Ask about this productRelated genes to: MSRA antibody
- Gene:
- MSRA NIH gene
- Name:
- methionine sulfoxide reductase A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2015-08-25
Related products to: MSRA antibody
Related articles to: MSRA antibody
- The Multi-Specialty Recruitment Assessment (MSRA) is a national aptitude test increasingly incorporated into selection for Core Surgical Training (CST) in the United Kingdom. Although intended to enhance objectivity and equity, its relationship with subsequent interview performance and final CST offer outcomes remains unexplored. - Source: PubMed
Publication date: 2026/04/14
Seehra J KEllis RDoleman BMcLarty ELund J N - - Source: PubMed
Publication date: 2026/04/14
Ahmad AmaaniOruganti SameeraLadan ZahraZhang Nicole YWilloughby LouiseYousaf FatimaKarunakaran VithushiSayegh SourayaHadjicharalambous CharalambosGlanville JamesCastelino MadhuraFisher CorinneLeandro MariaReddy Venkat RSen Debajit - Acute kidney injury (AKI), whether induced by nephrotoxins like glycerol or by gamma radiation, is characterized by severe oxidative stress and subsequent mitochondrial dysfunction. We investigated the protective mechanism of sodium propionate (SP) against AKI in a rat model. Six experimental groups were established: (I) control rats were given saline; (II) rats were administered SP (37.5 mg/kg, p.o.) for two weeks; (III) rats were given an intramuscular injection of glycerol 10 mL/kg body weight; (IV) rats were given glycerol followed by SP treatment for two weeks; (V) rats were exposed to fractionated gamma-radiation (8 Gy; delivered as 2 Gy x 4 times); and (VI) γ-irradiated rats were treated with SP for two weeks. In comparison to AKI rats, SP treatment significantly preserved renal function, reduced serum urea and creatinine, and improved histopathological features. Biochemically, SP reduced lipid peroxidation and protein oxidation (malondialdehyde MDA, protein carbonyl PC, and lipofuscin) while restoring antioxidant defenses as reduced glutathione (GSH) and methionine sulfoxide reductase A (MSRA). SP restored mitophagy flux by increasing microtubule-associated protein light chain 3 (LC3II/LC3I) ratio and PTEN-induced putative kinase 1 (PINK-1) levels, promoting p62 clearance, and downregulating the mitochondrial stress marker, activating transcription factor 5 (ATF5), relative to the untreated AKI groups. These findings demonstrate that SP confers protection against AKI by attenuating oxidative stress and re-establishing mitochondrial quality control through re-establishment of autophagic flux. Hence, SP represents a promising candidate for therapeutic intervention in nephrotoxin- and γ-radiation-induced renal injury. - Source: PubMed
Publication date: 2026/04/12
Habieb Mahmoud EAli Maha MAbd-ElRaouf AmiraAbdou Fatma Y - Antimicrobial resistance (AMR) in natural environments and wildlife is an escalating threat to global health and biodiversity conservation. Neotropical primates of the genus Sapajus may act as reservoirs and ecological sentinels of resistant bacteria. The absence of systematic microbiological screening in wildlife rehabilitation centers, coupled with empirical antimicrobial use, can facilitate resistance spread in vulnerable ecosystems. This study characterized phenotypic and genotypic resistance profiles and biofilm-forming ability of Staphylococcus spp. and Mammaliicoccus sciuri isolated from Sapajus libidinosus undergoing rehabilitation in Northeastern Brazil. Rectal swabs were collected, and bacterial isolates identified by MALDI-TOF MS, followed by antimicrobial susceptibility testing, molecular detection of resistance genes, and biofilm assays. Nineteen isolates were recovered: 63.2% Staphylococcus spp. and 36.8% Mammaliicoccus spp. The predominant species were M. sciuri (36.8%) and S. simiae (31.6%). Rates of resistance to penicillin (63.2%) and tetracycline (57.9%) were the most frequent. The main resistance genes detected included tetM (36.8%), tet(38) (31.6%), blaZ (26.3%), msrA (26.3%), and mecA (5.3%). Perfect agreement existed between mecA presence and cefoxitin resistance (κ = 1.00; p < 0.01), with moderate agreement between msrA and non-susceptibility to erythromycin and clindamycin (j= 0.56; p = 0.0265). Biofilm production was mostly weak (94.7%), with moderate production in one isolate. Multidrug resistance occurred in 21.1% of isolates. This pioneering Brazilian study highlights wildlife rehabilitation centers as critical hotspots for AMR surveillance and contributes to understanding the ecological health and conservation of Neotropical primates. - Source: PubMed
Publication date: 2026/04/06
de Leite Denny Parente Sá Barreto Maiade Pinto Gustavo Oliveira Alvesda Silva Maria Eduarda Uchôa Cavalcanti Moreirada Silva Valdir VieiraGoncalves Lucilene Martins Trindadede Albuquerque Maria Clara FeitosaSantos Rafaela Silvada Silva Luana Thamires RapôsoValença Yuri MarinhoBeraldo Karolina Rosa FernandesJuliano Maria Aparecidade Oliveira Pollyanne Raysa Fernandesda Silva José GivanildoMota Rinaldo Aparecido - The escalating prevalence of antimicrobial resistance in food-related pathogens constitutes a critical challenge to global public health and food safety. To elucidate the mechanisms underlying the high erythromycin resistance rate observed in our previous surveillance of Staphylococcus in retail foods, we conducted a comprehensive genomic investigation of msrA-positive Staphylococcus from a nationwide retail food collection in China. We identified 102 msrA-positive isolates, all of which exhibited a multidrug-resistant (MDR) phenotype, with a significantly higher prevalence in aquatic products (13.95%), identifying this food category as a high-risk reservoir for transmitting resistant bacteria to consumers. Genomic typing revealed the dominance of the S. aureus ST15-t085 lineage (58.0%), which exhibited a specific ecological adaptation to retail aquatic products. We characterized 12 novel msrA-harboring plasmids (pMsrA-I to pMsrA-XII), with the dominant Type A plasmids carrying a coupled msrA-mphC cassette that confers synergistic high-level resistance. Structural analysis demonstrated that IS431R serves as a key driver of plasmid evolution, mediating the capture of resistance clusters. Notably, these plasmids also harbor genes conferring tolerance to heavy metals and food preservatives, physically linked to the antimicrobial resistance regions. This genetic linkage suggests that routine disinfection and environmental residues in retail food processing environments likely drive the co-selection of these multidrug-resistant plasmids. Furthermore, these isolates harbored both the plasmids and chromosomal biofilm-associated genes, as well as the neglected enterotoxin gene seh (15.7%), highlights a dual threat of environmental persistence and pathogenicity. These findings underscore the urgent need for targeted surveillance of novel resistance plasmids in the retail food market to mitigate the spread of these multidrug-resistant pathogens. - Source: PubMed
Publication date: 2026/03/31
Zhang FengMa ShiyuGao JiaxuPei XiaodongYang XuZhang ZhipingSong LiliWei Tao