Ask about this productRelated genes to: ICAM1 antibody
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: ICAM1 antibody
Related articles to: ICAM1 antibody
- Delayed graft function after kidney transplant is associated with increased acute rejection rates and poorer long-term outcomes. It is significantly more prevalent in recipients of deceased than living donor kidneys due to increased ischemia-reperfusion injury associated with prolonged warm and cold ischemic times. Although specific immune populations are associated with ischemia-reperfusion injury and delayed graft function, the precise cellular circuits distinguishing deceased from living donor transplants, as well as the donor and recipient-derived immune programs involved in early immunological responses, have not been defined at cellular resolution. - Source: PubMed
Publication date: 2026/09/22
Mak Martin LMurphy Julia MMathews Jessica ASu ShenghuiKonvalinka AnaEpelman SlavaCrome Sarah Q - Breast cancer metastasis remains the leading cause of disease-related mortality, yet the molecular mechanisms enabling tumor cells to survive circulation and colonize distant organs are incompletely understood. AHNAK, a large scaffold protein implicated in cytoskeletal organization and membrane dynamics, has been reported to exert context-dependent roles in cancer progression, but its contribution to metastatic traits in less aggressive breast cancer cells and under biomechanical stress remains unclear. In this study, we investigated AHNAK expression and function across breast cancer cell models, with a particular focus on its role in modulating cellular mechanics, adhesion, and survival under fluid shear stress (FSS). We first compared AHNAK expression in MDA-MB-231, MDA-MB-231-Br, MCF-7 wild-type, and AHNAK-overexpressing MCF-7 cells, revealing differential expression patterns. Functional analyses demonstrated that AHNAK overexpression in MCF-7 cells did not significantly alter migratory behavior or morphology but increased cellular stiffness, as measured by atomic force microscopy, and increased clonogenic capacity. Conversely, AHNAK knockdown led to increased clonogenic capacity in MDA-MB-231 cells, indicating that the functional effects of AHNAK may vary according to the molecular and phenotypic characteristics of breast cancer cells. AHNAK overexpression also enhanced adhesion of MCF-7 cells to human brain microvascular endothelial cells as well as elevated ICAM-1 expression. Using an in vitro circulation model, we further show that exposure to physiologically relevant levels of FSS reduced overall cell survival; however, AHNAK-overexpressing cells consistently displayed a trend toward increased resistance to shear-induced cell death, with significant changes in post-flow adhesion to endothelial cells. Collectively, these findings indicate that AHNAK exerts cell-type-dependent effects on breast cancer cell phenotypes, promoting increased cellular stiffness, endothelial adhesion, and shear resistance in MCF-7 cells, while its depletion enhances clonogenic capacity in MDA-MB-231 cells. These findings underscore the importance of cellular context when considering the contribution of AHNAK to breast cancer progression and metastatic traits. - Source: PubMed
Publication date: 2026/09/19
Villarinho NicolasNajophe Sarah ETeles Ramon GYamagata Ana Sde Oliveira Jennifer NAzevedo Lais Fde Souza Samuel TMarques Aldilane LBorbely Alexandre UJaeger Ruy GFreitas Vanessa M - Brazilian green propolis is notable for its ability to modulate immune cells. In preeclampsia (PE), endothelial dysfunction is caused by the release of damage-associated molecular patterns, oxidative stress, elevated pro-inflammatory cytokines, and adhesion molecules. This study aimed to evaluate the effects of propolis on biomarkers of endothelial dysfunction and oxidative stress using human umbilical vein endothelial cells (HUVECs). - Source: PubMed
Ribeiro-Vasques Vanessa RochaRomao-Veiga MarianaNunes Priscila RezeckPasseti Luis Fernando PereiraFranco Gabriela de OliveiraBraga da Silva Patriciade Oliveira Larissa Ragozo CardosoPeracoli Jose CarlosPeracoli Maria Terezinha SerraoSforcin Jose Mauricio - Tissue edema results from excessive interstitial fluid accumulation driven by inflammatory responses and increased vascular leakage. This study investigated the protective effects of HY7801 (HY7801) against inflammatory activation, endothelial barrier dysfunction, and edema formation and . In lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, HY7801 reduced nitrite accumulation and expression. In tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVECs), HY7801 increased nitrite accumulation and expression, suppressed the expression of endothelial adhesion molecules (, , and ) and , and enhanced the expression of the tight junction-associated genes ( and ). Furthermore, HY7801 partially restored transendothelial electrical resistance (TEER), an indicator of endothelial barrier integrity, following TNF-α-induced impairment. In a λ-carrageenan-induced mouse paw edema model, HY7801 treatment attenuated paw swelling, histological tissue thickening, and vascular leakage. These effects were accompanied by increased junction-associated gene expression in inflamed paw tissue and reduced circulating inflammatory mediators. Based on these anti-inflammatory and endothelial barrier-protective effects, HY7801-derived extracellular vesicles (HY7801 EVs) were further evaluated as a candidate bioactive component of HY7801. HY7801 EVs enhanced and expression while suppressing , , and expression. Collectively, our findings suggest that HY7801 attenuates inflammation-associated tissue edema and vascular leakage through coordinated modulation of inflammatory and endothelial barrier responses, and support a potential role for HY7801 EVs as a bioactive component contributing to these effects. - Source: PubMed
Publication date: 2026/09/18
Lee DaehyeopJeong HaerynGwon HyeonjunBaik JiminKim Joo-YunShim Jae-JungLee Jae-Hwan - Many studies have focused on identifying specific biomarkers for the early diagnosis of non-traumatic osteonecrosis of the femoral head (NONFH). This systematic review aims to summarize biomarkers associated with the diagnosis and progression prediction of NONFH, thereby providing a molecular level foundation for clinical diagnosis and targeted treatment. - Source: PubMed
Publication date: 2026/09/21
Dong YaweiSun JigaoLi ShuwenZhang JiawenYan YanLi TaixianJia Yan