Ask about this productRelated genes to: FGF1 protein
- Gene:
- FGF1 NIH gene
- Name:
- fibroblast growth factor 1
- Previous symbol:
- FGFA
- Synonyms:
- AFGF, ECGF, ECGFA, ECGFB, HBGF1, ECGF-beta, FGF-alpha, GLIO703
- Chromosome:
- 5q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- FGF12 NIH gene
- Name:
- fibroblast growth factor 12
- Previous symbol:
- FGF12B
- Synonyms:
- FHF1
- Chromosome:
- 3q28-q29
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2018-02-13
Related products to: FGF1 protein
Related articles to: FGF1 protein
- Desmoplasia, a dense fibrotic reaction, is a hallmark of pancreatic ductal adenocarcinoma (PDAC) and fuels chemoresistance through multiple mechanisms. Here, we evaluated heparanase (HPSE), an endoglycosidase that remodels extracellular matrix (ECM) and drives fibrogenesis, as a potential target in PDAC. Immunohistochemical analysis of human PDAC tissues showed elevated HPSE expression, along with increased levels of fibroblast growth factors 1 and 2 (FGF1/2), reflecting their liberation by HPSE-catalyzed heparan sulfate cleavage. High expression of all three proteins was associated with worse overall and disease-free survival. In vitro coculture assays showed that the HPSE inhibitor PI-88 suppressed PDAC cell-induced activation of pancreatic stellate cells (PSCs) and prevented ECM stiffening without inducing cytotoxicity. Mechanistically, tumor-derived HPSE activated ERK signaling and promoted FGF1/2 production in PSCs, both of which were effectively suppressed by PI-88. In orthotopic mouse models, gemcitabine treatment upregulated HPSE and FGF1/2, whereas gemcitabine-resistant tumors exhibited further increases in these factors, accompanied by enhanced PSC activation and collagen deposition. Importantly, triple therapy with PI-88, gemcitabine, and Abraxane significantly suppressed tumor growth and prolonged survival relative to all mono- and doublet regimens. Immune profiling revealed that this combination reduced PSC activation, contracted M2 macrophage and regulatory T cell populations, and expanded M1 macrophages, CD8⁺ T cells, and NK cells. In conclusion, these data underscore HPSE as a key driver of fibrosis and chemoresistance in PDAC and support HPSE inhibition as a promising strategy to enhance therapeutic efficacy. - Source: PubMed
Publication date: 2026/05/08
Chen Chang-JungWang Hao-ChenHuang Wen-YenChang Stanley Shi-ChungChang AlarngLin Chieh-LiangYang Chih-YaShan Yan-Shen - After hind limb amputation in lizards, scars or short outgrowths are formed. FGFs may stimulate regeneration. Injections of FGF-1/-2 into the limb stump were made until 26 days post-amputation. This treatment gives rise to outgrowths of 1.5-3.5 mm within 40-70 days post-amputation, containing axial cartilages continuous with stump bones but missing muscles. Immunohistochemical localization in the outgrowth shows 5BrdU-labeled proliferating cells in the apical wound epidermis and perichondrium at 40-50 days post-amputation. Low to no proliferation is present in the axial cartilages and connective tissues at 60 and 70 days when growth terminates, except in scales. Immunodetection of FGF8 and Shh shows that the proteins are present at 30-40 days in the wound epidermis, apical connective tissue and perichondrium. These proteins lower to disappear in outgrowths from 50 to 70 days post-amputation, coincident with lowering of cell proliferation. The study suggests that the injection of FGF1/2 initially stimulates the growth of the limb mainly in cartilaginous axial structures, dense connective tissue, and new scales. No stimulation of muscle tissues is observed. Short cartilaginous rods of tibia, fibula or femur are produced but no autopodial elements. The presence of FGF8 and Shh in the wound epidermis and perichondrium of the initial outgrowths and their subsequent downfall reflect the initial growth and the later growth cessation. In future experiments, longer treatments with FGFs, hyaluronate and other signaling proteins, micro-injected in specific regions of the outgrowths may further enhance limb growth in this or other amniote models of limb regeneration. - Source: PubMed
Publication date: 2026/03/18
Alibardi Lorenzo - To investigate the parent-of-origin effects (POE), interactions between imprinted and non-imprinted genes, and POE-environment interactions of candidate genes in the FGF/FGFR signaling pathway on the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). A case-parent trio design was adopted, including 806 NSCL/P trios (2 418 individuals). Single-locus POE was estimated using log-linear models; interactions between imprinted and non-imprinted genes were analyzed using the Cordell method; and POE-environment interactions were assessed via the test. Bonferroni correction was applied for multiple testing. A total of 379 single-nucleotide polymorphisms (SNPs) located on two imprinted genes ( and ) and 17 non-imprinted genes within the FGF/FGFR signaling pathway were included in the NSCL/P trio analysis. Single-locus POE analysis identified 23 SNPs in , , , , and with potential POE (all <0.05). However, none remained statistically significant after Bonferroni correction (all >1.32×10⁴). Interaction analysis of the 23 SNPs with potential POE revealed positive signals between 9 SNP pairs from the imprinted gene and the non-imprinted gene , and 1 SNP pair from and (all <0.05). The interaction between rs9518631 and rs10510097 remained statistically significant after Bonferroni correction (=1.97×10³). POE-environment interaction analysis indicated that the POE of 5 SNPs located on , , and were influenced by maternal passive smoking during pregnancy, and the POE of rs10510097 was influenced by maternal multivitamin supplementation during pregnancy (all <0.05). However, none of these findings remained statistically significant after Bonferroni correction (all >2.17×10³). The FGF/FGFR signaling pathway may influence the risk of NSCL/P through interactions between the imprinted gene and the non-imprinted gene . - Source: PubMed
Hou T JWang M YPeng H XGuo H DLi Y XZhang H YYe X YLuo L RZhu H PWu T - The initiation of fibroblast growth factor 1 (FGF1) expression coincident with the decrease of FGF2 expression is a well-documented event in prostate cancer (PCa) progression. Lactate dehydrogenase A (LDHA) and LDHB are essential metabolic products that promote tumor growth. However, the relationship between FGF1/FGF2 and LDHA/B-mediated glycolysis in PCa progression is not reported. Thus, we aimed to explore whether FGF1/2 could regulate LDHA and LDHB to promote glycolysis and explored the involved signaling pathway in PCa progression. - Source: PubMed
Publication date: 2024/05/19
Ye YongkangYang FukanGu ZhanhaoLi WenxuanYuan YinjiaoLiu ShaoqianZhou LeHan BoZheng RuinianCao Zhengguo - Heterosis refers to the phenomenon where hybrids exhibit superior performance compared to the parental phenotypes and has been widely utilized in crossbreeding programs for animals and crops, yet the molecular mechanisms underlying this phenomenon remain enigmatic. A better understanding of the gene expression patterns in post-hatch chickens is very important for exploring the genetic basis underlying economically important traits in the crossbreeding of chickens. In this study, breast muscle and liver tissues ( = 36) from full-sib F1 birds and their parental pure lines were selected to identify gene expression patterns and differentially expressed genes (DEGs) at 28 days of age by strand-specific RNA sequencing (ssRNA-seq). This study indicates that additivity is the predominant gene expression pattern in the F1 chicken post-hatch breast muscle (80.6% genes with additivity) and liver (94.2% genes with additivity). In breast muscle, Gene Ontology (GO) enrichment analysis revealed that a total of 11 biological process (BP) terms closely associated with growth and development were annotated in the identified DEG sets and non-additive gene sets, including , , , , , , , , , and . Kyoto Encyclopedia of Genes and Genomes (KEGG) annotation presented that a total of six growth- and development-related pathways were identified, involving key genes such as , , , , and , including the PPAR signaling pathway, TGF-beta signaling pathway, and mTOR signaling pathway. Our results may provide a theoretical basis for crossbreeding in domestic animals. - Source: PubMed
Publication date: 2024/04/29
Zhao JianfeiChen MeiyingLuo ZhengweiCui PengxinRen PengWang Ye