Ask about this productRelated genes to: ICAM1 antibody
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 antibody
Related articles to: ICAM1 antibody
- Diabetic retinopathy is a major microvascular complication of diabetes mellitus. Inflammatory and fibrotic pathways, mediated by intercellular adhesion molecule 1 and transforming growth factor beta 1, play crucial roles in its pathogenesis. - Source: PubMed
Publication date: 2026/07/18
Garg RainaSrivastava TejalWaris AbdulShafiq Siddiqi Sheelu - Thrombosis, a major underlying cause of cardiovascular disorders, is frequently initiated by endothelial cell (EC) activation, which facilitates platelet adhesion and subsequent clot formation. Although vascular injury is a well-established trigger, accumulating evidence implicates hypoxia as an additional determinant of thrombus development. In our previous study, we demonstrated that hypoxia associated with high altitude can promote autophagy-induced platelet aggregation. However, the contribution of ECs to such thrombosis under comparable hypoxic conditions (10%) remains poorly understood. In this study, using ECs isolated from rat aorta , we show that hypoxia-inducible factor-1 alpha (HIF-1α), a key transcription factor, regulates autophagy and subsequent EC activation. Importantly, pharmacological inhibition of HIF-1α-mediated autophagy, repositioning the FDA-approved drug chloroquine (CQ), led to attenuated expression of P-Selectin, ICAM1, VCAM1 and consequent reduced platelet adhesion to ECs. Further mechanistic analysis revealed that autophagy modulates the NF-κB signaling pathway, in which P65 transcriptionally regulates the adhesion molecules ICAM1 and VCAM1 by binding to their upstream promoter elements under hypoxic conditions. In addition, using a rat IVC ligation model, we found that CQ not only attenuates thrombus formation but also suppresses VCAM1 expression, validating its antithrombotic potential. In summary, our findings suggest that hypoxia-induced HIF-1α activation promotes an autophagy-dependent NF-κB signaling cascade, thereby contributing to endothelial activation and thrombus formation. Furthermore, CQ's ability to disrupt this pathway underscores the therapeutic potential of targeting endothelial autophagy to mitigate hypoxia-associated thrombosis. - Source: PubMed
Publication date: 2026/07/29
Bandyopadhyay PropannaKumbhar Pragati RameshKatakia Yash TMajumder SyamantakMukherjee SudeshnaSinghvi GautamChowdhury Rajdeep - Conventional therapies for inflammatory bowel disease (IBD) are associated with significant adverse effects, highlighting the need for safer and effective alternatives. Krill oil (KO), a rich source of long-chain omega-3 polyunsaturated fatty acids (PUFAs) and astaxanthin, has shown therapeutic potential in several disorders but remains understudied in chronic colitis. This study evaluates the potential therapeutic efficacy of KO, alone or in combination with dexamethasone (DEX), in a spontaneous chronic colitis mouse model that closely mimics human IBD. The molecular mechanisms underlying the health benefits of KO were also explored. - Source: PubMed
Publication date: 2026/08/04
Liu YingyingRobinson Ainsley MNurgali KulmiraSu Xiao Qun - Postoperative Delirium (POD) is a common, mechanistically heterogeneous neuropsychiatric syndrome characterized by acute neuroinflammation and neurovascular dysfunction. Despite its clinical significance, the lack of accessible biomarkers to monitor Central Nervous System (CNS) vulnerability remains a major barrier to effective risk stratification. The retina, as an embryological extension of the CNS, shares highly conserved neurovascular and immune architectures with the brain, including blood-barrier parallels and glial-mediated neurovascular coupling. This biological continuity suggests that retinal structure and microvasculature can serve as a noninvasive "proxy" for cerebral health. Recent single-cell and multiomic atlases have identified overlapping cellular programs in the retina and brain involving complement activation, endothelial activation (e.g., ICAM1, MMP9), and innate immune reprogramming. Furthermore, retinal circadian pathways via intrinsically photosensitive retinal ganglion cells (ipRGCs) provide a direct link to the sleep-wake instability observed in POD. Emerging clinical data demonstrate that preexisting Retinal Nerve Fibre Layer (RNFL) thinning is associated with increased delirium risk, reflecting a lower "neural reserve" to withstand perioperative stress. Handheld Optical Coherence Tomography (OCT) studies further confirm the feasibility of bedside retinal imaging in frail surgical populations, such as hip fracture patients. This review synthesizes these strands into an integrated "Retina-Brain Axis" model. We argue that combining retinal phenotyping with EEG and omics data is not only scientifically justified but also clinically necessary to transition from generic care to precision-based, mechanistically guided POD prevention and monitoring. - Source: PubMed
Publication date: 2026/07/31
Huang WeibinTan MengquanFang MuxuanHe XinranZhou HuixianWei XiaoweiXie QinLiu ShengtaoWang TongSong SiyuanDai Yaling - Acute kidney injury (AKI) is a common clinical syndrome associated with high morbidity and progression to chronic kidney disease. Ischaemia is a leading cause of AKI, driving cellular stress, metabolic reprogramming, and injury-associated epithelial states. Scalable human models that enable controlled investigation of ischaemic injury, repair, and therapeutic targets in AKI remain limited. We therefore assessed the extent to which induced pluripotent stem cell (iPSC)-derived human kidney organoids recapitulate key features of ischaemic AKI. - Source: PubMed
Publication date: 2026/08/19
Nunez-Nescolarde Ana BLiao YangPerlaza-Jiménez LauraPiran MehranCheng ZhengqiBarlow Chris KSteele Joel RDeveson DeannaMoreau Julie L MLee Han-ChungLi JinhuaSchittenhelm Ralf BWells Christine AShi WeiNikolic-Paterson David JCombes Alexander N