Ask about this productRelated genes to: MMP3 antibody
- Gene:
- MMP3 NIH gene
- Name:
- matrix metallopeptidase 3
- Previous symbol:
- STMY1, STMY
- Synonyms:
- -
- Chromosome:
- 11q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: MMP3 antibody
Related articles to: MMP3 antibody
- Diabetic kidney disease (DKD) is significantly impacting both quality of life and survival rates. The Shen-Yan-Fang-Shuai (SYFS) formula is a traditional Chinese medicine (TCM) compound widely used in the clinical treatment of DKD with proven efficacy, though its potential mechanism of action remains unclear. This study attempts to elucidate the therapeutic efficacy, mechanisms of action, and active compounds of the SYFS formula in the treatment of DKD. - Source: PubMed
Kang YiJin QianZhou MengqiZheng HuijuanLi DanwenWang XuezheZhou JingweiLv JieWang Yaoxian - Postmenopausal females are at increased risk of intervertebral disc (IVD) degeneration due to estrogen decline. While both estrogen supplementation and low-magnitude high-frequency vibration (LMHFV) are proposed as therapies for osteoporosis, their effects and potential interactions on IVD degeneration remain unclear. Therefore, the aim of this work was to investigate the individual and combined effects of 17β-oestradiol (E2) and LMHFV in a papain (PP)-induced ex vivo model of IVD degeneration. - Source: PubMed
Publication date: 2026/04/22
Jansen Jan UlrichFigel FelizitasWidmayer FranziskaVogt MortenAhrens MariaWilke Hans-JoachimIgnatius AnitaHaffner-Luntzer MelanieNeidlinger-Wilke CorneliaTeixeira Graciosa Quelhas - Photoaging, primarily induced by prolonged ultraviolet (UV) radiation exposure, significantly alters skin structure and function, necessitating models for deeper understanding and intervention development. This study aims to establish a BALB/c mouse model for investigating photoaging, leveraging their haired skin and genetic consistency. - Source: PubMed
Huynh Cuc BachVu Ngoc BichThe Van TrungVan Pham Phuc - Many biomarkers have been evaluated as potential early detection markers for ovarian cancer. Better understanding of factors associated with inter-individual variation in circulating concentrations of these biomarkers is useful for optimizing their clinical utility for early detection. The study objective was to characterize the associations of sociodemographic-, lifestyle-, and health-related factors in relation to circulating ovarian biomarker concentrations in cancer-free women. - Source: PubMed
Publication date: 2026/04/22
Akonde MaxwellGraybill Whitney SpannuthClay-Gilmour AlyssaZhang JiajiaAlberg Anthony J - The role of P2X7R in promoting inflammation during atherosclerosis is well established; however, the effects of curcumin on P2X7R-related pathways remain poorly understood. This study investigates how curcumin affects P2X7R and related targets like NOX1, MMP-3, and TGF-β in ox-LDL-treated macrophages. THP-1-derived macrophages were exposed to 50 µg/mL oxidized low-density lipoprotein (ox-LDL) for 24 h to induce foam cell formation. Oil Red O staining was employed to confirm lipid accumulation and foam cell development. To investigate the modulatory effects, cells were exposed to P2X7R antagonist (A-438079) (100 µM) and curcumin (20, 40, and 60 µg/ml). The mRNA expression levels of P2RX7, NOX1, MMP-3, and TGF-β was evaluated using quantitative real-time PCR (RT-qPCR). Treatment induced macrophages with curcumin significantly reduced foam cell foemation, in a dose-dependent manner (P < 0.01). The mRNA expression levels of P2RX7, NOX1, MMP-3, and TGF-β were markedly upregulated in ox-LDL-treated macrophages compared to control, but significantly downregulated after treatment with curcumin (P < 0.05, P < 0.01). Similarly, treatment with selective P2X7R antagonist reduced foam cell foemation and suppressed the expression of NOX1, MMP-3, and TGF-β, thereby confirming the critical role of P2X7R in the atherogenic process development. Collectively, The present study demonstrates that curcumin exerts its anti-atherosclerotic effects primarily by inhibiting the P2X7R-mediated inflammatory pathway in ox-LDL-treated macrophages. These findings underscore curcumin's promising therapeutic potential as a natural agent for the prevention and treatment of atherosclerosis, warranting further investigation in preclinical and clinical settings. - Source: PubMed
Publication date: 2026/04/21
Samemaleki SaharAsghariazar VahidMoosavi Zenooz AliTeymuri AlirezaEterafi MajidMoini Jazani ArezooArabzadeh AmirAhmadSafarzadeh Elham