Ask about this productRelated genes to: CD40L antibody
- Gene:
- CD40LG NIH gene
- Name:
- CD40 ligand
- Previous symbol:
- HIGM1, IMD3, TNFSF5
- Synonyms:
- CD40L, TRAP, gp39, hCD40L, CD154
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD40L antibody
Related articles to: CD40L antibody
- Neuroimmune signaling across the peripheral-vascular-glial axis is increasingly recognized as a driver of both age‑related brain vulnerability and the earliest stages of neurodegenerative disease, including Alzheimer disease. Evaluating this axis in vivo remains challenging due to limited neuroinflammatory imaging biomarkers. We utilized [11C]CS1P1 positron emission tomography (PET) to quantify sphingosine-1-phosphate receptor 1 (S1PR1) availability alongside plasma proteomics in 42 cognitively normal individuals (age 21-82). Through differential abundance analysis and structural equation modeling (SEM), we identified a multi-compartment neuroimmune cascade linking peripheral T-cell activation (CD40LG), vascular endothelial disruption (ICAM1/TEK), central S1PR1 upregulation, and reactive astrogliosis (GFAP). Mediation analysis estimated this S1PR1 axis accounts for 25.5% of the total effect of CD40LG on GFAP. This cascade appears coupled to the astrocytic immune response and is exacerbated by underlying amyloid-beta pathology. These findings suggest [11C]CS1P1 may serve as an in vivo tool for evaluating peripheral-to-central immune crosstalk. - Source: PubMed
Publication date: 2026/04/19
Benzinger TammiePowles Savannah TiemannHoagey DavidFlores ShaneyFriedrichsen KarlWu ShuangRajamanickam JayashreeJoseph-Mathurin NellyKeefe SarahNagy SydneyMcKay NicoleWisch JulieSabaredzovic EditaChen GengshengSimmons AshleeJones LynneSoda Anil KumarPowles JonathanDoering StephanieJana NayidMassoumzadeh ParinazBaker BryceCruchaga CarlosSchindler SuzanneIbanez LauraMorris JohnAn HongyuLiu JingxiaTu ZhudeBrier Matthew - Whole blood transfusion is increasingly used in trauma resuscitation. However, stored whole blood units demonstrate increasing susceptibility to tissue plasminogen activator-mediated fibrinolysis despite paradoxical increases seen in plasminogen activator inhibitor-1 (PAI-1) activity over time. Whether early variability in PAI-1activity exists across whole blood units and the biologic contributors to this variability remain unclear. Two distinct donor pools were identified: one with high PAI-1 activity and one with low PAI-1 activity. We set out to determine whether PAI-1 activity in whole blood donors primarily comes from the endothelium or from platelet degranulation. - Source: PubMed
Publication date: 2026/04/23
Maginot Elizabeth RBarmettler Nicolle KGawargi Flobater IMoore Ernest EWhite Collin MHiser Dylan CClegg Ashley ASextro Kyle SMoody Trace BVolk Grace EMoore Hunter BGoodman NatashaBobr AlehHenry ReynoldBarrett Christopher D - The bidirectional interaction between inflammation and thrombus formation plays an important role in myocardial infarction (MI) with IL (interleukin)-6 as a central mediator. If anti-inflammatory therapy modulates coagulation factors, and platelet activation in patients with MI is not clear. - Source: PubMed
Publication date: 2026/04/23
Ueland ThorDahl Tuva BMichelsen AnnikaKleveland OlaAndersen Geir ØysteinAnstensrud Anne KristinHuse CamillaWoxholt SindreBroch KasparGullestad LarsLibby PeterAukrust PålHalvorsen Bente - IL-10-producing B cells exert immunosuppressive effects, yet their low abundance and poor in vitro viability have limited their therapeutic application. Here, we developed a stromal coculture system using MS5 cells engineered to express human CD40L, BAFF, and IFN-β1 (MS5-3F, for "3 factors"), which enables robust induction and greater than 1000-fold expansion of human IL-10-producing B cells. The expanded cells showed phenotypic and transcriptional profiles characteristic of unswitched (IgM+) plasmablasts and potently suppressed CD4+ T cell proliferation in an IL-10-dependent manner. MS5-3F-expanded B cells also increased the frequency of regulatory T cells in vitro, an effect that was not abrogated by IL-10/IL-10R blockade, suggesting contributions from additional mechanisms. IL-10 production originated predominantly from naive B cells, rather than memory B cells. Furthermore, B cells from patients with systemic lupus erythematosus, despite impaired IL-10 production under conventional conditions, were efficiently differentiated into IL-10-producing B cells using this system. The expanded cells showed minimal IgG-secreting output. Our platform offers a scalable strategy for generating human regulatory B cells, laying the foundation for B cell-based immunotherapies. - Source: PubMed
Publication date: 2026/04/22
Kawakami RyoImabayashi KeisukeBaba AkemiSaito YuichiKawata KazuhikoYada YutaroShibata AiriIto RinkaKurasawa RyoHiguchi RyotaPark SungyeonNiiro HiroakiTanaka ShinyaBaba Yoshihiro - - Source: PubMed
Publication date: 2026/04/21
Alroqi FayhanAlJaber Abdulrahman NAlthubaiti NoufAl Tuwaijri AbeerAlzaaqi ShouqBarhoumi TliliAlmutairi AbduarahmanAlmuzzaini BaderAlsayegh LeenaNogoud MaysaAljedaie Modhi