Ask about this productRelated genes to: VCAM1 antibody
- Gene:
- VCAM1 NIH gene
- Name:
- vascular cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- CD106
- Chromosome:
- 1p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2016-10-05
Related products to: VCAM1 antibody
Related articles to: VCAM1 antibody
- This investigation reports the effects of CQPC03 (LP-CQPC03) on preventing thrombus formation and reducing intestinal oxidative stress and inflammation in a carrageenan-induced mouse thrombosis model. High-throughput 16S rRNA sequencing determined the composition of intestinal microorganisms. Biochemical reagents, section observations, and quantitative polymerase chain reaction (qPCR) identified mouse serum and tissue-related markers. Experimental findings show that LP-CQPC03 enhances activated partial thromboplastin time (APTT) and decreases thrombin time (TT), fibrinogen (FIB), and prothrombin time (PT). LP-CQPC03 also significantly reduces black tail severity in thrombotic mice. Moreover, LP-CQPC03 lowers malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), nuclear factor kappa-B (NF-κB), and interleukin-1 beta (IL-1β) levels in thrombotic mouse serum, while increasing superoxide dismutase (SOD) and catalase (CAT) activities. Hematoxylin and eosin (H&E) pathological analysis reveals that LP-CQPC03 lessens tissue damage caused by tail vein thrombosis. In the colon tissues of thrombotic mice, LP-CQPC03 up-regulates the mRNA expression of copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), and CAT, while down-regulating NF-κB p65, IL-6, TNF-α, and interferon gamma (IFN-γ). In tail vein vascular tissues, LP-CQPC03 also suppresses the mRNA expression of NF-κB p65, intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Gut microbiota sequencing results show that LP-CQPC03 increases the population of beneficial bacteria and decreases harmful ones. These findings demonstrate that LP-CQPC03 prevents thrombosis in mice, reduces oxidative stress and intestinal inflammation, and regulates gut microbiota by increasing beneficial bacteria. A high concentration of LP-CQPC03 shows a better effect, comparable to heparin. - Source: PubMed
Publication date: 2026/05/01
Zhao XinWang KejiaChen TianyiMa KaiZhang RongmingOu YonglingKuang Zhiping - Ex vivo lung perfusion (EVLP) is a well-established method for assessing and reconditioning donor lungs before lung transplantation (LTx). Remarkably, clinical outcomes between standard criteria and marginal donor lungs after EVLP are similar despite differences in lung quality. Therefore, we explored several biomarkers during EVLP in this study. Novel findings could guide future interventions to enhance lung quality and expand the donor pool. - Source: PubMed
Publication date: 2026/04/04
Hu M AZhang Z LHoffmann R FGan C TVerschuuren E A MVan De Wauwer CLeuvenink H G DErasmus M E - Integrins and other cell adhesion molecules play a critical role in the migration and homing of leukocytes. This study investigates whether metastatic tumor cells can exploit leukocyte-like rolling and arrest mechanisms during early vascular steps of metastatic dissemination. B16 melanoma cell adhesion to activated bEnd.3 endothelial monolayers or immobilized VCAM-1 were analyzed under defined shear flow using a parallel-plate chamber. Function-blocking antibodies, divalent cation modulation, pertussis toxin, and low-temperature conditions were used as classical controls. B16-BL6 melanoma cells exhibited robust VLA-4-dependent rolling and arrest on activated endothelial monolayers and on immobilized VCAM-1 under physiological shear stresses (0.7-2 dyn/cm), independent of chemokine-related Gαi signaling. These findings identify a chemokine-independent mechanism of VLA-4-mediated vascular capture by melanoma cells under shear flow, providing a potential mechanistic basis for early steps in metastatic dissemination. - Source: PubMed
Publication date: 2026/04/19
Eibl Robert H - Endothelial dysfunction characterized by cytokine release and adhesion molecule upregulation is a major driver of atherogenesis. Tumor necrosis factor-α (TNF-α) activates NF-κB signaling and increases ICAM-1, VCAM-1, IL-6, and IL-8 expression in endothelial cells. This study aimed to investigate whether amentoflavone (AMF) modulates TNF-α-induced inflammatory and adhesion-related responses in human endothelial cells, supporting its potential to mitigate early vascular dysfunction. - Source: PubMed
Publication date: 2026/04/30
Turk Fatih CanOnal BurakCelik ZulalAkkan Ahmet GökhanÖzyazgan Sibel - Protein epigenetic scores (EpiScores) are DNA methylation (DNAm)-based proxies for circulating protein levels and may provide insights into inflammation-cognition relationships. Although some EpiScores have been linked to cognitive decline, it remains unclear whether these proxies show similar associations in other cohorts, and whether their effects vary across distinct cognitive domains. We aimed to evaluate the associations between inflammatory proteins EpiScores and cognitive functions including specific domains in the Swedish Adoption/Twin Study of Aging (SATSA) cohort. We analyzed 1332 repeated measurements from 520 SATSA participants across up to six testing waves (1992-2014). Inflammatory protein EpiScores (N = 27) were generated using previously published CpG site-specific weights. Outcomes were a global cognitive function (GCF) score and four specific cognitive domains (verbal ability, spatial ability, memory, and perceptual speed). We applied marginal linear models within the generalized estimating equations (GEE) framework to estimate population-averaged longitudinal associations, controlling the false discovery rate (FDR) using the Benjamini-Hochberg (BH) procedure (q < 0.05 considered significant). Two EpiScores-C-X-C motif chemokine ligand 9 (CXCL9) and vascular cell adhesion molecule 1 (VCAM1)-showed significant positive associations with GCF. In domain-specific outcomes, VCAM1 demonstrated a positive association with spatial ability, whereas C-X-C motif chemokine ligand 11 (CXCL11) had a negative association with verbal ability. These associations were broadly consistent across multiple sensitivity analyses. Inflammation-related DNAm signatures of certain proteins were associated with cognitive performance in SATSA samples. Moreover, the associations differ by cognitive domain. Future longitudinal studies are warranted to clarify the causal implications of these EpiScore-cognition associations and to explore population differences in DNAm patterns. - Source: PubMed
Publication date: 2026/04/30
Ishihara KazuyukiHägg SaraLopes De Oliveira Thaís