Ask about this productRelated genes to: CKMM protein
- Gene:
- CKM NIH gene
- Name:
- creatine kinase, M-type
- Previous symbol:
- CKMM
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-02-10
Related products to: CKMM protein
Related articles to: CKMM protein
- This study investigated variables that statistically account for a portion of the periodontitis-advanced cardiovascular-kidney-metabolic (CKM) syndrome association in cross-sectional analyses, and developed interpretable machine learning risk stratification models in individuals with periodontitis, to provide preliminary cross-sectional evidence for future hypothesis testing. - Source: PubMed
Publication date: 2026/09/10
Luo DanAn SonglinSun JingYang KunLiu HuiWang XiWang YueGao LiLiu Rui - Nephrologists support decision-making and preparation for kidney replacement therapy (KRT) and conservative kidney management (CKM). However, the frequency of nephrology review among people with chronic kidney disease (CKD) G5 has not been well characterised at the population level. - Source: PubMed
Publication date: 2026/09/10
Nakano YutaJones TimothyMcLaren RobertPlumb LucyCaskey Fergus JHole Barnaby - Low-density lipoprotein cholesterol (LDL-C) goal attainment is central to primary atherosclerotic cardiovascular disease (ASCVD) prevention, but LDL-C may not fully reflect the burden of apolipoprotein B (ApoB)-containing atherogenic particles. The prevalence and clinical correlates of residual ApoB elevation among adults who have attained PREVENT risk-stratified LDL-C goals remain unclear. - Source: PubMed
Publication date: 2026/09/09
Shi YanpingTang YuanWang MengtingZhu XuZhang Haifeng - BackgroundCardiovascular-kidney-metabolic syndrome, defined by the American Heart Association (AHA), is characterized by heart and kidney dysfunction. This dysfunction results from systemic inflammation and oxidative stress, which are caused by insulin resistance (IR) and severe obesity. This study explores the association between the monocyte/high-density lipoprotein-cholesterol ratio (MHR) and cardiovascular-kidney-metabolic syndrome, and its association with all-cause mortality.MethodsThe data for this study come from the National Health and Nutrition Examination Survey (NHANES) conducted from 2003 to 2018 and the National Death Index (NDI) database. Statistical analysis methods such as multiple logistic regression and Cox regression were employed. Additionally, restrictive cubic spline models and subgroup analyses were applied.ResultsThis study included 13,323 participants, of whom 2,452 were identified as having Cardiovascular-Kidney-Metabolic (CKM) syndrome. MHR levels differed significantly between participants with and without CKM syndrome. Weighted logistic regression showed that higher MHR was significantly associated with increased prevalence of CKM syndrome (OR: 1.19; 95% CI: 1.07-1.32). When MHR was analyzed by quartiles, the prevalence of CKM syndrome increased progressively across quartiles (Q4 vs. Q1, OR: 1.63; 95% CI: 1.27-2.11). Restricted cubic spline analysis revealed a nonlinear positive association between MHR and CKM syndrome (P-nonlinear < 0.001). Among participants with CKM syndrome, weighted Cox regression showed that MHR was significantly associated with all-cause mortality (HR: 1.04; 95% CI: 1.01-1.06). After covariate adjustment, restricted cubic spline analysis demonstrated a significant overall association between MHR and mortality (global P = 0.02), with no evidence of nonlinearity (P for nonlinearity = 0.48), suggesting a linear dose-response relationship. Subgroup analyses indicated that the association between MHR and all-cause mortality in CKM syndrome was generally consistent across subgroups, with no significant interactions detected.ConclusionOur study demonstrates that MHR is independently associated with a higher prevalence of CKM syndrome. Among patients with CKM syndrome, MHR showed a modest association with all-cause mortality. These findings suggest that MHR may have potential utility as a biomarker for CKM syndrome, although its prognostic value for mortality appears limited and warrants further prospective validation. - Source: PubMed
Publication date: 2026/09/09
Ji XuhouYu GuangzanLiu LuluMa QianHe Hua - Steatotic liver disease (SLD) is closely associated with cardiometabolic factors, but whether the cardiovascular-kidney-metabolic (CKM) stage stratifies risk for major adverse cardiovascular events (MACEs) and liver-related events (LREs) across SLD subtypes remains unclear. - Source: PubMed
Publication date: 2026/09/09
Fan Qiong-YueLian Li-YouXia Tian-YiChew Nicholas W SChen Qin-FenDong Yu-XingTargher GiovanniByrne Christopher DJiang XuWang Xiao-DongSperling Laurence SLip Gregory Y HChen Jun-KangHuang Yi-JiaJu Sheng-HongZhou Xiao-DongZheng Ming-Hua