Ask about this productRelated genes to: VASP antibody
- Gene:
- VASP NIH gene
- Name:
- vasodilator stimulated phosphoprotein
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-07
- Date modifiied:
- 2017-06-13
Related products to: VASP antibody
Related articles to: VASP antibody
- Using glycine as a model system, this study examines the surface assisted reaction between methylamine and formic acid on an olivine (010) surface. A comparative analysis of co-adsorbed, mixed phase, and gas phase pathways of methyl amine and formic acid to form glycine shows that a surface assisted pathway exists that connects adsorbed formic acid and methylamine to a surface stabilized glycine configuration with significantly reduced reaction energetics relative to gas phase, suggesting a plausible role for silicate minerals in facilitating complex organic synthesis under astro-physically relevant conditions. - Source: PubMed
Publication date: 2026/05/07
Asaduzzaman Abu - As a novel type of high-energy-density, environmentally friendly, and low-sensitivity energetic materials (EMs), cyclo-pentazolate salts are being extensively studied. However, their detonation mechanism remains unclear. This study developed a neural network potential (NNP) to simulate the shock-induced detonation process of NHOHN-, a representative salt of the pentazolate anion (N-). The well-trained NNP exhibits high precision comparable to DFT, as well as high efficiency. The NNP-based large-scale molecular dynamics (MD) simulations for NHOHN- produced an ideal C-J detonation velocity of 9.4 km/s, which is in agreement with the value estimated by the Cheetah 7.0 program (9.93 km/s). The simulation demonstrates that the proton transfer from NHOH to N- is the initial reaction, while the primary decomposition pathway of N- is a ring-opening reaction, or the bimolecular reactions with its initial decomposition intermediate azide anion N- resulting in the formation of N ring. Quantum chemical calculations show that these pathways possess low activation barriers. The influence of nuclear quantum effects on shock-induced chemical reactions was also studied, which shows that nuclear quantum corrections not only improve the accuracy of predicted ideal detonation velocity but also improve temperature in simulations, which results in the different reaction mechanism of shock-induced detonation reaction of NHOHN-, facilitating the ring-opening reaction of N- ring and preventing its reaction with N. This study enhances the understanding of the detonation mechanism of cyclo-pentazolate salts. - Source: PubMed
Publication date: 2026/05/07
Zhao JikaiZhang JidongZhang Weijing - Platelet activation via G protein-coupled receptors (GPCRs) is central to arterial thrombosis. P2Y12 is a canonical Gi-coupled receptor mediating ADP-dependent platelet activation, yet the role of Regulator of G protein Signaling 6 (RGS6), a modulator of Gi signaling, in platelet function and thrombosis remains unclear. - Source: PubMed
Publication date: 2026/04/30
Roytenberg RenatRorabaugh Boyd RYue HongJividen RobbieCameron Scott JLi Wei - Stent thrombosis (ST) is a severe complication of percutaneous coronary intervention (PCI), often presenting as acute myocardial infarction or sudden death. We present a case of a 51-year-old male patient with a history of hypertension and dyslipidemia who underwent elective PCI with stent implantation in the first marginal branch for the management of exertional angina. Five days post-procedure, he presented with an inferior ST-segment elevation myocardial infarction (STEMI). Urgent coronary angiography demonstrated subacute thrombosis of the circumflex artery and the ostium of the first marginal at the stent site. Platelet function testing using the vasodilator-stimulated phosphoprotein (VASP) index demonstrated high on-treatment platelet reactivity (HPR) to clopidogrel, which guided the decision to switch antiplatelet therapy to ticagrelor. The patient was successfully treated with glycoprotein IIb/IIIa inhibitors and with a switch from clopidogrel to ticagrelor as the P2Y12 receptor inhibitor. Follow-up angiography after 48 hours of glycoprotein IIb/IIIa inhibitor infusion showed complete thrombus resolution with restoration of normal blood flow. This case illustrates that a VASP index exceeding the 60% poor-response threshold may contribute to early ST, and that prompt platelet function testing should guide escalation to more potent P2Y12 receptor inhibitors in patients presenting with unexplained subacute ST. - Source: PubMed
Publication date: 2026/03/29
Nabhan EliasAndriamihary OberlinNaoum Nehme EdouardVana Alexandrina-PaulaPoulos Nabil - Acute coronary syndrome (ACS) remains a leading cause of global morbidity and mortality, often managed with antiplatelet therapy. However, variability in patient response due to comorbidities, genetic polymorphisms, and resistance to antiplatelet agents creates challenges in optimizing treatment. - Source: PubMed
Publication date: 2026/04/20
Venissa Rebello JeenalShah AshnaKarattuthodi Mohammed SalimMai Chun-WaiElnaem Mohamed Hassan