Ask about this productRelated genes to: CD351 antibody
- Gene:
- FCAMR NIH gene
- Name:
- Fc fragment of IgA and IgM receptor
- Previous symbol:
- -
- Synonyms:
- FKSG87, FCA/MR, CD351
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-03
- Date modifiied:
- 2016-01-21
Related products to: CD351 antibody
Related articles to: CD351 antibody
- Genetically engineering human pluripotent stem cell (hPSC)-derived islets is a promising strategy for improving transplantation for diabetes cell therapy; however, genetic perturbations that modulate transplantation outcomes have yet to be systematically explored. - Source: PubMed
Maestas Marlie MBradley KameronShunkarova MiraMukherjee NoyonikaIshahak MatthewLu JamesMillman Jeffrey R - Allelic variation in chicken red blood cell alloantigens has multiple associations with production traits or disease resistance. Recent studies have identified the gene and chromosomal location for chicken alloantigen genes A, D, E, I, and L. Haplotypes (specific SNP combinations) within each gene were identified to distinguish the serological variants found within the different blood systems. The objective of this study was to characterize alloantigen alleles in Line UCD-001, an inbred line of Jungle fowl, which is the original reference sequence for the chicken genome. The B blood group, the chicken MHC, was the only alloantigen system having known serological and SNP types, with UCD-001 typing as serological B and DNA-based BSNP-A09A. Genome sequence and DNA samples from the original UCD-001 reference bird, plus an additional 10 UCD-001 birds, were used to identify five additional alloantigen system alleles within UCD-001. The alloantigen genes and their SNP types for the A and the linked E systems are complement component 4 binding protein, membrane, C4BPM-H12, and Fc fragment of IgA and IgM receptor, FCAMR-H01, respectively. Neither of these SNP types corresponded to alleles previously characterized by serology. Alloantigen D was identified as CD99 whose SNP haplotype, CD99-H06, corresponded to the D serological allele. The I system, equivalent to the human RHCE blood group locus, was heterozygous in the reference population. Both RHCE-H01, the I serological allele, and RHCE-H06, previously unidentified by serology, were present in UCD-001. The ABCE1 gene, ATP-binding cassette subfamily E member 1, is alloantigen L with UCD-001 containing the ABCE1-H01 haplotype consistent with the L serological allele. Identifying the alloantigen genotypes of this important inbred line will facilitate studies of alloantigen effects through line crosses to produce progeny segregating for alloantigen alleles or through comparisons with other stocks. - Source: PubMed
Publication date: 2026/01/28
Taylor Robert LMcCarron Amy MFulton Janet E - Self-recognition system components including red blood cell antigens and the major histocompatibility complex (MHC) are alloantigens found on multiple cell types. Specific polyclonal antisera reactivity identified fourteen chicken erythrocyte alloantigens (A, B, C, D, E, H, I, J, K, L, M, N, P, R). Multiple associations between alloantigen variation and disease or production traits have been reported. Blood group B, the MHC, was the first system whose genes and function were classified. Recent investigations sought to identify genes and chromosomal locations for other alloantigen systems. Phenotype-pooled DNA from pedigree and non-pedigree chickens having known alloantigen types underwent genome-wide association (GWAS) analyses using data from either 600K or 54K SNP panels. DNA from independent samples was used to confirm candidate gene associations. Genome sequences from elite production and experimental lines with identified alloantigen alleles were examined. Candidate genes within strong GWAS peaks were bioinformatically screened for cell surface expression and co-segregation of non-synonymous SNP with serologically defined haplotypes. Specific genes have now been identified for four alloantigen systems. Linked genes found on chromosome 26 are A = complement component 4 binding protein, membrane (C4BPM) and E = Fc fragment of IgA and IgM receptor (FCAMR). The D system gene (CD99) is on chromosome 1. Alloantigen I, equivalent to the human Rh blood group locus (RHCE), lies on chromosome 23 including deletions covering > 6,000 bp predicted to affect the last seven RHCE gene exons. Candidate regions were found for alloantigens L, H, and M on chromosomes 4, 24, and 26, respectively. Small sample size hindered definitive gene identification. In summary, four alloantigen genes with allele associated variants have been identified. Genes C4BPM, CD99, FCAMR, and RHCE play roles in processes such as complement regulation and immune cell migration. Chromosomal locations have been defined for three other alloantigen systems. Identification of specific genes responsible for the blood system alleles provides tools to study these chicken alloantigens for relationships with disease and production traits. - Source: PubMed
Publication date: 2025/10/24
Taylor Robert LFulton Janet E - Pigs are important agricultural animals and valuable biomedical models. The intestinal tract is a crucial digestive organ and the largest immune organ. However, the function of pig intestines at single-cell resolution remains poorly understood. Here, we created single-nucleus transcriptomic maps of the ileum and cecum for wild boars, Bama Xiang pigs, and Large White pigs, aged 30, 42, 150, and 730 d. Our atlas revealed 19 major cell types and 58 cellular subtypes, including several previously uncharacterized cellular subtypes, such as EBF1 fibroblasts, TMEM163 macrophages, and neuron subtypes expressing FCAMR. We discovered and confirmed that ileum neurons, rather than cecum neurons, can regulate inflammatory responses, highlighting interactions of neurons with dendritic cells (DCs) and lymphatic endothelial cells (LECs) through the NAMPT-INSR ligand-receptor pair in the ileum. Microbial-derived short-chain fatty acids, such as propionic acid and acetic acid, enhanced plasma cell differentiation and humoral immune responses by upregulating XBP1 and SDC1 expression, thereby endowing wild boars with a stronger immune response than domestic pigs. We identified and validated the enterocyte-enriched transcription factors FOXO1 and NR1H4 in wild boars, which contributed to the superior nutrient absorption of wild boars relative to domestic pigs. Furthermore, we comprehensively characterized the postnatal development of wild boar intestinal cells and revealed that plasma cells presented the most pronounced developmental changes. We identified highly conserved cell types and features between pig and human intestines. Overall, our work provides a foundation for improving pig feed conversion and health while also providing a reference for research on human intestinal diseases. - Source: PubMed
Publication date: 2025/09/10
Xiao YanyuanZou XiaoxiaoYang BinHuang Lusheng - Coccidiosis, a major poultry protozoal disease caused by several Eimeria species, compromises gut health causing significant losses. This study assessed the association of haplotypes of the major histocompatibility complex (MHC) and other blood alloantigens found in commercial egg production chickens with resistance to coccidiosis. Pedigreed White Leghorn offspring segregating for the MHC-B region, plus four additional alloantigen systems A (C4BPM), D (CD99), E (FCAMR), and I (RHCE) were tested for differential resistance to coccidiosis in five 26-day (d) trials (n= 235 birds in total). On d 19, all birds were inoculated with a cocktail of E. acervulina, E. maxima, and E. tenella oocysts and allocated to individual cages. Phenotypes evaluated included body weight gain (BWG), feed intake (FI), feed conversion ratio (FCR), gross and microscopic lesion scores (GLS and MLS), and oocyst shedding (oocysts per gram, OPG). Haplotypes of the five blood systems were determined by SNP genotyping. A positive and negative association means an increase and decrease in a phenotypic trait, respectively, with each additional copy (0, 1 or 2) of a given haplotype. Results were considered statistically significant at P ≤ 0.05. The CD99-H01 haplotype association was positive with BWG but negative with FCR. Genotype B21B21 had the highest GLS in the jejunum establishing a positive association between MHC B21 and jejunal GLS. Further, the B12B15 genotype had a lower E. maxima OPG compared with the B12B21 genotype. The I system I-H01 haplotype had a negative association with jejunal and cecal GLS. Duodenal GLS was lower in E-H02/H02 compared to the E-H07/H07 genotype of the E system. Haplotypes B21, blood systems D-H01, E-H02, and I-H01 were associated with improved resistance to coccidiosis. The association of specific haplotypes of the MHC-B and other alloantigen systems D, E, and I with resistance and susceptibility traits during mixed Eimeria infection underscores the need for further investigations of these haplotypes' effects on coccidiosis resistance in commercial lines, validating the inclusion of different blood systems in selection programs. - Source: PubMed
Publication date: 2025/04/17
Niraula AbhisekWolc AnnaFulton Janet ETaylor Robert LDalloul Rami A