Ask about this productRelated genes to: EBI3 protein
- Gene:
- EBI3 NIH gene
- Name:
- Epstein-Barr virus induced 3
- Previous symbol:
- -
- Synonyms:
- IL27B, IL35B
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2018-09-13
Related products to: EBI3 protein
Related articles to: EBI3 protein
- There are relatively well-substantiated concepts regarding the differences in the clinical course of metastatic colorectal cancer depending on the primary tumor localization: right- and left-sided (including rectal). However, many clinical trials demonstrate clear differences in the selected efficacy of adjuvant chemotherapy in the treatment of rectal versus colon cancer. We hypothesize that there are significant differences in long-term outcomes between patients with metastatic rectal cancer (RC) and those with left-sided colon cancer (LSCC) that may depend on the genetic profile of the primary tumor. - Source: PubMed
Publication date: 2026/04/15
Semenov N NZhukova L GYakovlev V A - Cytokines of the interleukin 12 (IL-12) family are secreted by cells of the innate immune system to regulate adaptive immune responses. IL-12 family cytokines are heterodimers composed of an α- and a β-subunit each, with subunits shared between the different family members. It is increasingly becoming clear that, in addition to the family-characteristic heterodimers, the α/β subunits often engage in further pairings and can also regulate immune responses in isolation. Here, we review our current understanding of IL-12β/p40 and EBI3, the two β-subunits within the family. IL-12β/p40 and EBI3 are emerging as critical regulators of immunity in health and disease. They function by forming heterodimeric assemblies but also as monomers and homodimers. Due to this complexity, many open questions remain concerning their molecular structure and assemblies, their receptors and their detailed mode of action. It will be key to address these to seize the therapeutic opportunities of IL-12β/p40 and EBI3 despite their structural and functional complexity. - Source: PubMed
Publication date: 2026/04/07
Menon Priyanka RajeevLesniowski FlorianFeige Matthias J - Humans and mice display elevated levels of IL-27, an immunosuppressive cytokine shown to increase during neonatal bacterial sepsis and compromise survival. This study explores two hypotheses for regulation of IL-27 expression: 1) decreased DNA methylation in newborns that contributes to increased expression of IL-27 genes; 2) neonatal hormones regulate IL-27 expression through upstream hormone response elements (HREs). - Source: PubMed
Publication date: 2026/03/26
Vance Jordan KWang LeiPovroznik Jessica MBusada Jonathan THu GangqingRobinson Cory M - Chemotherapy is one of the important means to improve the 5-year survival rate of nasopharyngeal carcinoma (NPC) patients, and commonly used chemotherapy drugs include cisplatin and gemcitabine. Previous studies have shown that chemotherapy can induce some tumor cells to exhibit a senescent phenotype, thereby altering the tumor microenvironment towards tumor immune suppression and tumor recurrence. However, the role and detailed mechanism of chemotherapy in the senescence of NPC cells are not yet clear, and further in-depth research is needed. This study focuses on the mechanism of cisplatin-induced cellular senescence, a major form of chemotherapy-induced senescence, in the progression of NPC. Our study found that cisplatin induces tumor cell senescence, upregulates EBI3 expression, and promotes abnormal secretion of IL-35 to mediate tumor immune escape. Specifically, senescent NPC cells release mtDNA due to mitochondrial damage, which in turn activates the cGAS-STING signaling pathway. Activation of this pathway induces the nuclear translocation of NF-κB p65, which directly binds to the EBI3 promoter and significantly upregulates EBI3 expression. Subsequently, EBI3 binds to the p35 subunit to form IL-35, which activates the JAK-STAT1 pathway of NK cells through IL-12Rβ2/GP130 receptors, inducing upregulation of the inhibitory receptor NKG2A and thereby weakening the anti-tumor function of NK cells. This study reveals for the first time a novel molecular mechanism by which cisplatin-induced senescent cells, a representative of chemotherapy-induced senescent cells, regulate NK cell anti-tumor function through the EBI3/IL-35 axis, and identifies EBI3 as a key molecular target involved in chemotherapy-induced senescence-mediated immune suppression in NPC, providing important experimental evidence for developing targeted immunotherapy strategies for NPC. - Source: PubMed
Publication date: 2026/03/28
Liang LinLiu SiyiLi YanlingZeng FengHe QianWang ZhenxinDeng JunZhou Yanhong - IL-10, TGF-β, IL-4, IL-27, and EBI3 are cytokines that regulate inflammation, tissue repair, and fibrosis in the kidney and other organs. These cytokines may contribute to different aspects of chronic kidney disease (CKD), end-stage renal disease (ESRD), and systemic lupus erythematosus (SLE), which are associated with renal dysfunction and aberrant immune regulation. This study investigates the role of these cytokines in patients with concurrent kidney disease and SLE to understand their contribution to the pathogenesis and progression of this complex condition. - Source: PubMed
Publication date: 2026/02/19
Bayati PariaNeamah Doaa HusseinBagheri YasserSadani SomayehEmtiazi NikooSaeidi MohsenGhorbani SomayehAmirkhanlou Saeid