Ask about this productRelated genes to: Jak2 antibody
- Gene:
- JAK2 NIH gene
- Name:
- Janus kinase 2
- Previous symbol:
- -
- Synonyms:
- JTK10
- Chromosome:
- 9p24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-04-16
- Date modifiied:
- 2019-04-23
Related products to: Jak2 antibody
Related articles to: Jak2 antibody
- Mutations in cytokine receptor and JAK/STAT; Cy-JAK/STAT) signaling genes drive myeloproliferative neoplasms (MPNs) but remain incompletely characterized in acute myeloid leukemia (AML). The authors evaluated the prevalence, clinical presentation, and prognostic significance of Cy-JAK/STAT pathway mutations in patients with AML and compared outcomes across disease ontogeny. - Source: PubMed
Albliwi MoathNurse Daniel PZabor Emily CHanna JohnEl-Asmar JessicaBawwab AmeedAbuamsha HasanAbu-Farsakh YomnaBatah HeyaRauf AsadNakitandwe JoyBosler David SParthasarathy Prerana BangaloreAlban TylerJain Akriti GMolina John CBalderman SophiaSingh AbhayGerds Aaron TMukherjee SudiptoAdvani Anjali SCarraway Hetty EMustafa Ali Moaath K - Psoriasis is an immune-mediated chronic inflammatory skin disease. Existing therapies have limitations, necessitating the development of new treatment approaches. Compound Baixianpi Formula (FFBXP) is a clinically effective topical Chinese herbal formula, but its material basis and mechanism of action remain unclear. - Source: PubMed
Publication date: 2026/05/22
Tang LinWang YanliZhou YueGan ChunliWang Jinhui - Glioblastoma (GBM) relapse and drug resistance are driven by a subset of quiescent, therapy-tolerant cells that persist in the G0 phase. However, the molecular mechanism coupling immune signaling to tumor cell quiescence and metabolic adaptation remains unclear. - Source: PubMed
Publication date: 2026/05/22
Qian YuZhao Kai - Vascular invasion critically determines intrahepatic and extrahepatic metastasis and early recurrence in hepatocellular carcinoma (HCC), yet its underlying mechanisms remain poorly defined. In this study, we employed EdU proliferation, colony formation, wound healing, transwell, spheroid formation, and immunofluorescence assays, along with xenograft tumor and liver/lung metastasis models, immunohistochemistry, and western blotting to investigate the biological functions of tissue factor (TF) and the therapeutic potential of targeting TF and its downstream signaling. Our results demonstrate that TF is upregulated in HCC tissues and correlates with poor prognosis. TF overexpression significantly enhanced HCC cell proliferation, migration, invasion, and spheroid formation in vitro, and promoted tumor growth and metastasis in vivo. Clinical sample analysis further revealed that high TF expression increases the dissemination potential of circulating tumor cells (CTCs) and circulating tumor microemboli (CTMs) in peripheral blood, thereby facilitating hematogenous spread. Mechanistically, TF activates PAR1 on HCC cell surfaces, leading to activation of both the Wnt/β-catenin and JAK2/STAT3 pathways, with nuclear translocation and accumulation of β-catenin and STAT3. Notably, nuclear STAT3 enhances TF promoter activity, forming a positive feedback loop that sustains downstream signaling. TF also promotes extracellular matrix degradation. Importantly, combined inhibition of TF with β-catenin and STAT3 blockers effectively suppressed HCC tumorigenesis and metastasis both in vitro and in vivo. These findings elucidate the oncogenic role of TF in vascular invasion-mediated HCC metastasis and suggest a promising combinatorial therapeutic strategy for HCC treatment. - Source: PubMed
Publication date: 2026/05/23
Wang Wen-ChaoJi Wei-DanMa Jun-YongPan YunChen LeiLin Xue-JingChen YingTang MinLiu Hai-LongLin Mou-BinZhang Xiao-FengSun Bin - Understanding how molecular architecture dictates the bioactivity of functional oligosaccharides remains a major challenge. Here, mannan oligosaccharides (MOS) were prepared from yeast cell wall mannan, and Gleditsia sinensis Lam. endosperm galactomannan, to investigate structure-function relationships in preventing inflammatory bowel disease. The protective effects of yeast-derived MOS (Y-MOS) and Gleditsia-derived MOS (G-MOS) were comparatively evaluated using a dextran sodium sulfate (DSS)-induced colitis mice model. Structural analysis revealed that Y-MOS primarily consisted of α-1,6 linked mannose with α-1,2/α-1,3 linked side chains, whereas G-MOS featured a β-1,4 linked mannose backbone with α-1,6 linked galactose branches. Furthermore, both MOSs mitigated colitis symptoms, preserved colonic epithelial barrier integrity, and suppressed inflammatory cytokines, primarily through suppressing JAK2-STAT3 and NF-κB signaling pathways, regulating gut microbiota, and promoting short-chain fatty acid production. Notably, G-MOS was more effective than Y-MOS, particularly in immune regulation and modulation of gut microbiota. Molecular docking further revealed that the rigid β-linked conformation of G-MOS exhibited stronger binding affinity toward inflammatory receptors, leading to more effective pathway inhibition, as validated in LPS-treated RAW264.7 cells. These findings elucidate a glycosidic topology-dependent molecular mechanism underlying MOS bioactivity, and identify β-linked G-MOS as a promising, sustainable candidate for inflammation management. - Source: PubMed
Publication date: 2026/05/07
Jin ZiyiBian BinZhang WeiWu QijunChen YananLai ChenhuanYong Qiang