Ask about this productRelated genes to: CD44 antibody
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
Related products to: CD44 antibody
Related articles to: CD44 antibody
- Although roles of CD44 in the genetic predisposition for bronchopulmonary dysplasia (BPD) has been recognized, the immune characteristics of CD44+ monocytes in BPD are unclear. We aimed to (1) compare the expression and function of CD44 on monocytes in BPD and non-BPD infants; (2) explore the roles of CD44 on monocytes in hyperoxia-induced inflammation. - Source: PubMed
Publication date: 2026/05/02
He YiZhou YingzhiLiu QingqingWang Nianrong - Leukemic stem cells (LSCs) are the cellular reservoir most strongly implicated in relapse of acute myeloid leukemia, yet their operational detection by multiparameter flow cytometry remains challenging because of immunophenotypic overlap with normal progenitors and variability across assays. Including CD45RA in the CD34⁺CD38⁻ gating strategy substantially improves discrimination between malignant and normal stem/progenitor populations and thus enables more precise LSC enumeration in a single-tube format. Given the clinical importance of accurately quantifying the LSC compartment, we evaluated a refined single-tube flow cytometry assay that incorporates CD45RA within the CD34 + CD38- gate to increase specificity for the leukemic stem compartment. - Source: PubMed
Publication date: 2026/05/02
Navidinia Amir AbbasRostami ShahrbanooKarami NajibeShemshadinia MohammadrezaPatekhor Habibeh SabriHajaliaskari AkramMohammadi SaeedRostami TaherehBarkhordar MaryamVaezi MohammadJanbabaei GhasemChahardouli Bahram - Sheep feeding systems strongly influence meat quality, animal health, and production efficiency. Grazing improves fatty acid composition and sustainability but limits productivity, whereas concentrate feeding enhances efficiency but may induce oxidative stress. Vitamin E (VE), a key antioxidant, may mitigate these effects; however, systematic multi-tissue molecular evidence remains limited. - Source: PubMed
Publication date: 2026/04/24
Xu HaoranShi Jie - Breast cancer remains one of the most prevalent malignancies among women worldwide, and despite advances in therapy and treatment options, tumour relapse and metastasis remain major clinical challenges, largely driven by the breast cancer stem cells (BCSCs) niche that resists conventional treatments and regenerates tumours. In breast cancer, where approximately 30% of patients who initially respond to treatment ultimately relapse and die of metastatic disease, targeting BCSCs is critical for improving patient outcomes. Cyclin-dependent kinase inhibitor 1A/p21 (CDKN1A/p21) is a multifunctional protein that is known primarily for its role in regulating the cell cycle in response to DNA damage. However, in this study, we aimed to explore the role of CDKN1A/p21 in the survival and expansion of BCSCs. - Source: PubMed
Publication date: 2026/04/22
Manousakis EvangelosMoreta-Moraleda CristinaMiralles Clàudia MartinezTomàs Pujolà AnnaBaccara HoudaFranquet Laia LiñánMontañés Albó MontserratFerrari RobertoWright Roni H G - Durable CD4 T cell memory is essential against mycobacterial infection, yet activation-induced cell death (AICD) limits the survival of activated clones after BCG vaccination. The upstream, cell-intrinsic brakes that govern this bottleneck remain incompletely defined. Combining transcriptomics, loss-of-function tests, and engineering, we identify as a pro-apoptotic regulator that is downregulated in memory CD4 T cells and promotes activation-induced death in T cell models. We develop an activation-gated AAV platform in which an NFAT-IL-2 promoter drives Cre to flip a FLEXed U6-shRNA cassette, and package them into a single AIO vector. This design confines silencing to antigen-experienced T cells, preferentially within the CD4CD44 compartment. In BCG-vaccinated mice, transient activation-linked inhibition expands CD4 T cells, enhances IL-2 and Th1-skewed recall responses, lowers pulmonary, and splenic bacterial burdens after challenge. These findings highlight a strategy to selectively modulate intrinsic death pathways during immune priming for strengthening vaccine-elicited T cell memory. - Source: PubMed
Publication date: 2026/04/03
Liu ZixuanLiu WeihuangZhao ChenyuBai XuanchangZhou FangtingSun HangShi JiaheChen PinruLiu MinPan Qin