Ask about this productRelated genes to: VEGFR3 antibody
- Gene:
- FLT4 NIH gene
- Name:
- fms related tyrosine kinase 4
- Previous symbol:
- -
- Synonyms:
- VEGFR3, PCL
- Chromosome:
- 5q35.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-10-25
- Date modifiied:
- 2016-10-05
Related products to: VEGFR3 antibody
Related articles to: VEGFR3 antibody
- Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases. We report ES findings in the remaining cohort and investigate the incremental yield of genome sequencing (GS) in cases without a definitive diagnosis from exome. Enrollment criteria and exome methodology for the Hydrops-Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) study were previously reported. Exomes without a definitive diagnosis were reviewed with updated clinical information and had GS if DNA was available. A genetic counselor returned the clinical reports. Overall, 50 exomes yielded 22 (44%) diagnoses and six possible diagnoses (12%). Nine new cases (9/28, 68%) had a diagnosis involving one of the following genes: RIT1, SOS1, RYR1, FLT4, LMOD2, KMT2D, PUF60, and BLTP1. Two additional cases were diagnosed upon reclassification of uncertain variants. GS of eligible ES cases resulted in an incremental diagnostic yield of 7% (1/14). ES and GS in NIHF significantly reduce the number of unexplained cases and guide clinical management and recurrence risks. Currently, the incremental diagnostic yield of GS over ES in NIHF remains under investigation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03911531. - Source: PubMed
Publication date: 2026/08/20
Rice Stephanie MMakhamreh Mona MWodoslawsky SaschaToro MariellaCritchlow ElizabethFirman BrandyLiu RubyNallamilli Babi RameshHegde MadhuriBerger Seth IAl-Kouatly Huda B - Bone regeneration relies on specialized vascular niches, yet the contribution of lymphatic vessels across distinct skeletal sites remains poorly understood. Here, we identify bone lymphatics as an essential component of the regenerative microenvironment in the mandible and long bones. We demonstrate that bone lymphatic endothelial cells (LECs) constitute a specialized endothelial population that is transcriptionally and spatially distinct from periosteal LECs. During skeletal repair, bone LECs reactivate a regenerative transcriptional programme, and promote mandibular and fracture healing. In osteonecrosis of the jaw and periodontitis, bone lymphatic-associated signalling is disrupted, identifying impaired lymphatic function as a shared feature of mandibular disease. Therapeutic activation of VEGFC-FLT4 signalling during injury or mandibular disease restores lymphangiogenesis, enhances osteogenesis, and markedly improves bone regeneration. Together, our findings advance the paradigm-shifting role of bone lymphatics positive regulators of bone regeneration and identify lymphatic activation as a promising therapeutic strategy to enhance bone regeneration in mandibular diseases. - Source: PubMed
Publication date: 2026/08/06
Jain SanyamLi JieZhang JiayuanCai HeWu YufeiYang YangYe MinghanRisbud Makarand VChen JunyuKusumbe Anjali P - Milroy's disease is a rare hereditary primary lymphedema, typically presenting at birth or early infancy with chronic lower limb swelling due to mutations in the gene encoding VEGFR-3. While congenital lymphedema is the hallmark, its association with tubercular pericardial effusion leading to tamponade is extremely rare. We report an 18-year-old female with longstanding bilateral lower limb lymphedema who presented with progressive dyspnea and fever. Evaluation revealed tubercular pericardial effusion, and genetic testing confirmed an mutation. The patient improved with antitubercular therapy and supportive care. This case emphasizes the need to consider rare systemic complications in congenital lymphedema syndromes to optimize early diagnosis and management. - Source: PubMed
Khan KhalidQuazi TubaJalgaonkar PradeepBhrushundi MilindQuazi Sabiha - Early onset preeclampsia (EOPE), a complex complication of pregnancy, is a major contributor to maternal and fetal morbidity and mortality. The only symptom consistently observed in EOPE is new maternal hypertension. Other symptoms vary among patients, posing challenges for early detection. There are currently no clinically accepted molecular markers other than FLT1, which is highly upregulated and displays a small change in its splicing ratio in EOPE placentas. However, an exhaustive search for changes in transcript use in EOPE has not been performed. - Source: PubMed
Publication date: 2026/07/17
Grinshpan NufarMizrachi TehilaLianski SapirZarivach RazGoldman-Wohl DebraBeharier OferShay Tal - Ovarian senescence is the fundamental cause of reduced fertility in female animals,however, the molecular characteristics of ovarian ageing in sheep remain insufficiently defined. In this study, ovarian tissues were collected from 12 Qira Black sheep and assigned to group D (1-2 years, = 6) and group H (5-6 years, = 6) for LC-MS/MS-based proteomic profiling. A total of 458 differentially expressed proteins (DEPs) were identified between the two groups, including 211 upregulated and 247 downregulated proteins. Functional enrichment analyses indicated that these DEPs were mainly involved in cell-cycle regulation, oocyte maturation, amino acid metabolism, and inflammation-related signalling pathways, with the Rat Sarcoma(Ras) and Mitogen-Activated Protein Kinase Pathway(MAPK) signalling pathways showing particularly strong enrichment. Protein-protein interaction (PPI) network analysis revealed close interactions among Intraflagellar transport 80(IFT80), Insulin receptor(INSR), Angiopoietin-like 4(ANGPTL4), Receptor interacting serine/threonine kinase 3(RIPK3), Nuclear receptor corepressor 1(NCOR1), and Fms-Related Tyrosine Kinase 4(FLT4), with Insulin receptor(INSR) occupying a central hub position. Collectively, this study establishes a differential proteomic atlas of ovarian ageing in Qira Black sheep, highlights the potential importance of Rat Sarcoma(Ras) and Mitogen-Activated Protein Kinase Pathway(MAPK) signalling in this process, and identifies Insulin receptor(INSR) as a candidate target, thereby providing a theoretical basis for subsequent mechanistic studies and the development of molecular markers. - Source: PubMed
Publication date: 2026/06/30
Guo PeilinPei LinlinLiu NingjieWang WenhaoQiao AndiXu XinLiu Chunjie