Ask about this productRelated genes to: MSRA antibody
- Gene:
- MSRA NIH gene
- Name:
- methionine sulfoxide reductase A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2015-08-25
Related products to: MSRA antibody
Related articles to: MSRA antibody
- - Source: PubMed
Publication date: 2026/09/15
Afzal Azreen - Methicillin-resistant (MRSA) poses a significant threat to global healthcare, requiring novel therapeutic strategies. Prophages, latent phage genomes integrated into bacterial chromosomes, are important resources for antimicrobial development due to their genomic stability and genetic engineering potential. - Source: PubMed
Publication date: 2026/08/31
Ran FangfeiYang MingleiZeng XiuxiuSu HuiDong JiayiGao GuoshengHu AirongHu YaorenSun Yuechao - The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, we identify diet-responsive cis-pQTLs and highlight regulatory effects on LBR and MSRA, proteins involved in cholesterol and methionine metabolism respectively. LBR-associated cis-pQTL rs74148404 colocalizes with obesity exclusively under dietary restriction, suggesting diet-dependent modulation of genetic risk. We also show that a diet-dependent cis-pQTL for metabolic regulator FGF21 colocalizes with eosinophil and platelet traits pointing to diet-sensitive immunometabolic signalling. By parallel profiling of a continuously omnivorous control group (N = 211), we uncover seasonally dynamic genetic regulation for proteins linked to apoptosis in immune system pathways (MAVS, CASP3, PDLIM7, IL12RB1), effects likely masked by animal product restriction. These findings reveal dynamic diet- and season-sensitive regulatory mechanisms with implications for precision nutrition and individualized disease prevention strategies, and underscore the need to integrate environmental context into genetic studies of health and disease. - Source: PubMed
Publication date: 2026/08/08
Simistiras AlexandrosBocher OzvanEmmanouil ChristinaSkoulakis AnargyrosGlentis StavrosScarmeas NikolaosZeggini EleftheriaRouskas KonstantinosDimas Antigone S - Resistance to macrolide, lincosamide, and streptogramin B (MLS) antibiotics in has emerged as a significant therapeutic challenge. gene-encoded ribosomal methylation is expressed either constitutively or inducibly, causing resistance to erythromycin and clindamycin with possible induction of clindamycin resistance during therapy. -mediated active drug efflux confers resistance to macrolides and streptogramin B while preserving clindamycin susceptibility. This study aimed to determine the antimicrobial susceptibility pattern of isolates and correlate between the phenotypic and genotypic patterns of clindamycin resistance. - Source: PubMed
Publication date: 2026/08/31
Hans Raechal SanjanaM Suchitra Shenoy - Antimicrobial resistance (AMR) among Staphylococcus and Mammaliicoccus species is a growing concern in wildlife care settings, as rehabilitation centers may represent contact points among wild animals, captive environments, and human handlers. This study characterized antimicrobial resistance profiles, multiple antibiotic resistance (MAR) indices, and biofilm formation in Staphylococcus spp. and Mammaliicoccus sciuri isolated from wild mammals housed at a wildlife screening and rehabilitation center in Pernambuco, northeastern Brazil. Oropharyngeal and rectal swabs were collected from 84 individuals representing 15 species. Isolates were identified using MALDI-TOF MS, and susceptibility to oxacillin, cefoxitin, clindamycin, erythromycin, gentamicin, norfloxacin, and tetracycline was assessed by disk diffusion. Multidrug resistance (MDR) and MAR indices were determined, and the resistance genes mecA, mecC, norA, msrA, tet(38), and tetM were investigated by PCR. Bacterial growth on mannitol salt agar was obtained from samples collected from 63/84 (75.0%) animals, yielding 63 confirmed isolates. Mammaliicoccus sciuri was the most frequently identified species, accounting for 29/63 (46.0%) isolates, followed by Staphylococcus aureus, Staphylococcus felis, and Staphylococcus simulans, with 5/63 (7.9%) isolates each. Overall, 50/63 (79.4%) isolates were resistant to at least one antimicrobial category, and 13/63 (20.6%) were classified as MDR. Resistance was most frequently observed to oxacillin (68.3%), followed by cefoxitin (28.6%), erythromycin (27.0%), tetracycline (25.4%), clindamycin (22.2%), norfloxacin (11.1%), and gentamicin (11.1%). MAR indices ranged from 0.00 to 1.00, with a mean value of 0.28. Resistance genes were detected in a subset of isolates, including mecA (4/63; 6.3%), norA (2/63; 3.2%), and msrA (1/63; 1.6%), whereas mecC, tet(38), and tetM were not detected. Biofilm formation was observed in 33/63 (52.4%) isolates, predominantly among weak and moderate producers. These findings provide baseline evidence supporting systematic microbiological surveillance, antimicrobial stewardship, and biosafety measures in wildlife rehabilitation facilities within a One Health framework. - Source: PubMed
Publication date: 2026/08/26
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