Ask about this productRelated genes to: VEGFR3 antibody
- Gene:
- FLT4 NIH gene
- Name:
- fms related tyrosine kinase 4
- Previous symbol:
- -
- Synonyms:
- VEGFR3, PCL
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-10-25
- Date modifiied:
- 2016-10-05
Related products to: VEGFR3 antibody
Related articles to: VEGFR3 antibody
- Blood group antigens are well known for their importance in transfusion medicine and transplant compatibility; however, their biological role extends beyond these functions and includes associations with the risk of several diseases. In this study, we investigated the relationship between ABO blood groups and the circulating levels of 73 different molecules. - Source: PubMed
Publication date: 2026/06/19
Di Salvo AlessiaMotisi ChiaraBulati MatteoScola LetiziaBalistreri Carmela Rita - There are a few molecules that are regularly used as markers for lymphatic endothelial cells (LECs) such as the adhesion molecule CD31/PEACAM1, the transcription factor PROX1, the Vascular Endothelial Growth Factor Receptor-3 (VEGFR3/), the glycoprotein podoplanin, and the hyaluronan receptor LYVE1. However, none of the molecules are exclusively expressed in LECs, and there is molecular and functional heterogeneity of LECs in initial lymphatics, lymphatic collectors and lymph nodes. Therefore, a combination of markers must be applied to identify lymphatics. This is particularly true for the characterization of conditions such as lymphatic malformations or cancers, in which the molecular profile of vessels may be variable or abnormal. Here we present two molecules that can help distinguish between endothelial cells of blood and lymphatic vessels: the scaffold protein liprin β-1 (PPFIBP1) and the intermediate filament synemin. We collected own data on the RNA and protein expression of the two molecules in humans, and studied publicly available databases. PPFIBP1 appears to be a suitable marker of LECs in initial lymphatics, collectors and lymph nodes, while synemin appears to be more restricted to initial lymphatics. We hope this will stimulate monoclonal antibody development and help expand the range of LEC markers in health and disease. - Source: PubMed
Publication date: 2026/06/10
Becker JürgenWilting Jörg - Paraneoplastic neurological syndromes (PNSs) are rare autoimmune diseases that occur in the context of cancer, but the mechanisms leading to immune tolerance breakdown remain unknown. Breast cancers (BCs) associated with Yo-PNS and Ri-PNS show distinct immune and genetic specificities, suggesting that tumour characteristics may contribute to autoimmunity. Herein, we aimed to investigate whether PNS-associated BCs display additional specificities, including stromal and vascular features that have not been systematically assessed. - Source: PubMed
Publication date: 2026/06/17
Nicola CelestePeter EliseVillagran-Garcia MacarenaTreilleux IsabellePicard GéraldineRogemond VéroniqueVillard MarineLopez JonathanJoubert BastienHonnorat JérômeWucher ValentinDesestret Virginie - To provide more treatment options for patients with advanced lung cancer, this study aims to identify new therapeutic drug targets via the integration and analysis of multi-omics datasets. - Source: PubMed
Publication date: 2026/06/09
Meng PeizeZhang ZhipingRuan ZhengXu Congcong - Pulmonary arterial hypertension (PAH) is characterized by excessive remodeling of the distal arterioles and arteries, driven by endothelial cell (EC) apoptosis and uncontrolled mural cell proliferation. Increasing evidence suggests immune dysregulation in PAH, but one crucial part of the immune system, the pulmonary lymphatics, has been largely overlooked. Patients with idiopathic PAH (IPAH) often develop abnormal tertiary lymphoid structures adjacent to remodeled arteries, yet the role of lymphatics in PAH pathogenesis and vascular remodeling remains unclear. - Source: PubMed
Publication date: 2026/06/03
Moss M ElizabethKlouda TimothyLi YanLiu YuTan MengKim YunhyeHao YuanTian WenNicolls Mark RWu Joseph CBucala RichardChen HongLee EungjooTran-Lundmark KarinRaby Benjamin AYuan Ke