Ask about this productRelated genes to: IGFBP4 antibody
- Gene:
- IGFBP4 NIH gene
- Name:
- insulin like growth factor binding protein 4
- Previous symbol:
- -
- Synonyms:
- IBP4, BP-4, HT29-IGFBP, IGFBP-4
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-09
- Date modifiied:
- 2015-11-12
Related products to: IGFBP4 antibody
Related articles to: IGFBP4 antibody
- Anti-CD3 monoclonal antibody (aCD3) delays progression to stage 3 type 1 diabetes in high-risk individuals by modulating autoimmune activity. Nevertheless, responses remain variable and transient, with therapy providing only indirect beta cell protection. We investigated whether glucagon-like peptide-1-17ß-oestradiol conjugate (GLP1-E2), a beta cell-targeted fusion compound that enhances beta cell survival and function, could potentiate a short low-dose aCD3 course in preventing autoimmune diabetes in NOD mice. We hypothesised that co-targeting immune dysregulation and beta cell fragility would provide complementary and potentially synergistic benefits, resulting in more durable protection than either monotherapy. - Source: PubMed
Publication date: 2026/05/18
Degroote LaureChrzanowski JędrzejLemaitre PierreWouters AmberBourgeois StephanieVan Mulders AnnelorePierreux JulieCoenen SophieWillems LienLeuckx GunterViaene MarijkePackbier MarcDouros Jonathan DYang BinHeremans YvesMathieu ChantalStaels WillemGysemans ConnyDe Leu Nico - Dental-derived mesenchymal stem cells show considerable variability in their differentiation potential due to the use of nonspecific surface markers and technical limitations in isolation protocols. This study aimed to employ single-cell RNA sequencing to compare the cellular composition of cultured stem cells from apical papilla (SCAPs) and dental pulp (DPSCs), with the goal of detecting subpopulations underlying their divergent regenerative behaviour and identifying markers that can facilitate future isolation and functional targeting. - Source: PubMed
Publication date: 2026/05/05
Shah Maanas SSayegh Mohamed AlKhalil Mennatullah MSundarabupathi ManoAlKhnbashi OmerSamaranayake LakshmanKhyriem CosterwellSultana MeharEgusa HiroshiJamal Mohamed - IGFBP4 is essential for adipogenesis and is highly expressed in adipocytes and osteoblasts of mice. However, its role in bovine adipogenesis, especially intramuscular adipogenesis, remains unknown. Here, we cloned the CDS of IGFBP4 from Qinchuan cattle and analyzed its protein structure and function. We measured its expression levels in various tissues. The CDS region of the bovine IGFBP4 gene was 777 bp long, encoding a protein of 259 amino acids. The in-silico analysis revealed sequence conservation of Bos mutus and Bos indicus, while variation was found in Mus musculus and Rattus norvegicus sequences. The physical and chemical properties of the IGFBP4 protein exhibited an isoelectric point of 7.10 and a molecular mass of 27.89 kDa. The protein was predicted to be hydrophilic and lacked a transmembrane structure, with potential phosphorylation and glycosylation sites. Interaction analysis suggested associations with several other proteins. Regarding tissue expression, the mRNA level of the IGFBP4 gene was highest in the liver, lowest in muscle, and significantly higher in subcutaneous fat compared to intramuscular fat in Qinchuan beef cattle. These findings indicate a potential role of theIGFBP4 gene in regulating bovine adipogenesis and lipid metabolism. This study provides a foundation for exploring the underlying molecular mechanism of intramuscular fat deposition in cattle. - Source: PubMed
Publication date: 2026/05/06
Song RuiruiLi BingzhiWang SihuAlenize MaryamZhao YanqingKaabi Aaishah M HDeebani Afnan OAlShammari WasimahAlenizi DalalAlardan DalalZhang Wenzhen - The implantation period is crucial for the establishment of pregnancies in cows. Interferon τ (IFNτ) is produced during early implantation and acts in autocrine, paracrine and endocrine fashions on other endocrine systems. One of these is the insulin-like growth factor 1 (IGF-1) system, which is important for cell growth, proliferation, and therefore pregnancy establishment. This study investigated the effect of IFNτ on the expression of hepatic IGF-binding proteins (IGFBPs) in vitro. Primary bovine hepatocytes in a 2D sandwich culture model were stimulated with recombinant bovine IFNτ (rbIFNτ; 0.1-10.0 ng/mL) for six hours. The mRNA expression of IGFBP-1 to -7 and acid labile subunit (ALS) was measured using qRT‒PCR, and protein production was confirmed using western ligand blotting. All the IGFBPs (1-7) and ALS were expressed at basal levels in primary bovine hepatocytes, with IGFBP-2 to -4 secreted at appreciable concentrations in the medium. The expression of IGFBP-2 to -6 was stimulated by IFNτ, (treatment with rbIFNτ vs. control; IGFBP-2: for 0.5 ng/mL rbIFNτ, p = 0.0166; IGFBP-3: for 0.5 ng/mL, 5.0 ng/mL, and 10.0 ng/mL rbIFNτ, p = 0.0293, p = 0.0252, and p = 0.0099; IGFBP-4: for 0.5 ng/mL rbIFNτ, p = 0.0024; IGFBP-5: for 0.5 ng/mL and 10 ng/mL rbIFNτ, p = 0.0008 and p = 0.0421; IGFBP-6: for 0.1-10.0 ng/mL rbIFNτ, p = 0.0498-0.0022). These results indicate modulation of the IGF-system through IFNτ, which may contribute to adaptations supporting the early establishment of pregnancies in cattle. - Source: PubMed
Publication date: 2026/04/28
Schnieders ChristinaScholl ChristinaHoeflich AndreasSchmicke Marion - Hypertension is a major modifiable risk factor for chronic kidney disease (CKD), yet predicting which hypertensive individuals will progress to CKD remains challenging. We aimed to develop and validate a plasma protein-based risk score for incident CKD in hypertension and to identify causal proteins and potential therapeutic targets. - Source: PubMed
Publication date: 2026/04/22
Huang YuChen DanYe ZiliangZhang YanjunYang SisiGan XiaoqinZhang YiweiWu YitingZhang YuanyuanQin Xianhui