Ask about this productRelated genes to: CD90 antibody
- Gene:
- THY1 NIH gene
- Name:
- Thy-1 cell surface antigen
- Previous symbol:
- -
- Synonyms:
- CD90
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2015-07-22
Related products to: CD90 antibody
Related articles to: CD90 antibody
- Understanding the chronic effects of intracortical microstimulation (ICMS) and device implantation on cortical function is essential for the development of stable neuroprosthetics. We chronically implanted penetrating microelectrodes into Thy1-GCaMP6s mice and conducted longitudinal mesoscopic widefield and two-photon Ca imaging alongside intrinsic optical signal recordings over 12 weeks. Six ICMS frequencies (10-500 Hz) and contralateral visual LED stimuli were delivered in repeated sessions. Oxygen extraction fraction (OEF) was estimated from dual-wavelength reflectance, and hemodynamic response functions (HRFs) were derived via regularized deconvolution. Over the chronic period, 25-Hz ICMS evoked progressively larger Ca responses with extending duration, while spatial spread remained stable after the first few days. Low-frequency ICMS preserved stable Ca depression, whereas high-frequency ICMS and visual stimulation showed partial declines in depression magnitude and spatial extent. Two-photon imaging revealed that somatic and neuropil compartments followed distinct activation and depression trajectories, with somatic ICMS responses declining then recovering while neuropil activation tracked mesoscale trends. Concurrently, OEF reductions deepened, reflecting increased relative blood supply, and the spatial extent of OEF signals contracted in the first week before expanding by day 21. Epileptiform Ca events emerged in nearly half of mice, predominantly under 25-Hz ICMS. HRF peak amplitude increased between day 0 and days 7-21, with latency decreasing. Spontaneous neural and hemodynamic activity near the probe was suppressed acutely but recovered over weeks. Chronic ICMS induces progressive potentiation of neuronal and vascular responses alongside local neurovascular uncoupling on day 0 and sustained silencing of spontaneous activity near the implant. These dynamics stabilized 6-7 weeks after implantation. The frequency-dependent epileptiform susceptibility, coupled with persistent focal neurovascular deficits, underscores the need for adaptive stimulation strategies during the pre-stabilization period and electrode designs that mitigate local suppression to ensure long-term stability of cortical neuroprostheses. - Source: PubMed
Publication date: 2026/05/02
Suematsu NaofumiVazquez Alberto LKozai Takashi Dy - Immunoglobulin A nephropathy (IgAN), the most common primary glomerulonephritis globally, leads to a high lifetime risk of kidney failure. Shenhua Tablet (SHT), a Chinese herbal formula, demonstrates clinical efficacy in IgAN. Paeoniflorin (PF), its principal active constituent, shows anti-inflammatory and renoprotective effects in preclinical models; however, its precise molecular mechanisms in IgAN remain unclear. - Source: PubMed
Publication date: 2026/05/01
Wang MengmengYin FengtingLi PingHan JinweiZheng YingYan GuangliLiu ChangWang YuhangChen XiangmeiYan XiaotongSun HuiGuan ShihanWang Xijun - Severe, gap-type peripheral nerve injuries often require surgical intervention in the form of a nerve autograft or synthetic nerve guidance scaffold to promote axonal regeneration and functional recovery. In this study, nerve guidance conduits (NGCs) were fabricated from aligned polycaprolactone (PCL) nanofibres with or without encapsulated glial cell line-derived neurotrophic factor (GDNF), and a fibrin sealant-based hydrogel. These constructs were evaluated in a murine sciatic nerve transection model using Thy1-YFP-H mice, allowing regenerating axons to be visualised in transverse sections throughout the constructs. Both PCL + GDNF and PCL-only conduits facilitated Schwann cell migration and successful axonal regeneration across the site of injury. Nerve autografts, the positive control, demonstrated the highest regenerating axon count in the distal stump, although statistical significance was not observed between groups. These results demonstrate that NGCs fabricated using aligned PCL nanofibres reliably facilitate nerve regeneration across nerve gaps to a degree, but require further investigation for application in peripheral nerve repair. Future studies that optimise growth factor delivery and conduit design would be beneficial to improve regenerative outcomes. - Source: PubMed
Publication date: 2026/05/05
Johnson Louis D VGregory Holly NPhillips James BMemarpour Hobbi SaraBoissonade Fiona MClaeyssens Frederik - Dental-derived mesenchymal stem cells show considerable variability in their differentiation potential due to the use of nonspecific surface markers and technical limitations in isolation protocols. This study aimed to employ single-cell RNA sequencing to compare the cellular composition of cultured stem cells from apical papilla (SCAPs) and dental pulp (DPSCs), with the goal of detecting subpopulations underlying their divergent regenerative behaviour and identifying markers that can facilitate future isolation and functional targeting. - Source: PubMed
Publication date: 2026/05/05
Shah Maanas SSayegh Mohamed AlKhalil Mennatullah MSundarabupathi ManoAlKhnbashi OmerSamaranayake LakshmanKhyriem CosterwellSultana MeharEgusa HiroshiJamal Mohamed - Osteoarthritis (OA) is characterized by a chronic inflammatory microenvironment accompanied by elevated reactive oxygen species (ROS), synovial immune dysregulation, and progressive cartilage degeneration. While conventional pharmacological treatments often exhibit limited efficacy in halting disease advancement, we report a biomimetic, ROS-responsive nanoparticle (NPs) delivery system coated with macrophage membranes (MM-shTHY1-NPs) to achieve targeted therapy. The macrophage membrane (MM) coating not only improves retention and targeting toward inflamed synovial tissues, but also provides cytokine-scavenging capability that helps buffer the inflammatory microenvironment. Within the oxidative joint microenvironment, the ROS-responsive architecture of the NPs-facilitated by diselenide bonds-triggers the site-specific release of shTHY1 payloads. Importantly, we demonstrated the therapeutic relevance of THY1 silencing in OA microenvironment remodeling; both in vitro and in vivo experiments demonstrate that shTHY1 delivery effectively promotes macrophage repolarization from a pro-inflammatory M1 to an anti-inflammatory M2 phenotype. This phenotypic shift subsequently remodels the chondrocyte microenvironment, suppressing matrix metalloproteinase expression and attenuating cartilage degradation. The synergy between RNAi-mediated THY1 silencing and the cytokine-scavenging capability of the macrophage membrane coating resulted in enhanced therapeutic efficacy. Our findings suggest that this cell-membrane-coated nanoplatform provides a promising strategy for the treatment of inflammatory joint diseases, with potential advantages in biosafety, site-specific delivery, and translational feasibility. - Source: PubMed
Publication date: 2026/04/21
Hu XinyueLi ZhuangLi XiaofeiZhang LingxiaoZhang Yaqing