Ask about this productRelated genes to: MSRA antibody
- Gene:
- MSRA NIH gene
- Name:
- methionine sulfoxide reductase A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2015-08-25
Related products to: MSRA antibody
Related articles to: MSRA antibody
- Multidrug efflux systems (MESs) are major contributors to antimicrobial resistance (AMR) in , yet their role in primary healthcare settings is poorly understood. Under a One Health framework, we investigated MES-mediated resistance in 38 isolates (27 from humans, 11 from dogs) from three Basic Health Units (BHUs) in Viçosa, Brazil. Isolates were characterized by antimicrobial susceptibility testing, PCR for six key efflux genes, and (GTG)-PCR fingerprinting. Phenotypic efflux activity was evaluated using ethidium bromide fluorescence assays. Thirty-seven isolates were resistant to at least one antimicrobial, most commonly penicillin (57.9%) and erythromycin (55.3%), while all remained susceptible to chloramphenicol, trimethoprim, and linezolid. While the gene was rare (10.5%), other efflux genes like , , and were nearly ubiquitous (> 94%). This high genetic prevalence contrasted with low phenotypic resistance, indicating that most MES genes were not expressed. Fingerprinting revealed seven genetic clusters, demonstrating the circulation of closely related strains between human and animal hosts across different health units. Eight isolates showed clear genotype-phenotype concordance, with MES activity confirmed phenotypically. The four -positive, erythromycin-intermediate isolates formed two clonal groups (100% similarity): one shared between two users from different BHUs and another shared between a healthcare worker and a dog from different BHUs, providing direct evidence of interhost and cross-geographic AMR dissemination. Moreover, co-colonization of a single individual with two genetically distinct tetracycline-resistant strains (60% similarity) suggests possible horizontal gene transfer. Although phenotypic MES-mediated resistance was limited (21%), we demonstrate the potential AMR spread across hosts and geographic boundaries, as primary healthcare settings harbor a significant reservoir of MES genes in even if they are silent. These results highlight the critical need for integrated One Health surveillance in community settings to mitigate AMR dissemination. - Source: PubMed
Publication date: 2026/05/14
Lopes Ilderlane da SilvaMoreira Ana Júlia Silvade Barros MarianaBueno Leonardo Moises Salesda Silva Giarlã CunhaRosa Jéssica NogueiraCaldeira Jéssica Lobo AlbuquerqueBarros Rodrigo AlvesBazzolli Denise Mara SoaresMoreira Maria Aparecida Scatamburlo - Among all known repair enzymes, methionine sulfoxide reductase A (MsrA) plays a key role in protecting against oxidative stress and its damaging effects. The enzyme is ubiquitously expressed in eukaryotic cells and different splice variants of the MsrA gene have been shown to permit the specific prevalence of the protein in different cell organelles. Here, we present novel insights in the intracellular localization of MsrA in selected samples from mouse and human tissue. Using immunocytochemical techniques at both the light and electron microscopic levels, we show incidence of MsrA in human oral mucosa cells, predominantly in the cell nucleus. In addition, the enzyme has been localized in mitochondria of mouse liver and kidney cells, in the cytoplasm of retina cells, and in the endoplasmic reticulum of glandular cells. Overall, the results indicate a correlation between the generation of reactive oxygen species (ROS) and the expression level of MsrA in subcellular compartments of the tissues examined. - Source: PubMed
Publication date: 2026/05/18
Agricola HansLesser ThomasWetzker Reinhard - The study objective was to assess occupational exposure to bacteria and antimicrobial resistance genes (ARGs) present on air filters of utility vehicles used in the working environment of mechanical-biological treatment (MBT) facilities, in the context of workers health risks. - Source: PubMed
Publication date: 2026/05/14
Kozajda AnnaMiśkiewicz EmiliaGawor JanGromadka Robert - The Multi-Specialty Recruitment Assessment (MSRA) is a proctored assessment, comprising a clinical problem-solving (CPS) test and a situational judgement test (SJT), often combined with selection interviews, for admission to multiple postgraduate medical specialty training programmes in the UK. The study examined the predictive validity of these selection assessments (i.e. the extent to which they effectively predicted later performance outcomes). - Source: PubMed
Publication date: 2026/05/13
Morley EmmaWoods Stephen ABaron HelenPatterson Fiona - species, particularly , are leading opportunistic pathogens responsible for a wide range of infections, with antimicrobial resistance-including high rates of macrolide resistance-severely limiting treatment options. The gene encodes the ABC-F protein MsrA, which mediates inducible resistance to 14-membered macrolides and type B streptogramins. Despite its clinical and epidemiological relevance, the evolutionary forces, selective pressures, and transmission routes shaping in staphylococci remain insufficiently understood. - Source: PubMed
Publication date: 2026/04/22
Janelidze DavitKobakhidze SabaElbakidze TinatinKotetishvili Mamuka