Ask about this productRelated genes to: MSRA antibody
- Gene:
- MSRA NIH gene
- Name:
- methionine sulfoxide reductase A
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2015-08-25
Related products to: MSRA antibody
Related articles to: MSRA antibody
- Adipose browning and atrophy are early events of cachexia, a lethal metabolic disorder affecting nearly half of the population with cancer. Here, using individual-derived specimens and mouse models, we identified an iron-dependent pathway that initiates adipose browning in both physiological and cachectic settings. Upon adrenergic stimulation of adipocytes, an influx of iron induces the activity of methionine sulfoxide reductase A (MSRA), an enzyme that reverses the oxidation of proteinaceous methionine residues. Mechanistically, iron coordination by the conserved iron-binding EXXH motif of two MSRA polypeptides serves to dimerize, stabilize and elevate its reductase activity. Iron-bound MSRA dimers in turn promote adipose browning by maintaining the reduced state of select substrates, including the catalytic subunit of protein kinase A. Remarkably, in mouse models, MsrA deletion impairs adipose browning, mitigates cachexia and prolongs the survival of tumor-bearing animals. Thus, as a key nexus of cancer-associated cachexia, the β3 adrenergic receptor-iron-MSRA axis is a promising target for clinical intervention. - Source: PubMed
Publication date: 2026/09/22
Nam Jung SeungAhn Sung ShinShin YeonohVargas-Castillo ArianaDixon Maya SAhmadi PardisSchilling KathrinZandkarimi FereshtehChen AlexYoon Nal AeCullen HarrisonSun YanpingCaffrey Thomas CKlute Kelsey ASwanson Benjamin JLu JordanPan SamuelChen YuxuanIchimiya ShuKim GeenaGenkinger Jeanine MSugahara KazukiKluger Michael DGrandgenett PaulHollingsworth Michael ABerchowitz LukeFerrante Anthony WZeltser Lori MDiano SabrinaChio Iok In Christine - - Source: PubMed
Publication date: 2026/09/22
Lim Jun JieScurr Tom - - Source: PubMed
Publication date: 2026/09/15
Afzal Azreen - Methicillin-resistant (MRSA) poses a significant threat to global healthcare, requiring novel therapeutic strategies. Prophages, latent phage genomes integrated into bacterial chromosomes, are important resources for antimicrobial development due to their genomic stability and genetic engineering potential. - Source: PubMed
Publication date: 2026/08/31
Ran FangfeiYang MingleiZeng XiuxiuSu HuiDong JiayiGao GuoshengHu AirongHu YaorenSun Yuechao - The effect of diet on genetic regulation in humans remains largely unexplored. Here, we investigate gene-diet interactions in a unique group of healthy individuals (N = 200) who alternate between omnivory and dietary restriction of animal products for religious reasons. Using longitudinal proteomic and genotype data, we identify diet-responsive cis-pQTLs and highlight regulatory effects on LBR and MSRA, proteins involved in cholesterol and methionine metabolism respectively. LBR-associated cis-pQTL rs74148404 colocalizes with obesity exclusively under dietary restriction, suggesting diet-dependent modulation of genetic risk. We also show that a diet-dependent cis-pQTL for metabolic regulator FGF21 colocalizes with eosinophil and platelet traits pointing to diet-sensitive immunometabolic signalling. By parallel profiling of a continuously omnivorous control group (N = 211), we uncover seasonally dynamic genetic regulation for proteins linked to apoptosis in immune system pathways (MAVS, CASP3, PDLIM7, IL12RB1), effects likely masked by animal product restriction. These findings reveal dynamic diet- and season-sensitive regulatory mechanisms with implications for precision nutrition and individualized disease prevention strategies, and underscore the need to integrate environmental context into genetic studies of health and disease. - Source: PubMed
Publication date: 2026/08/08
Simistiras AlexandrosBocher OzvanEmmanouil ChristinaSkoulakis AnargyrosGlentis StavrosScarmeas NikolaosZeggini EleftheriaRouskas KonstantinosDimas Antigone S