbani SomayehAmirkhanlou Saeid - Preeclampsia (PE) complicates 2-8% of pregnancies and involves placental hypoxia and HIF-pathway activation, especially in early-onset PE (eoPE). Chemical mimetics like cobalt (II) chloride (CoCl) and oxyquinoline derivatives model trophoblast hypoxia in vitro, yet their fidelity in recapitulating PE gene profiles remains unclear. Integrating patient tissue analyses with experimental models may reveal common markers and validate physiologically relevant paradigms. - Source: PubMed
Publication date: 2026/02/07
Knyazev EvgenyKulagin TimurAntipenko IvanTonevitsky Alexander