Ask about this productRelated genes to: ApoA1 protein
- Gene:
- APOA1 NIH gene
- Name:
- apolipoprotein A1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: ApoA1 protein
Related articles to: ApoA1 protein
- Efficient lipid mobilization from yolk is critical for avian embryonic development, yet the cellular mechanisms governing lipoprotein transport in yolk sac membrane endodermal epithelial cells remain poorly characterized. Single-cell RNA sequencing was performed on 9,037 embryonic day 4 and 6,884 embryonic day 7 chicken yolk sac membrane cells to investigate lipoprotein biosynthesis pathways. Analysis identified 17 transcriptionally distinct clusters, including 3 endodermal epithelial cell subtypes. Cluster 2, characterized by high expression of epithelial markers (CDH1, EPCAM) and HDL biosynthesis genes (APOA1, ABCA1, LCAT), emerged as the primary site of HDL assembly. Apolipoprotein A1 ranked third in expression whereas apolipoprotein B ranked only 63rd, indicating a prominent HDL-biogenesis program in EECs. Gene ontology enrichment revealed upregulation of cholesterol metabolism and lipoprotein particle receptor binding pathways from embryonic day 4 to 7. Temporal expression analysis demonstrated progressive increases in HDL-related genes (APOA1, ABCA1, LCAT, SOAT1) throughout incubation, peaking at embryonic day 20, while VLDL-related genes (APOB, MTTP, SAR1B) showed sustained upregulation. Plasma analysis at embryonic day 19 confirmed HDL concentration (194.78 ± 30.13 mg/mL, mean ± SEM) significantly exceeded VLDL concentration (65.43 ± 13.82 mg/mL; P < 0.01), representing approximately 75% of measured lipoproteins. These findings reveal that HDL, rather than VLDL alone, plays a substantial role in lipid redistribution during late chicken embryogenesis, with HDL serving as the primary carrier of cholesteryl esters and phospholipids while VLDL remains the dominant triacylglycerol transporter, highlighting complementary lipoprotein functions and species-specific metabolic adaptations critical for embryonic development. - Source: PubMed
Publication date: 2026/04/17
Wu Jie-CiHu Zhao-QiLin Yuan-YuMersmann Harry JDing Shih-Torng - This study aims to examine whether daily salt intake (DSI) modifies the association between body mass index (BMI) and cardiometabolic indicators in a Beijing occupational population. - Source: PubMed
Publication date: 2026/04/22
Ren JiajuGuo YanqingZhu YanboCui YanJin LiHao WeiZhang Yanju - The egg laying process of poultry is determined by follicular development. In the present study, hens with lower egg production rates had significantly fewer small white follicles than those with higher rates. In order to investigate the regulatory mechanisms governing the development from white follicles to yellow follicles, transcriptome sequencing was performed on small white follicles (SWFs), small yellow follicles (SYFs) and F6 (the smallest hierarchical follicles) of high-yield laying hens. Pathways enrichment analysis revealed that the vascular endothelial growth factor (VEGF) signaling, peroxisome proliferator-activated receptor (PPAR) signaling, tight junction and gap junction pathways, as well as steroid hormone biosynthesis were involved in follicular development. Compared with the transition from SYFs to F6, the transition from SWFs to SYFs showed more pronounced changes in gene expression profiles. This was validated by Western blot analysis, which revealed significantly upregulated expression of angiogenesis-related proteins (VEGF, VEGFR1, VEGFR2, ANGPT1 and ANGPT2) and downregulated expression of pigment epithelium derived factor (PEDF) in SYFs compared to SWFs. Immunofluorescence staining (IF) confirmed a markedly higher CD31-positive staining area in the theca layer of SYFs than in that of SWFs. Meanwhile, the estradiol (E) and progesterone (P) levels in SYFs increased by 131.6% and 22.2%, respectively, compared to SWFs. At the transcript level, SYFs exhibited upregulation of apolipoprotein D (ApoD), apolipoprotein A1 (APOA1), apolipoprotein L (APOLD1), PPAR and very low-density apolipoprotein (VLDL) mRNA, alongside downregulation of occludin, which was further confirmed by increased VLDLR and PPAR-γ protein abundance and decreased occludin levels. In summary, our results revealed that the SWFs to SYFs transition proceeds with pronounced changes in transcriptional profiles associated with angiogenesis, sex steroid biosynthesis and yolk deposition. The increased steroid hormone production likely enhances the capacity for yolk synthesis. Furthermore, the elevated vascularization in the theca layer of SYFs in coupled with a reduction in tight junctions may facilitate the transport of yolk precursors to access the follicles. - Source: PubMed
Publication date: 2026/05/01
Ma YanfenZhou ShuoMi YulingZhang Caiqiao - [This corrects the article DOI: 10.3389/fcvm.2024.1381520.]. - Source: PubMed
Publication date: 2026/04/20
La Chica Lhoëst M TMartinez AClaudi LGarcia EBenitez-Amaro APolishchuk APiñero JVilades DGuerra J MSanz FRotllan NEscolà-Gil J CLlorente-Cortés V - The most common ocular neoplasia among children is retinoblastoma. Currently, the diagnosis of this disease is essentially clinical, taking a biopsy is contraindicated owing to the high risk of causing metastasis. Therefore, it is imperative the development of a method to diagnose this disease through a non-invasive fashion. We choose tears as they fulfill the former precept. Through proteomic analysis we observed 52 up regulated and 48 down regulated proteins among retinoblastoma cases as compared to healthy children. Among these proteins, we identified several previously associated with retinoblastoma such as apolipoprotein A-1 (). We confirmed up regulation of and S100 binding calcium A9 () which revealed faithful concordance to the predicted values from mass spectrometry. - Source: PubMed
Publication date: 2026/04/22
Rodríguez-Rodríguez AndrésCalderón-González Karla GriselLuna-Arias Juan PedroMoctezuma-Dávila MarianaRangel-Charqueño MarthaYañez-Soto BernardoOlivares-Illana VanesaHernández-Monge Jesús