Ask about this productRelated genes to: IL17A protein
- Gene:
- IL17A NIH gene
- Name:
- interleukin 17A
- Previous symbol:
- CTLA8, IL17
- Synonyms:
- IL-17A, IL-17
- Chromosome:
- 6p12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-10-25
- Date modifiied:
- 2019-04-23
Related products to: IL17A protein
Related articles to: IL17A protein
- Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation, bone erosion, cartilage destruction, and debilitating pain. Current therapies often fall short in preventing structural damage and restoring immune balance. To address these limitations, we evaluated MRG-001 - a fixed-dose combination of plerixafor (AMD3100) and low-dose tacrolimus (FK506) with reported immunoregulatory and regenerative potential - in preclinical models of RA. - Source: PubMed
Publication date: 2026/05/07
Zhang WeixinLopez FranciscoWan MeiZheng JunyingWesson RussellSun ZhaoliCao Xu - CD6 is an immunological synapse-associated receptor that integrates adhesive and signaling cues to shape T-cell activation. We previously showed that, in CD6-humanized mice, the anti-human CD6 monoclonal antibody UMCD6 suppresses disease severity and Th1/Th17 responses in models of autoimmunity, but its mechanisms of action in human T cells remained incompletely defined. - Source: PubMed
Publication date: 2026/08/19
Maeda KoheiCampbell Phillip LWu QiTsou Pei-SuenCooney Laura AMao-Draayer YangFox David AGurrea-Rubio Mikel - Repulsive guidance molecule-A (RGMa) is well-known for its roles in T-cell-mediated neuroinflammation and CNS repair. Innate-adaptive immune interactions, particularly between neutrophils and Th17 cells, are emerging as critical drivers of neuroinflammatory pathology in multiple sclerosis (MS). Whether RGMa regulates these neutrophil-associated Th17 responses remains largely unknown. Elucidating this mechanism may reveal novel therapeutic targets for MS. - Source: PubMed
Publication date: 2026/08/19
Zhen WeizheYang XiaoyiJiao JinsongCui LeiYu MiaoxinSun QingGao DianjiaPeng DantaoJin MingWei LaiZhang Weihe - Sleep deprivation (SD) disrupts female reproductive homeostasis, yet the mechanisms linking chronic sleep loss to premature ovarian insufficiency (POI) remain poorly defined. - Source: PubMed
Publication date: 2026/09/02
Mao JingxiaCen ChangshuangGu MengxueZhao HongLuo YongjinYao YueruDeng ZhibingGong QingquanZhang TaoChen SaiqiongHu ChunYang Yihua - Peripheral T cell profiles reflect antitumour immunity, yet systemic immune shifts often remain confounded by demographic factors. This study aimed to delineate true tumour-driven T cell alterations in lung cancer. We analysed peripheral blood from 121 lung cancer patients and strictly age- and sex-matched healthy controls using multiparametric flow cytometry, corroborated by human lung cancer spatial transcriptomics (ST). Following demographic standardisation, patients exhibited a systemic T cell priming blockade, characterised by significantly accumulated naïve T cells and depleted effector memory T cells (CD4 p < 0.01; CD8 p < 0.0001). Conversely, Th17.1 cells and immune checkpoints (e.g., PD-1, CTLA-4) were robustly elevated. Crucially, ST validated a striking intratumoural spatial accumulation of Th17.1 cells. We conclude that the peripheral expansion of Th17.1 cells is a genuine tumour-driven event that faithfully mirrors local tumour microenvironment remodelling and potential Tertiary Lymphoid Structure (TLS) neogenesis. This positions peripheral Th17.1 profiling as a valuable, noninvasive biomarker for evaluating systemic immunosuppression and guiding personalised immunotherapy. - Source: PubMed
Publication date: 2026/09/01
Lv JiaoyunYin WenchengNie XialinChen SiyuanZhong YuqiYang ShufaHe ZiyiYao YanhongWang QiqiZhao YangDai Hui