Ask about this productRelated genes to: ZCCHC24 antibody
- Gene:
- ZCCHC24 NIH gene
- Name:
- zinc finger CCHC-type containing 24
- Previous symbol:
- C10orf56
- Synonyms:
- FLJ90798, Z3CXXC8
- Chromosome:
- 10q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-27
- Date modifiied:
- 2016-02-12
Related products to: ZCCHC24 antibody
Related articles to: ZCCHC24 antibody
- The Chinese mitten crab, , is a water-dwelling crustacean that is widely distributed in northern hemisphere water systems. Body size is one of the crucial indicators determining the economic value of . However, research on the genetic basis and regulatory mechanisms of body size in this species is limited, with only a few relevant genes reported. Therefore, it is imperative to investigate the regulatory pathways associated with its growth. This study first utilized transcriptomic profiling and metabolomic sequencing to construct gene expression profiles and metabolite profiles of of different body sizes. Subsequently, through integrated omics analysis, the key genes and regulatory pathways involved in controlling the growth and size of crabs were preliminarily identified. This study found that larger female crabs exhibited significantly enhanced digestive functions, primarily reflected in the upregulation of expression, suggesting its potentially pivotal role in regulating the growth and development of crabs. Interestingly, a variety of tissue-specific proteins such as APOLPP, RICK A, AGMO, and NEPHRIN, as well as REXO1L1P and ZCCHC24, indirectly influence the growth and development of crabs through their respective functional pathways. In addition, the key KEGG pathways, such as ECM-receptor interaction, cell adhesion, and the PI3K-Akt signaling pathway, were revealed to play central roles in the growth regulation of . These findings expand our understanding of the growth regulation mechanisms in crustaceans and offer potential molecular targets for body-size improvement in aquaculture. - Source: PubMed
Publication date: 2025/05/12
Che SiluGao JiancaoZhu HaojunDu JinliangCao LipingZheng YaoXu GangchunLiu Bo - Triple-negative breast cancer (TNBC) lacks the expression of hormone and HER2 receptors and is highly malignant with no effective therapeutic targets. In TNBC, the cancer stem-like cell (CSC) population is considered to be the main cause of resistance to treatment. Thus, the therapeutic targeting of this population could substantially improve patient survival. Here, we identify the RNA-binding protein ZCCHC24 as enriched in the mesenchymal-like TNBC population. ZCCHC24 promotes the expression of a set of genes related to tumorigenicity and treatment resistance by directly binding to the cis-element "UGUWHWWA" in their mRNAs, thereby stabilizing them. One of the ZCCHC24 targets, ZEB1, is a transcription factor that promotes the expression of cancer stemness genes and reciprocally induces ZCCHC24 expression. ZCCHC24 knockdown by siRNAs shows a therapeutic effect and reduces the mesenchymal-like cell population in TNBC patient-derived xenografts. ZCCHC24 knockdown also has additive effects with the BET inhibitor JQ1 in suppressing tumor growth in TNBC patient-derived xenografts. - Source: PubMed
Publication date: 2024/10/17
Uchida YutaroKurimoto RyotaChiba TomokiMatsushima TakahideOda GoshiOnishi IichirohTakeuchi YasutoGotoh NorikoAsahara Hiroshi - The cell endocrine pathway is a critical physiological process composed of the endoplasmic reticulum, Golgi apparatus and associated vesicles. Loss of enzymes or proteins can cause dysfunction of endoplasmic reticulum and Golgi apparatus and affect secretion pathways leading to a variety of human diseases, including cancer. - Source: PubMed
Yu DanLuo YanGuo RongMa FangChang YunyunDang Jianhong - Di (2-ethylhexyl) phthalate (DEHP) is a common plasticizer known to cause liver injury. Green tea is reported to exert therapeutic effects on heavy metal exposure-induced organ damage. However, limited studies have examined the therapeutic effects of green tea polyphenols (GTPs) on DEHP-induced liver damage. - Source: PubMed
Shi HengZhao Xin-HaiPeng QinZhou Xian-LingLiu Si-SiSun Chuan-ChuanCao Qiu-YuZhu Shi-PingSun Sheng-Yun - Globally, liver cancer is one of the most common malignant tumors and is the third leading cause of cancer deaths. RNA-binding protein (RBP) is a general term for a class of proteins that bind to RNA to regulate metabolic processes. The expression of RNA-binding proteins is related to the prognosis of liver cancer patients. - Source: PubMed
Apizi AnwaierWang LinWusiman LaibijiangSong ErchuHan YipengJia TengfeiZhang Wenbin