Ask about this productRelated genes to: LDH2 protein
- Gene:
- ALDH1A2 NIH gene
- Name:
- aldehyde dehydrogenase 1 family member A2
- Previous symbol:
- -
- Synonyms:
- RALDH2
- Chromosome:
- 15q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-30
- Date modifiied:
- 2018-05-03
Related products to: LDH2 protein
Related articles to: LDH2 protein
- Analysis of runs of homozygosity (ROH) in commercial breed genomes is important for accurately assessing the population inbreeding status and exploring homozygous regions related to economic traits formed by selection pressure. The Danish Large White (LW) pig is a commercially important breed renowned for its superior growth efficiency and reproductive performance. In the present study, we identified ROH segments of Danish LW pigs based on 43 individual whole-genome resequencing data. We then calculated the inbreeding coefficient and screened candidate genes with important economic traits from the ROH islands. A total of 9446 ROH segments were identified in the LW pig population. Each LW pig carried 219.67 ROH. Most ROH were , and the average genomic inbreeding coefficient ( ) in LW pigs was 0.24. However, the proportion of ROH ( ) in LW pigs has reached 10 %, indicating selection pressure or inbreeding in recent times. Candidate genes related to reproductive traits (, , , , , , and ), and growth and development traits (, , , , , , , , , , and ) were identified in the genomic ROH islands of LW pigs. In conclusion, the present study provides further assessment of genetic diversity and inbreeding in the Danish LW pig population. In addition, our results provide useful insights into the functions of ROH on a hereditary basis and the role that ROH play in controlling the excellent characteristics of Danish LW pigs. - Source: PubMed
Publication date: 2026/01/12
Ding WeiminWu XudongBu YuZhang WeiWang YuanlangDing YueyunZheng XianruiZhang XiaodongYin Zongjun - The developing embryo harbors multiple hematopoietic programs, categorized as either intra-embryonic or extra-embryonic yolk-sac, that differ in their spatio-temporal origins and developmental potential. In the vertebrate embryo, the hematopoietic stem cell (HSC) derives from the definitive intra-embryonic hematopoietic program and is dependent on stage-specific retinoic acid (RA) signaling. We have recently modelled aspects of this developmental process in vitro using human pluripotent stem cells (hPSCs) and identified a KDR+CXCR4+ mesodermal population that generates definitive hematopoietic progeny in a uniquely RA-dependent manner. A subpopulation of this mesoderm expresses ALDH1A2, an enzyme involved in RA synthesis. Here, we sought to characterize the role of ALDH1A2 in the development of the human RA-dependent hematopoietic lineage and to map its mesodermal origin. Using two different engineered reporter hPSC lines, we show that specification of this lineage requires a functional ALDH1A2 enzyme at the mesoderm stage. Through functional analyses of different mesoderm subpopulations, we demonstrate that this RA-dependent lineage derives from ALDH1A2neg mesoderm by non-cell autonomous RA signaling. Collectively, these studies provide new insight into the differentiation trajectory of hPSCs towards the definitive hematopoietic lineage. - Source: PubMed
Publication date: 2026/04/08
Fernandez Nestor ADurland Lauren JGarcia AnaluciaAtkins Michael HKennedy MarionSturgeon Christopher MKeller Gordon - Sexual differentiation in amphibians involves dynamic coordination between germ cells, somatic tissues, and gene expression. However, post-metamorphic gonadal maturation and sex-specific transcriptional programs underlying it remain poorly characterized. In this study, pre-pubertal gonadal development was analyzed in Xenopus tropicalis by integrating morphological, histological, and gene expression analyses. Froglets were sampled weekly from one until 8 weeks post-metamorphosis. Morphometric and histological assessments revealed progressive gonadal maturation in both sexes. In males, testicular growth correlated with body size, whereas in females, ovarian development occurred independently of somatic parameters. Expression profiling of 12 genes showed sex-specific mRNA patterns: cyp17, amh, and amhr2 displayed a male-biased expression correlated with testicular development, while aldh1a2 and ddx4 were preferentially upregulated in females and associated with ovarian growth and follicular oocyte number. Id4 declined in females but remained stable in males, reflecting, together with ddx4 expression, distinct pregametogenesis and germline maintenance strategies. Opposite regulation of aldh1a2 and cyp26b1 supported a transient meiotic wave in females versus its basal maintenance in males. Multivariate and network analyses highlighted dmrt1, amhr2, cyp17, esr1, and ddx4 as potential nodes of sex-specific regulatory networks. These findings reveal post-metamorphic, sex-specific transcriptional programs, and provide integrated molecular and histological endpoints for studies on vertebrate sex differentiation. - Source: PubMed
Marini DanieleRoza MauricioBerg CeciliaBrouard Vanessa - The uterine endometrium is capable of scarless regeneration under coordinated estrogen and progesterone signaling across the menstrual cycle. Obesity suppresses progesterone production, leading to chronic estrogen exposure and increased endometrial hyperplasia (EH) risk. To define how obesity alters endometrial cell states, endometrial tissues from control and EH-predisposed mice fed either a control diet or a high-fat diet (HFD) were analyzed by single-cell RNA sequencing and tissue phenotyping. HFD reprogrammed endometrial stroma towards an inflammatory, pro-fibrotic state, reducing progesterone receptor-network-associated Aldh1a2 fibroblasts and expanding estrogen receptor-network-associated Gsn⁺ fibroblasts. HFD further impaired macrophage recruitment and promoted hyperplastic epithelial signatures, consistent with increased disease severity in an EH mouse model. Stromal deletion of Estrogen Receptor α established stromal estrogen signaling as a driver of HFD-induced extracellular matrix (ECM) accumulation. Collectively, these findings identify HFD-driven fibroblast reprogramming as a central mechanism linking estrogen dominance to stromal fibrosis, defective immune clearance, and heightened EH susceptibility. We propose that, in response to progesterone, fibroblast-mediated ECM remodeling is vital to normal endometrial homeostasis. - Source: PubMed
Publication date: 2026/03/24
Skalski Hilary JBennett Abigail ZWood Lauren EHarkins Shannon KArendt Amelia RLopez Espinosa Amanda GBurns Gregory WPaul Emmanuel NHostetter GalenBecker KatelynWegener MarcAdams MarieTeixeira Jose MLau KinChandler Ronald L - Compare cold adaptation mechanisms between cold-tolerant Hezuo and cold-sensitive Bama pigs. - Source: PubMed
Publication date: 2026/03/11
Li YajuanGao XiaoliZhang YatingGun Shuangbao