Ask about this productRelated genes to: MSRA antibody
- Gene:
- MSRA NIH gene
- Name:
- methionine sulfoxide reductase A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2015-08-25
Related products to: MSRA antibody
Related articles to: MSRA antibody
- The Professional Dilemmas (PD) paper of the UK Multi-Specialty Recruitment Assessment (MSRA) is a situational judgement test (SJT) used to shortlist candidates for several postgraduate specialty training programmes, including general practice, core psychiatry, clinical radiology and obstetrics and gynaecology. Candidates increasingly use publicly available large language models (LLMs) informally during examination preparation, yet the performance of contemporary LLMs on this examination has not been established. This study aimed to quantify and compare the performance of six publicly available LLMs on the official MSRA practice paper. - Source: PubMed
Publication date: 2026/08/28
Ahmed Mohammad JakirMansoor Munsif MMahmood Hamza AEbrahim Rawan S - is a major foodborne pathogen of public health concern because of the severe outcomes associated with invasive listeriosis, its ability to persist throughout the food chain, and its capacity to form biofilms. In this study, the occurrence, antimicrobial resistance, antimicrobial resistance genes, and biofilm-forming capacity of from food of animal origin in Northern Kazakhstan were investigated, and the association between the biofilm phenotype and antimicrobial resistance was also assessed. A total of 1561 samples were analyzed. was isolated and identified according to ISO 11290-1 and confirmed by MALDI-TOF MS. Antimicrobial susceptibility was determined by disk diffusion according to EUCAST recommendations. Resistance genes were detected by PCR, and biofilm formation was assessed using a crystal violet assay. was detected in 34 (2.18%) samples. Resistance to at least one antimicrobial agent was observed in 18 (52.9%) isolates, with the highest resistance rate observed for trimethoprim-sulfamethoxazole (14/34, 41.2%). Multidrug resistance was detected in 8 (23.5%) isolates and was defined as resistance to at least three antimicrobial classes, including β-lactams, macrolides, and sulfonamides. The most frequently detected resistance genes were (26.5%) and (20.6%). All isolates formed biofilms, with 44.1% classified as strong producers and 55.9% as moderate producers. Strong biofilm formation was significantly associated with antimicrobial resistance (OR = 4.71, = 0.045). was detected in 34 (2.18%) animal-origin food samples from Northern Kazakhstan. The isolates demonstrated antimicrobial resistance and biofilm-forming capacity, with a significant association between strong biofilm formation and antimicrobial resistance. These findings highlight the importance of continued microbiological surveillance of in animal-origin foods. - Source: PubMed
Publication date: 2026/09/17
Abilova ZulkyyaBalabayev BulatShevchenko PavelYernazarova MadinaBulashev AitbayRychshanova RaushanGabitova Albina - Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological and cachectic settings. Upon adrenergic stimulation of adipocytes, an influx of iron induces the activity of methionine sulfoxide reductase A (MSRA), an enzyme that reverses the oxidation of proteinaceous methionine residues. Mechanistically, iron coordination by the conserved iron-binding EXXH motif of two MSRA polypeptides serves to dimerize, stabilize and elevate its reductase activity. Iron-bound MSRA dimers in turn promote adipose browning by maintaining the reduced state of select substrates, including the catalytic subunit of protein kinase A. Remarkably, in mouse models, MsrA deletion impairs adipose browning, mitigates cachexia and prolongs the survival of tumor-bearing animals. Thus, as a key nexus of cancer-associated cachexia, the β3 adrenergic receptor-iron-MSRA axis is a promising target for clinical intervention. - Source: PubMed
Publication date: 2026/09/22
Nam Jung SeungAhn Sung ShinShin YeonohVargas-Castillo ArianaDixon Maya SAhmadi PardisSchilling KathrinZandkarimi FereshtehChen AlexYoon Nal AeCullen HarrisonSun YanpingCaffrey Thomas CKlute Kelsey ASwanson Benjamin JLu JordanPan SamuelChen YuxuanIchimiya ShuKim GeenaGenkinger Jeanine MSugahara KazukiKluger Michael DGrandgenett PaulHollingsworth Michael ABerchowitz LukeFerrante Anthony WZeltser Lori MDiano SabrinaChio Iok In Christine - - Source: PubMed
Publication date: 2026/09/22
Lim Jun JieScurr Tom - - Source: PubMed
Publication date: 2026/09/15
Afzal Azreen