Ask about this productRelated genes to: IL2R antibody
- Gene:
- IL2RA NIH gene
- Name:
- interleukin 2 receptor subunit alpha
- Previous symbol:
- IL2R, IDDM10
- Synonyms:
- CD25
- Chromosome:
- 10p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-22
- Date modifiied:
- 2019-04-23
Related products to: IL2R antibody
Related articles to: IL2R antibody
- Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a Th2 disease characterized by heterogeneous mast cell hyperplasia. We previously used transcriptomics to identify discrete gene expression linked with intraepithelial MCs expressing tryptase alone (MC), subepithelial MCs co-expressing tryptase and chymase (MCs), and immature MCs in CRSwNP. While MCs were the only subset consistently observed in both CRSwNP and control CRS donors without nasal polyposis (CRSsNP), the degree to which they differ across disease states remains unexplored. - Source: PubMed
Publication date: 2026/04/25
Santos Rizza USuber JadaDerakhshan TaherehNiharika Gullapalli Sri VidyaMatsuda KenshiroZawacki Mabel CLai JuyingBergmark Regan WLee Stella EMaxfield Alice ZRoditi Rachel EBaloh Carolyn HLaidlaw Tanya MBoyce Joshua ADwyer Daniel F - Gene expression in regulatory T cells (Tregs) is context-dependent and maintains peripheral immune homeostasis. FOXP3 is lineage defining but not sufficient for Treg function or persistence. To define the cell-intrinsic roles of the FOXP3 paralogs FOXP1 and FOXP4, we generated and studied mice with Treg-specific deletion of and/or . FOXP1 and FOXP4 are required to maintain the peripheral Treg pool through enhancing transcription, thereby promoting sustained high-level expression of IL-2Rα and thus of the high-affinity IL-2Rαβγ complex. Integrating RNA-seq and ATAC-seq with previously published ChIA-PET and publicly available data, we propose a model of transcriptional regulation in which in which FOXP1 and FOXP4 anchor chromatin looping of the locus in mature Tregs, augment super-enhancer activity, and drive sustained CD25 expression. Our results reveal a unique role of FOXP1, and to a lesser extent FOXP4, in controlling Treg homeostasis. - Source: PubMed
Publication date: 2026/04/17
Dong DachuanHigdon Lauren EZhou JiayanLin Jian-XinPadiapu JyothiKim YeslLeonard Warren JMaltzman Jonathan S - Crohn's disease (CD) and ulcerative colitis (UC) share common features of inflammation to a greater extent in children than in adults. However, histopathological scoring systems of mucosal inflammation are usually available only for either one of these entities. The IBD-DCA score is the first of its kind to incorporate both into one scoring system but still lacks validation in pediatric IBD. - Source: PubMed
Publication date: 2026/03/28
Schnell AlexanderWei XinyiBossenz JanManuilova IrynaChristoph JanAllabauer IdaClassen MerleRegensburger Adrian PWoelfle JoachimErber RamonaHoerning André - Primary central nervous system lymphoma (PCNSL) is a rare and aggressive B-cell lymphoma in which early diagnosis remains challenging. Although cerebrospinal fluid (CSF) B-cell-associated factors including soluble interleukin-2 receptor subunit alpha (IL-2RA) are known diagnostic markers, they often reflect neuroinflammation and are insufficient on their own to reliably differentiate PCNSL from neuroimmunological diseases. On the other hand, CSF immune checkpoint molecules reflect neuro-immune regulation and remain incompletely evaluated as biomarkers for PCNSL. We aimed to determine whether CSF immune checkpoint molecules can serve as additional diagnostic and prognostic biomarkers for PCNSL alongside B-cell-associated factors. - Source: PubMed
Publication date: 2026/04/02
Nishii ShotaAkatani RitsuShiroma KyokaTakeda RyosukeTsuji AsatoKatanazaka KimitakaMatoba KentoOtani MayumiKoto ShusukeTanaka KazuhiroNagashima HiroakiSekiguchi KenjiSasayama TakashiChihara Norio - The study attempted to investigate the clinical value of serum cytokine levels in diagnosing colorectal cancer. Peripheral blood samples were obtained from 56 patients with colorectal cancer (colorectal cancer group) and 25 healthy subjects (control group) diagnosed in the Pathology Department at Shanxi Cancer Hospital between April 2020 and November 2020. The levels of 14 serum cytokines (interleukin (IL)-1β, L-17 A, IL-10, IL-4, IL-5, IL-6, IL-8, IL-22, IL-33, IL-18, IL-2RA, tumor necrosis factor (TNF)-α, TNF-β, and interferon (IFN)-γ) were analyzed using AimPlex flow cytometry high-throughput multi-factor detection technology. IL-2RA and IL-6 levels were significantly higher in the serum of patients with colorectal cancer than in the control group (P < 0.01), and the difference was of high statistical significance. IFN-γ, IL-8, and IL-5 levels were generally higher in the colorectal cancer group than in the control group (P < 0.05), and this difference exhibited statistical significance. The logistic regression model revealed that the colorectal cancer risk increased by 4.66 times for each increase in IL-6 (pg/mL) (P < 0.01), and by 3.01 times for each increase in IFN-γ (pg/mL) (P < 0.05). The Bayesian Kernel Machine Regression model indicated that the colorectal cancer risk increased by 0.95 times when all cytokines were at 75% compared to when at 50%. Furthermore, when the remaining cytokines were exposed at P50, the single factor exposure model showed that the levels of IL-6, IFN-γ, and TNF-β increased from P25 to P75. In contrast, the risk of colorectal cancer associated with these cytokines increased by 0.29 times, 0.248 times, and 0.4919 times. Meanwhile, a positive association was observed between the mixed effects of the 14 cytokines and the occurrence of colorectal cancer. This study's multi-method analysis demonstrated that colorectal cancer patients had significantly higher serum levels of IL-2RA and IL-6 (P < 0.01) and elevated IFN-γ, IL-8, and IL-5 levels (P < 0.05). Multivariate logistic regression showed that IL-6 (P < 0.01) and IFN-γ (P < 0.05) were strongly associated with disease risk (1-unit Ln increase raised the risk by 4.66- and 4.01-fold, respectively). RCS confirmed that IL-6 (with/without Ln transformation) and Ln-transformed IL-10 correlated positively with incidence (all P < 0.05). BKMR indicated the 14-cytokine mixed exposure at the 75th vs. the 50th percentile increased risk by 0.95. The mixed effect of the 14 cytokines detected using the mixed detection method positively correlated with the occurrence of colorectal cancer. These findings provide novel diagnostic insight for colorectal cancer. - Source: PubMed
Publication date: 2026/03/28
Hui YihuaChu MinWang HainaRen LaifengWu JinyuNiu XiaoyangZhang LiSu Wen